HitPredict

Interactor 1: HSP82 (P02829)
ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform)
Gene: HSP82

Interactor 2: TCPD (P39078)
T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta)
Gene: CCT4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	15879519, 31399574
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0006457 - protein folding GO:0016887 - ATP hydrolysis activity GO:0051082 - unfolded protein binding GO:0140662 - ATP-dependent protein folding chaperone
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 709 Sc			1 528
+	Hs
		437875 HS90B_HUMAN (5-709): 0: 1026: 62.13		TCPA_HUMAN (8-525): 0: 587: 30.97
+	Hs
		431514 HS90A_HUMAN (4-709): 0: 1015: 60.83		TCPA_HUMAN (8-525): 0: 587: 30.97
+	Hs
		437987 HS90B_HUMAN (5-709): 0: 1026: 62.13		TCPG_HUMAN (2-525): 0: 562: 29.68
+	Sc
		366298 HSP82_YEAST (1-709): 0: 984: 100.00		TCPG_YEAST (1-525): 0: 549: 27.05
+	Sc
		543748 HSC82_YEAST (1-709): 0: 973: 94.64		TCPG_YEAST (1-525): 0: 549: 27.05
+	Ca
		804497 HSP90_CANAL (4-709): 0: 959: 81.75		Q59YH4_CANAL (2-527): 0: 562: 29.16
+	Ca
		804551 HSP90_CANAL (4-709): 0: 959: 81.75		Q5AK16_CANAL (1-525): 0: 561: 29.30
+	Sc
		543749 HSC82_YEAST (1-709): 0: 973: 94.64		TCPD_YEAST (1-528): 0: 544: 100.00
+	Sc
		543936 HSC82_YEAST (1-709): 0: 973: 94.64		TCPH_YEAST (2-528): 0: 538: 28.20
+	Ca
		804500 HSP90_CANAL (4-709): 0: 959: 81.75		Q59Z12_CANAL (1-527): 0: 535: 35.09
+	Sc
		366392 HSP82_YEAST (1-709): 0: 984: 100.00		TCPE_YEAST (12-527): 1.47e-98: 310: 35.55
+	Sc
		543861 HSC82_YEAST (1-709): 0: 973: 94.64		TCPE_YEAST (12-527): 1.47e-98: 310: 35.55