Protein: FOXC1
Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3)

Gene: FOXC1
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q12948

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

221935

FOXS1
Forkhead box protein S1

1

19

High-throughput

0.691

High

1091091

FOXD4
Forkhead box protein D4

1

18

High-throughput

0.691

High

1091147

FOXC2
Forkhead box protein C2

1

18

High-throughput

0.691

High

1091166

FOXJ2
Forkhead box protein J2

1

19

High-throughput

0.691

High

1091116

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

3

15

High-throughput

0.675

High

473957

NFIC
Nuclear factor 1 C-type

3

20

High-throughput

0.656

High

872273

SOX2
Transcription factor SOX-2

3

20

Small-scale

0.656

High

1091103

NFIX
Nuclear factor 1 X-type

3

20

High-throughput

0.640

High

1091128

METL6
tRNA N(3)-cytidine methyltransferase METTL6

3

0

High-throughput

0.638

High

537067

HSP7C
Heat shock cognate 71 kDa protein

2

5

High-throughput

0.628

High

717786

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

14

High-throughput

0.628

High

991017

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

15

High-throughput

0.628

High

823836

PBX1
Pre-B-cell leukemia transcription factor 1

2

15

Small-scale

0.628

High

190060

FOXP2
Forkhead box protein P2

1

20

Small-scale

0.618

High

609926

SPI1
Transcription factor PU.1

1

12

High-throughput

0.618

High

738975

ELF1
ETS-related transcription factor Elf-1

1

14

High-throughput

0.618

High

832978

ETV6
Transcription factor ETV6

1

14

High-throughput

0.618

High

1091092

FOXI1
Forkhead box protein I1

1

18

High-throughput

0.618

High

1091093

FOXL1
Forkhead box protein L1

1

18

High-throughput

0.618

High

1091124

FOXP4
Forkhead box protein P4

1

18

Small-scale

0.618

High

1091142

FEV
Protein FEV

1

13

High-throughput

0.618

High

1091155

FOXP1
Forkhead box protein P1

1

19

Small-scale

0.618

High

243616

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

2

20

High-throughput

0.611

High

854835

RECQ1
ATP-dependent DNA helicase Q1

2

9

High-throughput

0.611

High

977474

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

8

High-throughput

0.611

High

1086201

TFCP2
Alpha-globin transcription factor CP2

2

9

Small-scale

0.611

High

1091132

P66B
Transcriptional repressor p66-beta

2

2

High-throughput

0.611

High

142973

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.584

High

697095

APEX1
DNA repair nuclease/redox regulator APEX1

2

1

High-throughput

0.584

High

980733

H2B1C
Histone H2B type 1-C/E/F/G/I

2

4

High-throughput

0.584

High

1087715

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1091090

FOXC1
Forkhead box protein C1

1

18

High-throughput

0.575

High

123086

DX39A
ATP-dependent RNA helicase DDX39A

1

12

High-throughput

0.536

High

137129

MEIS1
Homeobox protein Meis1

1

11

High-throughput

0.536

High

162826

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

6

High-throughput

0.536

High

166146

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

346989

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.536

High

413729

P53
Cellular tumor antigen p53

1

12

High-throughput

0.536

High

593096

CREB1
Cyclic AMP-responsive element-binding protein 1

1

5

High-throughput

0.536

High

604814

HXB9
Homeobox protein Hox-B9

1

20

High-throughput

0.536

High

687792

SYVC
Valine--tRNA ligase

1

18

High-throughput

0.536

High

703304

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

20

High-throughput

0.536

High

725180

HXC13
Homeobox protein Hox-C13

1

20

High-throughput

0.536

High

771588

HXD13
Homeobox protein Hox-D13

1

20

High-throughput

0.536

High

823882

PBX2
Pre-B-cell leukemia transcription factor 2

1

15

High-throughput

0.536

High

904658

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.536

High

930866

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.536

High

939886

DLX5
Homeobox protein DLX-5

1

20

High-throughput

0.536

High

1032747

SATB1
DNA-binding protein SATB1

1

20

High-throughput

0.536

High

1091106

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

6

High-throughput

0.536

High

1091117

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.536

High

1091119

BCOR
BCL-6 corepressor

1

11

Small-scale

0.536

High

1091122

LDB1
LIM domain-binding protein 1

1

4

High-throughput

0.536

High

1091146

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.536

High

1091158

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

1091162

SALL1
Sal-like protein 1

1

9

High-throughput

0.536

High

1091164

UBIP1
Upstream-binding protein 1

1

9

High-throughput

0.536

High

1091173

SATB2
DNA-binding protein SATB2

1

20

High-throughput

0.536

High

637482

FLNA
Filamin-A

1

5

Small-scale

0.534

High

1057993

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

Small-scale

0.534

High

1091143

PITX2
Pituitary homeobox 2

1

15

Small-scale

0.515

High

1091169

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.513

High

706115

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

1091121

CE024
UPF0461 protein C5orf24

1

1

High-throughput

0.489

High

1091165

HPBP1
Hsp70-binding protein 1

1

8

High-throughput

0.489

High

124771

AIP
AH receptor-interacting protein

1

4

High-throughput

0.479

High

129030

MEN1
Menin

1

4

High-throughput

0.479

High

154680

ARI1A
AT-rich interactive domain-containing protein 1A

1

18

High-throughput

0.479

High

175022

SC16A
Protein transport protein Sec16A

1

5

High-throughput

0.479

High

181509

TBXT
T-box transcription factor T

1

6

High-throughput

0.479

High

207514

DHX15
ATP-dependent RNA helicase DHX15

1

7

High-throughput

0.479

High

214794

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.479

High

224274

BUB3
Mitotic checkpoint protein BUB3

1

6

High-throughput

0.479

High

224992

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

239948

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

246566

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

249609

SNX3
Sorting nexin-3

1

3

High-throughput

0.479

High

270348

WDR1
WD repeat-containing protein 1

1

6

High-throughput

0.479

High

272649

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

7

High-throughput

0.479

High

277668

H2AY
Core histone macro-H2A.1

1

8

High-throughput

0.479

High

278325

NCOR1
Nuclear receptor corepressor 1

1

20

High-throughput

0.479

High

289515

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

10

High-throughput

0.479

High

316830

MTA2
Metastasis-associated protein MTA2

1

10

High-throughput

0.479

High

431109

LA
Lupus La protein

1

4

High-throughput

0.479

High

442309

GELS
Gelsolin

1

1

High-throughput

0.479

High

447749

TPM3
Tropomyosin alpha-3 chain

1

5

High-throughput

0.479

High

466025

ANXA6
Annexin A6

1

1

High-throughput

0.479

High

472692

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

479806

GSTP1
Glutathione S-transferase P

1

4

High-throughput

0.479

High

481263

HMGB1
High mobility group protein B1

1

20

High-throughput

0.479

High

485101

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

8

High-throughput

0.479

High

487250

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.479

High

552799

TPR
Nucleoprotein TPR

1

10

High-throughput

0.479

High

576224

PO2F1
POU domain, class 2, transcription factor 1

1

17

High-throughput

0.479

High

576378

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

4

High-throughput

0.479

High

634421

LMNB1
Lamin-B1

1

6

High-throughput

0.479

High

643811

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

655175

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

High-throughput

0.479

High

659218

SP100
Nuclear autoantigen Sp-100

1

20

High-throughput

0.479

High

659772

SAHH
Adenosylhomocysteinase

1

9

High-throughput

0.479

High

662222

PAX7
Paired box protein Pax-7

1

15

High-throughput

0.479

High

662417

GATA2
Endothelial transcription factor GATA-2

1

15

High-throughput

0.479

High

662570

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

15

High-throughput

0.479

High

669885

MCM3
DNA replication licensing factor MCM3

1

7

High-throughput

0.479

High

685180

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

687230

HMGB2
High mobility group protein B2

1

20

High-throughput

0.479

High

695328

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

703132

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

712195

TKT
Transketolase

1

2

High-throughput

0.479

High

717296

PEBP1
Phosphatidylethanolamine-binding protein 1

1

3

High-throughput

0.479

High

724931

HXA10
Homeobox protein Hox-A10

1

20

High-throughput

0.479

High

725253

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

729040

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

10

High-throughput

0.479

High

755898

MCM5
DNA replication licensing factor MCM5

1

5

High-throughput

0.479

High

756171

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.479

High

775658

DEK
Protein DEK

1

1

High-throughput

0.479

High

775837

HNF1B
Hepatocyte nuclear factor 1-beta

1

18

High-throughput

0.479

High

776064

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

776183

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

794462

RBMX
RNA-binding motif protein, X chromosome

1

9

High-throughput

0.479

High

799869

COIL
Coilin

1

1

High-throughput

0.479

High

818734

CAPG
Macrophage-capping protein

1

1

High-throughput

0.479

High

827762

STAT3
Signal transducer and activator of transcription 3

1

2

High-throughput

0.479

High

833933

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

837588

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

846268

MATR3
Matrin-3

1

3

High-throughput

0.479

High

862086

YAP1
Transcriptional coactivator YAP1

1

11

Small-scale

0.479

High

886808

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

High-throughput

0.479

High

888017

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.479

High

892556

DNLI3
DNA ligase 3

1

5

High-throughput

0.479

High

903146

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

High-throughput

0.479

High

903342

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

High-throughput

0.479

High

908390

HDGF
Hepatoma-derived growth factor

1

7

High-throughput

0.479

High

910299

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.479

High

910480

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.479

High

913310

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.479

High

938443

PAX9
Paired box protein Pax-9

1

9

High-throughput

0.479

High

959572

MAX
Protein max

1

11

High-throughput

0.479

High

971461

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.479

High

979576

H4
Histone H4

1

6

High-throughput

0.479

High

997304

TBB4B
Tubulin beta-4B chain

1

5

High-throughput

0.479

High

998262

H31
Histone H3.1

1

11

High-throughput

0.479

High

1005855

GTF2I
General transcription factor II-I

1

1

High-throughput

0.479

High

1008118

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.479

High

1016814

H33
Histone H3.3

1

11

High-throughput

0.479

High

1029817

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

1032929

EWS
RNA-binding protein EWS

1

6

High-throughput

0.479

High

1039488

TOP2B
DNA topoisomerase 2-beta

1

10

High-throughput

0.479

High

1047961

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

1051915

KPCD
Protein kinase C delta type

1

7

High-throughput

0.479

High

1052864

HME1
Homeobox protein engrailed-1

1

11

High-throughput

0.479

High

1060954

SRSF1
Serine/arginine-rich splicing factor 1

1

7

High-throughput

0.479

High

1062429

DHX9
ATP-dependent RNA helicase A

1

4

High-throughput

0.479

High

1065163

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.479

High

1067245

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1088648

SF3A3
Splicing factor 3A subunit 3

1

1

High-throughput

0.479

High

1089623

ILF3
Interleukin enhancer-binding factor 3

1

15

High-throughput

0.479

High

1091094

TADBP
TAR DNA-binding protein 43

1

5

High-throughput

0.479

High

1091095

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

8

High-throughput

0.479

High

1091096

CTBP1
C-terminal-binding protein 1

1

8

High-throughput

0.479

High

1091097

IKZF1
DNA-binding protein Ikaros

1

3

High-throughput

0.479

High

1091098

PEBB
Core-binding factor subunit beta

1

1

High-throughput

0.479

High

1091099

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

1091100

MCM6
DNA replication licensing factor MCM6

1

7

High-throughput

0.479

High

1091101

SMC1A
Structural maintenance of chromosomes protein 1A

1

17

High-throughput

0.479

High

1091102

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.479

High

1091104

NUMA1
Nuclear mitotic apparatus protein 1

1

5

High-throughput

0.479

High

1091105

NONO
Non-POU domain-containing octamer-binding protein

1

8

High-throughput

0.479

High

1091107

ELAV1
ELAV-like protein 1

1

3

High-throughput

0.479

High

1091108

CEBPE
CCAAT/enhancer-binding protein epsilon

1

8

High-throughput

0.479

High

1091110

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.479

High

1091111

RBBP7
Histone-binding protein RBBP7

1

7

High-throughput

0.479

High

1091112

SRSF7
Serine/arginine-rich splicing factor 7

1

8

High-throughput

0.479

High

1091113

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

12

High-throughput

0.479

High

1091115

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

8

High-throughput

0.479

High

1091118

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1091120

I2BP2
Interferon regulatory factor 2-binding protein 2

1

6

High-throughput

0.479

High

1091125

SMC5
Structural maintenance of chromosomes protein 5

1

14

High-throughput

0.479

High

1091126

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

Small-scale

0.479

High

1091127

SMRC2
SWI/SNF complex subunit SMARCC2

1

19

High-throughput

0.479

High

1091129

SP7
Transcription factor Sp7

1

11

High-throughput

0.479

High

1091131

PSPC1
Paraspeckle component 1

1

8

High-throughput

0.479

High

1091133

DDX17
Probable ATP-dependent RNA helicase DDX17

1

4

High-throughput

0.479

High

1091134

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

5

High-throughput

0.479

High

1091135

FUBP2
Far upstream element-binding protein 2

1

16

High-throughput

0.479

High

1091136

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

High-throughput

0.479

High

1091137

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

17

High-throughput

0.479

High

1091138

FUBP1
Far upstream element-binding protein 1

1

17

High-throughput

0.479

High

1091139

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.479

High

1091140

ANM6
Protein arginine N-methyltransferase 6

1

4

High-throughput

0.479

High

1091141

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1091144

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1091145

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1091148

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

4

High-throughput

0.479

High

1091149

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

12

High-throughput

0.479

High

1091150

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.479

High

1091151

KLF16
Krueppel-like factor 16

1

11

High-throughput

0.479

High

1091152

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

12

High-throughput

0.479

High

1091153

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1091154

ADNP
Activity-dependent neuroprotector homeobox protein

1

4

High-throughput

0.479

High

1091157

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1091159

RC3H2
Roquin-2

1

16

High-throughput

0.479

High

1091160

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

1091163

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1091167

RCC2
Protein RCC2

1

6

High-throughput

0.479

High

1091168

DACH1
Dachshund homolog 1

1

5

High-throughput

0.479

High

1091170

FBW1B
F-box/WD repeat-containing protein 11

1

8

High-throughput

0.479

High

1091171

RALY
RNA-binding protein Raly

1

11

High-throughput

0.479

High

1091172

PRP19
Pre-mRNA-processing factor 19

1

11

High-throughput

0.479

High

1091174

SMC3
Structural maintenance of chromosomes protein 3

1

17

High-throughput

0.479

High

65743

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.458

High

228242

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

615535

NELFE
Negative elongation factor E

1

0

High-throughput

0.458

High

712855

CASP1
Caspase-1

1

0

High-throughput

0.458

High

791007

TALDO
Transaldolase

1

0

High-throughput

0.458

High

901213

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

925911

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.458

High

1046660

GLGB
1,4-alpha-glucan-branching enzyme

1

0

High-throughput

0.458

High

1091130

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1091176

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.458

High

1091177

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.458

High

1091161

PODO
Podocin

1

6

Small-scale

0.457

High

91867

C9JWJ8
Nuclear factor 1

1

20

High-throughput

0.445

High

369671

A2MG
Alpha-2-macroglobulin

1

7

High-throughput

0.437

High

501817

CO4A
Complement C4-A

1

7

High-throughput

0.437

High

958764

ARF3
ADP-ribosylation factor 3

1

3

High-throughput

0.437

High

1091114

FKB15
FK506-binding protein 15

1

3

High-throughput

0.437

High

1091156

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1091175

LC7L2
Putative RNA-binding protein Luc7-like 2

1

2

High-throughput

0.437

High

1091123

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.279

Low

1091109

Q16075
Oct-1B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025