Protein: PDCD6
Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)

Gene: PDCD6
Organism: Homo sapiens
Interactions: 155
UniProt ID: O75340

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001525 - angiogenesis
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0005509 - calcium ion binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

259800

PEF1
Peflin

11

16

Small-scale

0.982

High

259807

HEBP2
Heme-binding protein 2

6

0

Small-scale

0.907

High

259666

PDCD6
Programmed cell death protein 6

4

16

Small-scale

0.899

High

259760

PDC6I
Programmed cell death 6-interacting protein

8

13

Small-scale

0.757

High

259715

DAPK1
Death-associated protein kinase 1

1

18

Small-scale

0.740

High

259669

SC31A
Protein transport protein Sec31A

6

4

Small-scale

0.740

High

259679

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

5

High-throughput

0.737

High

259776

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

9

Small-scale

0.724

High

259713

ANX11
Annexin A11

5

4

Small-scale

0.721

High

64573

MYH7B
Myosin-7B

1

6

High-throughput

0.691

High

259686

MYH7
Myosin-7

1

6

High-throughput

0.691

High

259742

KLH12
Kelch-like protein 12

3

3

Small-scale

0.678

High

60540

VP37C
Vacuolar protein sorting-associated protein 37C

3

3

High-throughput

0.675

High

259731

CUL3
Cullin-3

3

7

Small-scale

0.664

High

259687

CFTR
Cystic fibrosis transmembrane conductance regulator

3

6

High-throughput

0.643

High

259718

SEC13
Protein SEC13 homolog

2

1

Small-scale

0.639

High

148202

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.618

High

160285

AURKA
Aurora kinase A

1

7

High-throughput

0.618

High

259689

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

Small-scale

0.618

High

259695

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

5

Small-scale

0.618

High

259720

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.618

High

259675

MYC
Myc proto-oncogene protein

2

9

High-throughput

0.611

High

259808

S23IP
SEC23-interacting protein

2

4

Small-scale

0.611

High

259671

BAG4
BAG family molecular chaperone regulator 4

2

4

High-throughput

0.606

High

259795

PLS3
Phospholipid scramblase 3

1

1

Small-scale

0.601

High

259694

VCAM1
Vascular cell adhesion protein 1

2

5

High-throughput

0.601

High

259684

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

Small-scale

0.595

High

259698

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

Small-scale

0.586

High

259682

P53
Cellular tumor antigen p53

2

4

Small-scale

0.584

High

259777

TS101
Tumor susceptibility gene 101 protein

2

1

Small-scale

0.584

High

63512

PRR19
Proline-rich protein 19

2

0

High-throughput

0.580

High

259769

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

Small-scale

0.578

High

259678

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

177152

HDAC3
Histone deacetylase 3

1

1

High-throughput

0.536

High

259691

CCNB1
G2/mitotic-specific cyclin-B1

1

1

High-throughput

0.536

High

259693

H2AX
Histone H2AX

1

2

High-throughput

0.536

High

259697

CCNA2
Cyclin-A2

1

1

High-throughput

0.536

High

259701

GRN
Progranulin

1

1

High-throughput

0.536

High

259708

MAGA1
Melanoma-associated antigen 1

1

4

High-throughput

0.536

High

259709

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.536

High

259716

IST1
IST1 homolog

1

3

High-throughput

0.536

High

259729

CUL1
Cullin-1

1

7

High-throughput

0.536

High

259730

CUL2
Cullin-2

1

7

High-throughput

0.536

High

259732

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.536

High

259746

SAMD1
Sterile alpha motif domain-containing protein 1

1

4

High-throughput

0.536

High

259750

URP2
Fermitin family homolog 3

1

2

High-throughput

0.536

High

259766

CUL5
Cullin-5

1

7

High-throughput

0.536

High

259791

TF7L2
Transcription factor 7-like 2

1

4

High-throughput

0.536

High

259705

VGFR2
Vascular endothelial growth factor receptor 2

1

2

Small-scale

0.529

High

259747

RHG36
Rho GTPase-activating protein 36

2

8

High-throughput

0.521

High

259707

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

5

Small-scale

0.516

High

259706

CCNF
Cyclin-F

1

6

High-throughput

0.515

High

259743

Q5T0G8
Annexin

1

4

High-throughput

0.515

High

259751

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

259761

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.513

High

259775

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

259789

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

259790

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

259805

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

259784

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

6

Small-scale

0.506

High

259699

1433T
14-3-3 protein theta

1

7

High-throughput

0.501

High

259768

SH3K1
SH3 domain-containing kinase-binding protein 1

1

2

Small-scale

0.501

High

259796

DIAP3
Protein diaphanous homolog 3

1

6

Small-scale

0.501

High

259803

FND3A
Fibronectin type-III domain-containing protein 3A

1

7

Small-scale

0.501

High

259755

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

3

High-throughput

0.494

High

259728

DCTN2
Dynactin subunit 2

1

0

Small-scale

0.493

High

259724

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.489

High

125042

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

7

High-throughput

0.479

High

146122

ARI1A
AT-rich interactive domain-containing protein 1A

1

5

Small-scale

0.479

High

162263

XPO1
Exportin-1

1

2

High-throughput

0.479

High

164718

SC16A
Protein transport protein Sec16A

1

4

Small-scale

0.479

High

177748

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

259667

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.479

High

259668

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

259670

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

259672

SC24B
Protein transport protein Sec24B

1

3

Small-scale

0.479

High

259674

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

259676

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

259677

FINC
Fibronectin

1

5

High-throughput

0.479

High

259680

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

259681

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

259683

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

259688

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

259692

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

259696

ANXA7
Annexin A7

1

5

Small-scale

0.479

High

259700

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

259702

MERL
Merlin

1

5

High-throughput

0.479

High

259703

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

259704

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.479

High

259712

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

259717

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

259721

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

259723

1433Z
14-3-3 protein zeta/delta

1

7

High-throughput

0.479

High

259725

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

259727

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

259734

CUL7
Cullin-7

1

4

High-throughput

0.479

High

259736

TNIP1
TNFAIP3-interacting protein 1

1

8

Small-scale

0.479

High

259737

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

259738

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

259739

SC23A
Protein transport protein Sec23A

1

3

Small-scale

0.479

High

259741

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

259748

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

259749

KI21A
Kinesin-like protein KIF21A

1

4

High-throughput

0.479

High

259753

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

3

Small-scale

0.479

High

259756

ARI1B
AT-rich interactive domain-containing protein 1B

1

3

Small-scale

0.479

High

259757

TNIP2
TNFAIP3-interacting protein 2

1

3

High-throughput

0.479

High

259758

SMRC2
SWI/SNF complex subunit SMARCC2

1

5

Small-scale

0.479

High

259759

RHBL4
Rhomboid-related protein 4

1

5

Small-scale

0.479

High

259762

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

259763

TFG
Protein TFG

1

4

Small-scale

0.479

High

259764

REQU
Zinc finger protein ubi-d4

1

5

Small-scale

0.479

High

259765

SMRC1
SWI/SNF complex subunit SMARCC1

1

4

Small-scale

0.479

High

259767

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

4

Small-scale

0.479

High

259770

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

259774

KCD15
BTB/POZ domain-containing protein KCTD15

1

4

Small-scale

0.479

High

259778

OVOL2
Transcription factor Ovo-like 2

1

1

Small-scale

0.479

High

259780

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

259782

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

259785

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

259787

DUS21
Dual specificity protein phosphatase 21

1

5

High-throughput

0.479

High

259788

ECT2
Protein ECT2

1

7

High-throughput

0.479

High

259792

ANLN
Anillin

1

4

High-throughput

0.479

High

259793

PLS4
Phospholipid scramblase 4

1

1

Small-scale

0.479

High

259794

RNC
Ribonuclease 3

1

4

High-throughput

0.479

High

259797

HAUS2
HAUS augmin-like complex subunit 2

1

1

High-throughput

0.479

High

259798

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

259799

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.479

High

259801

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

259802

UBQL2
Ubiquilin-2

1

5

High-throughput

0.479

High

259806

ARI1
E3 ubiquitin-protein ligase ARIH1

1

10

High-throughput

0.479

High

259690

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

259710

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

259714

SMCA2
Probable global transcription activator SNF2L2

1

0

Small-scale

0.458

High

259726

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

259733

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

259735

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

259745

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

259754

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

259772

MB12A
Multivesicular body subunit 12A

1

0

Small-scale

0.458

High

259773

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

Small-scale

0.458

High

259673

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.445

High

259685

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

259719

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

7

High-throughput

0.445

High

259722

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.445

High

259781

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

7

High-throughput

0.445

High

259786

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

7

High-throughput

0.445

High

259744

RC3H1
Roquin-1

1

1

High-throughput

0.437

High

259804

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

259740

NEDD8
NEDD8

1

0

High-throughput

0.426

High

259711

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

259783

GCP60
Golgi resident protein GCP60

1

2

Small-scale

0.407

High

259771

SHSA4
Protein shisa-4

1

0

Small-scale

0.279

Low

259752

SL9A9
Sodium/hydrogen exchanger 9

1

0

Small-scale

0.249

Low

259779

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024