HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	33731348, 21182205
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 482
+	Hs
		369532 ESR1_HUMAN (1-595): 0: 599: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		369663 ESR1_HUMAN (1-595): 0: 599: 100.00		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		369583 ESR1_HUMAN (1-595): 0: 599: 100.00		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		377805 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Mm
		509312 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		G3BP1_MOUSE (1-455): 2.96e-81: 261: 58.50
+	Hs
		1073538 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		1049498 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		1269282 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		740523 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		487398 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		487460 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43