Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1
Interactor 2: MED25 (Q71SY5)
Mediator of RNA polymerase II transcription subunit 25 (Activator interaction domain-containing protein 1) (Activator-recruited cofactor 92 kDa component) (ARC92) (Mediator complex subunit 25) (p78)
Gene: MED25
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.78 | 0.60 | 0.688 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 31527615, 24960263, 17641689, unassigned1953 |
| Identification Methods | affinity chromatography technology, two hybrid, tandem affinity purification |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001223 - transcription coactivator binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex and 2 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
