HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: CCDC6 (Q16204)
Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)
Gene: CCDC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 474
+	Hs
		370819 ESR1_HUMAN (1-595): 0: 599: 100.00		MRCKB_HUMAN (23-351): 2.44e-20: 96.6: 14.57
+	Hs
		369096 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH9_HUMAN (4-401): 5.49e-12: 70.4: 11.78
+	Hs
		370120 ESR1_HUMAN (1-595): 0: 599: 100.00		MY18A_HUMAN (62-328): 1.49e-10: 65.8: 15.87
+	Hs
		368902 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH6_HUMAN (20-389): 4.46e-10: 64.2: 9.00
+	Hs
		148263 ESR1_HUMAN (1-595): 0: 599: 100.00		CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78
+	Hs
		369641 ESR1_HUMAN (1-595): 0: 599: 100.00		PLEC_HUMAN (67-346): 2.74e-09: 61.9: 11.79
+	Hs
		1081115 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CCDC6_HUMAN (1-474): 2.18e-48: 174: 100.00
+	Hs
		1150622 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MRCKG_HUMAN (1-433): 4.02e-31: 129: 15.49
+	Hs
		1051388 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DCTN1_HUMAN (2-361): 1.64e-21: 100: 14.02
+	Hs
		1270038 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MRCKB_HUMAN (23-351): 2.44e-20: 96.6: 14.57
+	Hs
		724944 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH9_HUMAN (4-401): 5.49e-12: 70.4: 11.78
+	Hs
		1268061 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MY18A_HUMAN (62-328): 1.49e-10: 65.8: 15.87
+	Hs
		149132 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78
+	Hs
		1068618 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PLEC_HUMAN (67-346): 2.74e-09: 61.9: 11.79
+	Hs
		522631 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH7_HUMAN (3-404): 7.14e-09: 60.4: 10.67
+	Hs
		1269900 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH13_HUMAN (10-371): 9.92e-09: 60: 13.66
+	Hs
		1270044 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH4_HUMAN (37-301): 9.75e-09: 60: 13.70
+	Hs
		587127 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		MYH9_HUMAN (4-401): 5.49e-12: 70.4: 11.78
+	Hs
		659748 RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64		MRCKB_HUMAN (23-351): 2.44e-20: 96.6: 14.57
+	Hs
		377795 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		MYH2_HUMAN (27-306): 9.34e-09: 60: 9.97