HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: GELS (P06396)
Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)
Gene: GSN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	20308691, 21182205, 25604459
Identification Methods	affinity chromatography technology, cosedimentation through density gradient, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 782
+	Hs
		414017 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Hs
		93996 F1D8P7_HUMAN (103-548): 1.37e-102: 320: 21.43		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Hs
		1270065 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SCIN_HUMAN (51-768): 0: 1007: 59.72
+	Hs
		413810 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		GELS_HUMAN (1-782): 0: 1207: 100.00
+	Hs
		369509 ESR1_HUMAN (1-595): 0: 599: 100.00		FLII_HUMAN (373-765): 2.36e-57: 214: 22.88
+	Hs
		313719 ESR1_HUMAN (1-595): 0: 599: 100.00		SVIL_HUMAN (551-779): 2.11e-24: 112: 21.86
+	Hs
		1023211 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		FLII_HUMAN (373-765): 2.36e-57: 214: 22.88
+	Hs
		377027 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		VILI_HUMAN (68-467): 1.52e-69: 246: 28.22
+	Hs
		313722 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		SVIL_HUMAN (551-779): 2.11e-24: 112: 21.86
+	Hs
		313768 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		SVIL_HUMAN (551-779): 2.11e-24: 112: 21.86
+	Hs
		487386 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		FLII_HUMAN (373-765): 2.36e-57: 214: 22.88
+	Hs
		313734 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		SVIL_HUMAN (551-779): 2.11e-24: 112: 21.86