Protein: SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (Mitochondrial glutamyl-tRNA synthetase) (mtGluRS)

Gene: SYEM, EARS2
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q5JPH6

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004818 - glutamate-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

774400

BASI
Basigin

4

1

High-throughput

0.691

High

1205718

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.611

High

279781

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1162355

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1205728

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.554

High

1205756

NPTN
Neuroplastin

2

1

High-throughput

0.549

High

1205723

TRI43
Tripartite motif-containing protein 43

1

2

High-throughput

0.536

High

1205726

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

1205731

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

216710

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

690502

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

869172

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

1160386

TAZ
Tafazzin

1

0

High-throughput

0.513

High

1205713

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

1205715

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1205744

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

1205745

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

1205748

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1205753

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

133258

P2Y10
Putative P2Y purinoceptor 10

1

2

High-throughput

0.489

High

182565

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.489

High

406893

MAS
Proto-oncogene Mas

1

2

High-throughput

0.489

High

538613

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.489

High

638434

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.489

High

1205749

TSP50
Probable threonine protease PRSS50

1

2

High-throughput

0.489

High

1205752

GPR55
G-protein coupled receptor 55

1

4

High-throughput

0.489

High

241897

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

293802

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

342207

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.479

High

348538

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

High-throughput

0.479

High

350887

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

412050

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

639750

TAF1
Transcription initiation factor TFIID subunit 1

1

3

High-throughput

0.479

High

882706

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

1024059

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

1087407

GRSF1
G-rich sequence factor 1

1

1

High-throughput

0.479

High

1090422

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

1107797

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1205710

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1205717

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1205727

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

1205734

MTRFR
Mitochondrial translation release factor in rescue

1

1

High-throughput

0.479

High

1205738

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1205739

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

1205741

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

1205746

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

1205747

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

471062

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519127

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

559978

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

828795

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841771

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851908

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

1048542

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058057

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1117749

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1205722

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1205724

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1205730

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1205732

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1205742

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1205754

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

185756

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.457

High

1065

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.445

High

1205711

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1205751

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

106064

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

129152

MEN1
Menin

1

2

High-throughput

0.437

High

385818

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.437

High

768361

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

830864

CCNF
Cyclin-F

1

2

High-throughput

0.437

High

869603

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

1

Small-scale

0.437

High

942669

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.437

High

1106569

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.437

High

1113297

CUL3
Cullin-3

1

4

High-throughput

0.437

High

1161297

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

High-throughput

0.437

High

1205716

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1205725

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

1205735

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1205740

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.437

High

652199

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.407

High

669330

ACKR3
Atypical chemokine receptor 3

1

3

High-throughput

0.407

High

754036

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.407

High

886065

CXCR3
C-X-C chemokine receptor type 3

1

2

High-throughput

0.407

High

956894

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.407

High

1205712

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

1205733

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.407

High

220171

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

732993

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

749341

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

1034742

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

1205720

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1205729

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.279

Low

1205743

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1205755

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1006255

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.269

Low

1178173

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1205737

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

457486

TBB5
Tubulin beta chain

1

0

High-throughput

0.232

Low

1165217

F187B
Protein FAM187B

1

0

High-throughput

0.232

Low

1168607

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

0

High-throughput

0.232

Low

1205714

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1205719

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.232

Low

1205721

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

1205736

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.232

Low

1205750

PCDGG
Protocadherin gamma-B4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025