Protein: KLK3
Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)

Gene: KLK3
Organism: Homo sapiens
Interactions: 55
UniProt ID: P07288

Gene Ontology (top 5):
GO:0002803 - positive regulation of antibacterial peptide production
GO:0003073 - regulation of systemic arterial blood pressure
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

425160

IPSP
Plasma serine protease inhibitor

2

18

Small-scale

0.811

High

455629

ANDR
Androgen receptor

7

9

Small-scale

0.738

High

287512

LRP6
Low-density lipoprotein receptor-related protein 6

1

15

High-throughput

0.691

High

455634

PRTN3
Myeloblastin

1

15

High-throughput

0.691

High

274851

LRP5
Low-density lipoprotein receptor-related protein 5

1

15

High-throughput

0.618

High

369297

A1AT
Alpha-1-antitrypsin

1

19

Small-scale

0.618

High

369585

A2MG
Alpha-2-macroglobulin

1

10

Small-scale

0.618

High

455635

ZA2G
Zinc-alpha-2-glycoprotein

1

6

High-throughput

0.618

High

72404

MI4GD
MIF4G domain-containing protein

3

2

High-throughput

0.609

High

455641

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

3

High-throughput

0.601

High

379192

IGHG1
Immunoglobulin heavy constant gamma 1

1

9

High-throughput

0.575

High

455630

BIP
Endoplasmic reticulum chaperone BiP

2

11

High-throughput

0.571

High

168175

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.536

High

326994

NXPH2
Neurexophilin-2

1

2

High-throughput

0.536

High

389928

ALBU
Albumin

1

7

High-throughput

0.536

High

455633

FGFR3
Fibroblast growth factor receptor 3

1

11

High-throughput

0.536

High

455637

GRN
Progranulin

1

1

High-throughput

0.536

High

455640

ANAG
Alpha-N-acetylglucosaminidase

1

2

High-throughput

0.536

High

455649

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

6

High-throughput

0.536

High

455655

VWDE
von Willebrand factor D and EGF domain-containing protein

1

12

High-throughput

0.536

High

455656

CHSTE
Carbohydrate sulfotransferase 14

1

3

High-throughput

0.536

High

455659

I17RA
Interleukin-17 receptor A

1

4

High-throughput

0.536

High

455661

DIDO1
Death-inducer obliterator 1

1

2

High-throughput

0.536

High

455663

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

455668

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

20

High-throughput

0.536

High

455669

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

18

High-throughput

0.536

High

214113

DHH
Desert hedgehog protein

1

0

High-throughput

0.513

High

455652

ZN550
Zinc finger protein 550

1

0

High-throughput

0.513

High

455666

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

455639

PLXA3
Plexin-A3

1

17

High-throughput

0.489

High

455644

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

9

High-throughput

0.489

High

455647

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

2

High-throughput

0.489

High

455653

FRAS1
Extracellular matrix organizing protein FRAS1

1

20

High-throughput

0.489

High

455662

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

9

High-throughput

0.489

High

455665

SEM6B
Semaphorin-6B

1

10

High-throughput

0.489

High

455667

SEM4G
Semaphorin-4G

1

12

High-throughput

0.489

High

407826

SEMG1
Semenogelin-1

1

2

High-throughput

0.479

High

455631

PPAP
Prostatic acid phosphatase

1

3

High-throughput

0.479

High

455632

H15
Histone H1.5

1

4

Small-scale

0.479

High

455642

SEMG2
Semenogelin-2

1

2

High-throughput

0.479

High

455643

REL
Proto-oncogene c-Rel

1

3

Small-scale

0.479

High

455648

DCAF6
DDB1- and CUL4-associated factor 6

1

3

High-throughput

0.479

High

455651

MYSM1
Deubiquitinase MYSM1

1

3

Small-scale

0.479

High

455657

KAT2B
Histone acetyltransferase KAT2B

1

2

Small-scale

0.479

High

455628

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.458

High

455638

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

455645

H31T
Histone H3.1t

1

0

Small-scale

0.458

High

455646

H2A2C
Histone H2A type 2-C

1

0

Small-scale

0.458

High

455660

ERP44
Endoplasmic reticulum resident protein 44

1

8

High-throughput

0.445

High

455658

SEH1
Nucleoporin SEH1

1

3

High-throughput

0.437

High

455670

GRIP1
Glutamate receptor-interacting protein 1

1

1

Small-scale

0.437

High

455636

DCK
Deoxycytidine kinase

1

0

High-throughput

0.279

Low

455650

TMM69
Transmembrane protein 69

1

0

High-throughput

0.279

Low

455654

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.279

Low

455664

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025