Protein: IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH)

Gene: IDH2
Organism: Saccharomyces cerevisiae S288C
Interactions: 154
UniProt ID: P28241

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004449 - isocitrate dehydrogenase (NAD+) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

701494

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

14

17

Small-scale

0.981

High

701536

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

17

High-throughput

0.691

High

510265

HSP77
Import motor subunit, mitochondrial

3

8

High-throughput

0.640

High

642124

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

4

High-throughput

0.618

High

701513

LONM
Lon protease homolog, mitochondrial

2

10

High-throughput

0.588

High

578971

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.584

High

680567

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

2

1

High-throughput

0.584

High

701512

MIC60
MICOS complex subunit MIC60

2

2

High-throughput

0.584

High

701505

HSP78
Heat shock protein 78, mitochondrial

2

4

High-throughput

0.571

High

399803

COX4
Cytochrome c oxidase subunit 4, mitochondrial

2

0

High-throughput

0.559

High

701575

RUVB2
RuvB-like protein 2

2

2

High-throughput

0.558

High

526089

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

394308

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.536

High

453457

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.536

High

701508

GCN1
eIF-2-alpha kinase activator GCN1

1

4

High-throughput

0.536

High

701520

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.536

High

701556

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

3

High-throughput

0.536

High

701558

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

701572

NEW1
[NU+] prion formation protein 1

1

3

High-throughput

0.536

High

392348

HSP82
ATP-dependent molecular chaperone HSP82

2

7

High-throughput

0.521

High

364959

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.513

High

386603

TBB
Tubulin beta chain

1

3

High-throughput

0.489

High

486066

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.489

High

523252

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.489

High

701496

DBF20
Serine/threonine-protein kinase DBF20

1

3

High-throughput

0.489

High

701504

PRS6B
26S proteasome regulatory subunit 6B homolog

1

6

High-throughput

0.489

High

701509

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.489

High

701528

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.489

High

701532

IMB4
Importin subunit beta-4

1

3

High-throughput

0.489

High

701544

RSSA2
Small ribosomal subunit protein uS2B

1

5

High-throughput

0.489

High

366960

ATPB
ATP synthase subunit beta, mitochondrial

1

9

High-throughput

0.479

High

368141

THDH
Threonine dehydratase, mitochondrial

1

3

High-throughput

0.479

High

409977

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

433497

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

434889

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

452637

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

1

High-throughput

0.479

High

452842

ATPA
ATP synthase subunit alpha, mitochondrial

1

9

High-throughput

0.479

High

454636

PUT2
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

454923

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

456354

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.479

High

514501

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

518227

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.479

High

594896

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

604916

MDHM
Malate dehydrogenase, mitochondrial

1

8

High-throughput

0.479

High

622330

ACON
Aconitate hydratase, mitochondrial

1

5

High-throughput

0.479

High

626628

HSP60
Heat shock protein 60, mitochondrial

1

5

High-throughput

0.479

High

635939

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

5

High-throughput

0.479

High

654586

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.479

High

673475

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

3

High-throughput

0.479

High

679445

CDC48
Cell division control protein 48

1

6

High-throughput

0.479

High

682185

SPB4
ATP-dependent rRNA helicase SPB4

1

4

High-throughput

0.479

High

685097

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

1

High-throughput

0.479

High

694461

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

701493

HIBCH
Small ribosomal subunit protein mS47

1

2

High-throughput

0.479

High

701501

PREP
Presequence protease, mitochondrial

1

4

High-throughput

0.479

High

701503

YPT7
Ypt/Rab-type GTPase YPT7

1

2

Small-scale

0.479

High

701510

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.479

High

701511

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

701522

TOM71
Protein TOM71

1

4

High-throughput

0.479

High

701529

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

701531

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

3

High-throughput

0.479

High

701534

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

1

High-throughput

0.479

High

701541

ETFB
Probable electron transfer flavoprotein subunit beta

1

2

High-throughput

0.479

High

701543

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

701549

ALAT1
Alanine aminotransferase, mitochondrial

1

4

High-throughput

0.479

High

701551

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

701552

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

701555

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

701559

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

1

High-throughput

0.479

High

701560

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

701561

ABF2
ARS-binding factor 2, mitochondrial

1

4

Small-scale

0.479

High

701562

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

1

High-throughput

0.479

High

701563

RT10
Small ribosomal subunit protein uS10m

1

3

High-throughput

0.479

High

701566

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.479

High

701571

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

701573

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

701574

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.479

High

701576

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

439103

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

677787

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

678776

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

697317

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.458

High

701500

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

701517

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.458

High

701523

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

701526

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

701537

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

701538

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

701542

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

517930

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.457

High

701540

BNI1
Protein BNI1

1

2

High-throughput

0.457

High

602346

PHO85
Cyclin-dependent protein kinase PHO85

1

5

High-throughput

0.457

High

624973

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.457

High

675275

DMC1
Meiotic recombination protein DMC1

1

1

High-throughput

0.457

High

701525

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.457

High

701530

HAT2
Histone acetyltransferase type B subunit 2

1

8

High-throughput

0.457

High

701539

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.457

High

701550

RPN14
26S proteasome regulatory subunit RPN14

1

8

High-throughput

0.457

High

701565

UTP5
U3 small nucleolar RNA-associated protein 5

1

3

High-throughput

0.457

High

577049

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.445

High

149631

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

364382

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.437

High

383565

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

435823

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

441752

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

454614

PROF
Profilin

1

1

High-throughput

0.437

High

502895

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504079

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

512304

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

512867

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

558615

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

670412

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

674462

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.437

High

689309

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

701495

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

701497

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.437

High

701499

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.437

High

701502

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.437

High

701507

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

701514

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.437

High

701519

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

701527

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

701546

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.437

High

701547

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

701548

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

701553

COPA
Coatomer subunit alpha

1

6

High-throughput

0.437

High

701557

H3
Histone H3

1

1

High-throughput

0.437

High

701564

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

701567

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

701570

MCA1
Metacaspase-1

1

1

High-throughput

0.437

High

399348

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

5

High-throughput

0.407

High

544046

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.407

High

592063

VATB
V-type proton ATPase subunit B

1

9

High-throughput

0.407

High

701506

IXR1
Intrastrand cross-link recognition protein

1

3

High-throughput

0.407

High

701533

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

2

High-throughput

0.407

High

701535

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.407

High

701545

NMD5
Nonsense-mediated mRNA decay protein 5

1

4

High-throughput

0.407

High

535986

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

2

0

High-throughput

0.324

High

471381

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

0

High-throughput

0.313

High

449320

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

High-throughput

0.279

Low

459042

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

661205

SPO13
Meiosis-specific protein SPO13

1

0

High-throughput

0.279

Low

701518

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.279

Low

576944

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.265

Low

672220

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

701498

ARP2
Actin-related protein 2

1

0

High-throughput

0.261

Low

701569

SHS1
Seventh homolog of septin 1

1

0

High-throughput

0.261

Low

676610

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

701515

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.249

Low

701516

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

701521

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

701524

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

701554

NSG2
Protein NSG2

1

0

High-throughput

0.249

Low

701568

NCS1
Calcium-binding protein NCS-1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025