Protein: LYS12
Homoisocitrate dehydrogenase, mitochondrial (HIcDH) (EC 1.1.1.87)

Gene: LYS12
Organism: Saccharomyces cerevisiae S288C
Interactions: 171
UniProt ID: P40495

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0005739 - mitochondrion
GO:0009085 - lysine biosynthetic process
GO:0019878 - lysine biosynthetic process via aminoadipic acid
GO:0047046 - homoisocitrate dehydrogenase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

701536

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

17

High-throughput

0.691

High

825466

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

2

3

High-throughput

0.611

High

579528

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.584

High

727088

HS104
Heat shock protein 104

3

4

Small-scale

0.578

High

368170

THDH
Threonine dehydratase, mitochondrial

2

3

High-throughput

0.571

High

644792

CLH
Clathrin heavy chain

2

1

High-throughput

0.567

High

825449

COPB2
Coatomer subunit beta'

2

8

High-throughput

0.565

High

825467

ERG13
Hydroxymethylglutaryl-CoA synthase

2

0

High-throughput

0.563

High

825495

JID1
J domain-containing protein 1

2

0

High-throughput

0.563

High

818943

SSB2
Ribosome-associated molecular chaperone SSB2

3

6

High-throughput

0.558

High

392852

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.558

High

825496

AHA1
Hsp90 co-chaperone AHA1

2

1

High-throughput

0.558

High

814208

RV167
Reduced viability upon starvation protein 167

2

3

High-throughput

0.549

High

734685

IMB3
Importin subunit beta-3

2

6

High-throughput

0.537

High

825451

EMW1
Essential for maintenance of the cell wall protein 1

2

2

High-throughput

0.537

High

825468

CTR9
RNA polymerase-associated protein CTR9

2

1

High-throughput

0.537

High

453635

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.536

High

750192

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.536

High

755113

GCN1
eIF-2-alpha kinase activator GCN1

1

4

High-throughput

0.536

High

825446

MAM33
Mitochondrial acidic protein MAM33

1

1

High-throughput

0.536

High

825469

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

6

High-throughput

0.536

High

825457

YPT11
GTP-binding protein YPT11

1

1

High-throughput

0.515

High

825485

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.513

High

804216

SSZ1
Ribosome-associated complex subunit SSZ1

2

1

High-throughput

0.504

High

781878

CAF4
CCR4-associated factor 4

1

8

High-throughput

0.500

High

386737

TBB
Tubulin beta chain

1

3

High-throughput

0.489

High

440852

KIN28
Serine/threonine-protein kinase KIN28

1

6

High-throughput

0.489

High

486209

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.489

High

575464

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.489

High

645743

HSP74
Heat shock protein SSA4

1

6

High-throughput

0.489

High

688904

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.489

High

722006

XPO1
Exportin-1

1

2

High-throughput

0.489

High

734119

EF2
Elongation factor 2

1

1

High-throughput

0.489

High

738063

MKK2
MAP kinase kinase MKK2/SSP33

1

4

High-throughput

0.489

High

751188

CSE1
Importin alpha re-exporter

1

5

High-throughput

0.489

High

802557

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.489

High

802636

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.489

High

817876

IMB4
Importin subunit beta-4

1

3

High-throughput

0.489

High

825452

RSSA2
Small ribosomal subunit protein uS2B

1

5

High-throughput

0.489

High

825464

COPA
Coatomer subunit alpha

1

8

High-throughput

0.489

High

825474

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.489

High

825476

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.489

High

825478

KU80
ATP-dependent DNA helicase II subunit 2

1

3

High-throughput

0.489

High

439355

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.479

High

510553

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.479

High

514670

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

647133

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

679769

CDC48
Cell division control protein 48

1

6

High-throughput

0.479

High

752345

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.479

High

781395

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.479

High

815138

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

825475

GIS1
Transcriptional activator/repressor GIS1

1

2

High-throughput

0.479

High

825480

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.479

High

825492

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

825494

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

825471

OSH6
Oxysterol-binding protein homolog 6

1

1

High-throughput

0.470

High

779486

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

801780

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.458

High

808789

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.458

High

518049

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.457

High

453960

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.457

High

602499

PHO85
Cyclin-dependent protein kinase PHO85

1

6

High-throughput

0.457

High

633477

PP11
Serine/threonine-protein phosphatase PP1-1

1

3

High-throughput

0.457

High

796086

IMB2
Importin subunit beta-2

1

5

High-throughput

0.457

High

809078

DUN1
DNA damage response protein kinase DUN1

1

3

High-throughput

0.457

High

825460

RPN14
26S proteasome regulatory subunit RPN14

1

11

High-throughput

0.457

High

394629

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

470539

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.445

High

526878

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

554934

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.445

High

736854

APE2
Aminopeptidase 2, mitochondrial

1

1

High-throughput

0.445

High

753002

XPOT
Exportin-T

1

3

High-throughput

0.445

High

825453

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

825491

HOSM
Homocitrate synthase, mitochondrial

1

2

High-throughput

0.445

High

149803

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

364580

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.437

High

383736

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

410173

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433681

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

435140

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.437

High

436004

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

441950

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

455103

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

503084

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504251

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

512479

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

513047

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

518312

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.437

High

558757

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

646430

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.437

High

670802

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

674666

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.437

High

682304

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.437

High

689498

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

707303

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

747408

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.437

High

753411

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

762385

PEX5
Peroxisomal targeting signal receptor

1

2

High-throughput

0.437

High

763910

SPT10
Protein SPT10

1

1

High-throughput

0.437

High

764091

SPT21
Protein SPT21

1

1

High-throughput

0.437

High

778366

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

792085

GBLP
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.437

High

802210

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

803135

ECM29
Proteasome component ECM29

1

3

High-throughput

0.437

High

825456

HLJ1
Protein HLJ1

1

1

High-throughput

0.437

High

825458

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

825462

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

825470

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

825481

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

825484

SUB2
ATP-dependent RNA helicase SUB2

1

3

High-throughput

0.437

High

825487

MCA1
Metacaspase-1

1

1

High-throughput

0.437

High

825488

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

825493

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

416819

DNLI1
DNA ligase 1

1

0

High-throughput

0.426

High

417116

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.426

High

450599

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

694563

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

746581

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

0

High-throughput

0.426

High

822004

PSA4
Proteasome subunit alpha type-4

1

0

High-throughput

0.426

High

427310

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

486471

TBA3
Tubulin alpha-3 chain

1

4

High-throughput

0.407

High

524175

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.407

High

585956

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.407

High

592295

VATB
V-type proton ATPase subunit B

1

8

High-throughput

0.407

High

628264

ZRC1
Vacuolar zinc transporter ZRC1

1

1

High-throughput

0.407

High

672107

PUF4
Pumilio homology domain family member 4

1

1

High-throughput

0.407

High

708748

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.407

High

737290

HXT4
Low-affinity glucose transporter HXT4

1

2

High-throughput

0.407

High

752970

IXR1
Intrastrand cross-link recognition protein

1

3

High-throughput

0.407

High

801750

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.407

High

803575

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.407

High

807230

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.407

High

825031

MET18
DNA repair/transcription protein MET18/MMS19

1

2

High-throughput

0.407

High

825454

NMD5
Nonsense-mediated mRNA decay protein 5

1

4

High-throughput

0.407

High

825455

MET5
Sulfite reductase [NADPH] subunit beta

1

1

High-throughput

0.407

High

825463

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.407

High

825465

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.407

High

825477

SXM1
Importin beta SMX1

1

4

High-throughput

0.407

High

825489

AP1G1
AP-1 complex subunit gamma-1

1

1

High-throughput

0.407

High

825497

SKS1
Serine/threonine-protein kinase SKS1

1

3

High-throughput

0.407

High

701707

URA7
CTP synthase 1

3

0

High-throughput

0.335

High

825486

CDC45
Cell division control protein 45

2

0

High-throughput

0.313

High

670280

NAP1
Nucleosome assembly protein

2

0

High-throughput

0.307

High

805299

GGA2
ADP-ribosylation factor-binding protein GGA2

2

0

High-throughput

0.307

High

825447

LCB2
Serine palmitoyltransferase 2

2

0

High-throughput

0.307

High

796746

RXT2
Transcriptional regulatory protein RXT2

1

0

High-throughput

0.279

Low

813553

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.279

Low

825448

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.279

Low

825450

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.279

Low

805875

YHT8
Uncharacterized protein YHR138C

1

0

High-throughput

0.269

Low

825461

ART5
Arrestin-related trafficking adapter 5

1

0

High-throughput

0.269

Low

531339

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.249

Low

795032

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

798687

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

825482

VTA1
Vacuolar protein sorting-associated protein VTA1

1

0

High-throughput

0.249

Low

825483

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

825490

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

382147

H4
Histone H4

1

0

High-throughput

0.232

Low

484304

KEX1
Pheromone-processing carboxypeptidase KEX1

1

0

High-throughput

0.232

Low

676062

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low

703823

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.232

Low

740268

SMI1
Cell wall assembly regulator SMI1

1

0

High-throughput

0.232

Low

744500

KA122
Importin beta-like protein KAP122

1

0

High-throughput

0.232

Low

751230

DOM34
Protein DOM34

1

0

High-throughput

0.232

Low

812231

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

818378

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

0

High-throughput

0.232

Low

825459

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.232

Low

825472

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

High-throughput

0.232

Low

825473

VPS16
Vacuolar protein sorting-associated protein 16

1

0

High-throughput

0.232

Low

825479

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.232

Low

825498

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025