HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: ELAV1 (Q15717)
ELAV-like protein 1 (Hu-antigen R) (HuR)
Gene: ELAVL1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	33731348, 18279945
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 326
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (6-240): 1.05e-46: 168: 21.34
+	Hs
		368886 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP1_HUMAN (234-325): 2.15e-20: 93.5: 19.57
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (234-324): 4.16e-20: 92.8: 19.78
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (234-325): 3.78e-18: 87: 17.39
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (6-240): 1.05e-46: 168: 21.34
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (6-240): 1.05e-46: 168: 21.34
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (234-324): 4.16e-20: 92.8: 19.78
+	Hs
		611434 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP4_HUMAN (6-240): 1.05e-46: 168: 21.34
+	Hs
		1269600 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP3_HUMAN (234-325): 3.78e-18: 87: 17.39
+	Hs
		377286 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ELAV2_HUMAN (212-322): 4.72e-22: 97: 25.23
+	Hs
		516359 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP1_HUMAN (234-325): 2.15e-20: 93.5: 19.57
+	Hs
		487470 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ELAV1_HUMAN (1-326): 8.27e-90: 273: 100.00
+	Mm
		509289 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		PABP1_MOUSE (234-325): 2.2e-20: 93.5: 19.57
+	Hs
		487081 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PABP1_HUMAN (234-325): 2.15e-20: 93.5: 19.57