HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	26487511, 21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007200 - phospholipase C-activating G protein-coupled receptor signaling pathway and 1 others more... GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 340
+	Hs
		369344 ESR1_HUMAN (1-595): 0: 599: 100.00		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		370470 ESR1_HUMAN (1-595): 0: 599: 100.00		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		369932 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5B_HUMAN (71-340): 2.74e-83: 257: 25.18
+	Hs
		369305 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Hs
		921671 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		921023 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		560885 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		196938 ESR1_HUMAN (1-595): 0: 599: 100.00		PRP4_HUMAN (51-253): 1.06e-12: 70.5: 25.85
+	Hs
		320198 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		320197 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		320228 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		320167 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24
+	Hs
		377230 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		377229 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00
+	Hs
		1334929 NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		903403 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Hs
		782513 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Hs
		1269746 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NLE1_HUMAN (3-124): 6.68e-32: 126: 25.41
+	Mm
		903664 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		WDR5_MOUSE (4-211): 4.16e-56: 187: 20.93
+	Hs
		197064 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRP4_HUMAN (51-253): 1.06e-12: 70.5: 25.85