Interactor 1: PBPB (P02919)
Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.99.28) (Peptidoglycan TGase) (Peptidoglycan glycosyltransferase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)]
Gene: mrcB

Interactor 2: FTSI (P0AD68)
Peptidoglycan D,D-transpeptidase FtsI (EC 3.4.16.4) (Essential cell division protein FtsI) (Murein transpeptidase) (Penicillin-binding protein 3) (PBP-3) (Peptidoglycan synthase FtsI)
Gene: FTSI

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.812

The method score is based on:

Property Details
Experiments 19458048, 17938168, 18165305
Identification Methods pull down, adenylate cyclase complementation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Transgly~Transpeptidase, PBP_dimer~Transpeptidase, Transpeptidase~Transpeptidase
Common GO terms GO:0005886 - plasma membrane
GO:0006508 - proteolysis
GO:0008360 - regulation of cell shape
GO:0008658 - penicillin binding
GO:0008955 - peptidoglycan glycosyltransferase activity
and 2 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 844
Ec

1 588
+ Ec
+ Ec
+ Ss
+ Ss
+ Ec
+ Ss
+ Ss
+ Bs
+ Ss
+ Aa
+ Sp
+ Sa
+ Sa
+ Sa
+ Sa
+ Ec

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Last updated: 15 Jul 2024