Protein: CO5
Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5b (Complement C5 alpha' chain)]

Gene: CO5, C5
Organism: Homo sapiens
Interactions: 35
UniProt ID: P01031

Gene Ontology (top 5):
GO:0004866 - endopeptidase inhibitor activity
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005579 - membrane attack complex
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369964

CO6
Complement component C6

2

10

Small-scale

0.778

High

210641

KLK10
Kallikrein-10

1

8

High-throughput

0.691

High

369969

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.691

High

369796

CO3
Complement C3

1

4

Small-scale

0.647

High

369961

CO8B
Complement component C8 beta chain

1

7

Small-scale

0.647

High

369963

CO7
Complement component C7

1

13

Small-scale

0.647

High

369967

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

8

Small-scale

0.647

High

181222

PGRC2
Membrane-associated progesterone receptor component 2

2

0

High-throughput

0.580

High

369975

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

2

1

High-throughput

0.553

High

369978

EMC5
ER membrane protein complex subunit 5

2

1

High-throughput

0.553

High

369979

KI3L3
Killer cell immunoglobulin-like receptor 3DL3

2

2

High-throughput

0.553

High

369982

CBPB2
Carboxypeptidase B2

1

3

Small-scale

0.501

High

369974

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

3

High-throughput

0.489

High

369977

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.489

High

369983

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

5

High-throughput

0.489

High

369985

PHF11
PHD finger protein 11

1

5

High-throughput

0.489

High

369962

CATB
Cathepsin B

1

1

Small-scale

0.479

High

369965

TIMP2
Metalloproteinase inhibitor 2

1

2

High-throughput

0.479

High

369966

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

369986

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.445

High

277225

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

360699

COX3
Cytochrome c oxidase subunit 3

1

3

Small-scale

0.437

High

369959

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.437

High

369960

GCR
Glucocorticoid receptor

1

5

High-throughput

0.437

High

369970

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.437

High

155540

NEMP1
Nuclear envelope integral membrane protein 1

2

0

High-throughput

0.316

High

369968

KELL
Kell blood group glycoprotein

2

0

High-throughput

0.316

High

369971

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.316

High

369972

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

369973

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.316

High

369976

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

369980

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.316

High

369981

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

1

0

High-throughput

0.299

High

369958

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

369984

VEZA
Vezatin

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025