Protein: FOSL2
Fos-related antigen 2 (FRA-2)

Gene: FOSL2
Organism: Homo sapiens
Interactions: 139
UniProt ID: P15408

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000902 - cell morphogenesis
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

429243

JUN
Transcription factor Jun

10

20

Small-scale

0.977

High

584083

CREB5
Cyclic AMP-responsive element-binding protein 5

8

20

High-throughput

0.974

High

584058

JUNB
Transcription factor JunB

9

20

Small-scale

0.973

High

583427

ATF2
Cyclic AMP-dependent transcription factor ATF-2

6

19

High-throughput

0.948

High

584059

JUND
Transcription factor JunD

6

20

High-throughput

0.947

High

584060

ATF7
Cyclic AMP-dependent transcription factor ATF-7

6

20

High-throughput

0.947

High

584141

BACH2
Transcription regulator protein BACH2

5

20

High-throughput

0.926

High

584099

NF2L2
Nuclear factor erythroid 2-related factor 2

1

20

Small-scale

0.778

High

584071

DDIT3
DNA damage-inducible transcript 3 protein

5

14

High-throughput

0.725

High

584124

COP1
E3 ubiquitin-protein ligase COP1

5

12

High-throughput

0.716

High

584120

STK40
Serine/threonine-protein kinase 40

4

20

Small-scale

0.694

High

225469

CYH3
Cytohesin-3

4

7

High-throughput

0.691

High

274090

ANR17
Ankyrin repeat domain-containing protein 17

4

8

High-throughput

0.691

High

584113

I2BP2
Interferon regulatory factor 2-binding protein 2

4

9

High-throughput

0.691

High

584117

I2BP1
Interferon regulatory factor 2-binding protein 1

4

4

High-throughput

0.691

High

584126

KBTB7
Kelch repeat and BTB domain-containing protein 7

4

8

High-throughput

0.691

High

584144

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

4

9

High-throughput

0.691

High

340292

YETS4
YEATS domain-containing protein 4

3

4

High-throughput

0.667

High

584112

DET1
DET1 homolog

3

3

High-throughput

0.667

High

584116

FBX11
F-box only protein 11

3

2

High-throughput

0.667

High

584118

ANKH1
Ankyrin repeat and KH domain-containing protein 1

3

8

High-throughput

0.667

High

584135

TRIB1
Tribbles homolog 1

3

17

High-throughput

0.667

High

584155

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

3

3

High-throughput

0.667

High

584063

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

High-throughput

0.647

High

584171

MAFB
Transcription factor MafB

1

20

High-throughput

0.647

High

584123

NBEA
Neurobeachin

4

1

High-throughput

0.630

High

584161

TSR3
18S rRNA aminocarboxypropyltransferase

4

1

High-throughput

0.630

High

584098

USF2
Upstream stimulatory factor 2

2

20

High-throughput

0.628

High

584156

BAHC1
BAH and coiled-coil domain-containing protein 1

2

2

High-throughput

0.628

High

584093

FHL3
Four and a half LIM domains protein 3

2

4

High-throughput

0.628

High

584061

CEBPB
CCAAT/enhancer-binding protein beta

1

20

High-throughput

0.618

High

584074

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.618

High

584062

EGR1
Early growth response protein 1

2

8

High-throughput

0.611

High

584067

EF1D
Elongation factor 1-delta

2

8

High-throughput

0.611

High

584115

CARM1
Histone-arginine methyltransferase CARM1

2

3

High-throughput

0.611

High

207792

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

3

1

High-throughput

0.609

High

584066

SYVC
Valine--tRNA ligase

3

5

High-throughput

0.609

High

584103

HECD3
E3 ubiquitin-protein ligase HECTD3

3

4

High-throughput

0.609

High

584137

RUFY1
RUN and FYVE domain-containing protein 1

3

3

High-throughput

0.609

High

584138

CYH2
Cytohesin-2

3

7

High-throughput

0.609

High

584102

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

1

High-throughput

0.606

High

584106

LHX8
LIM/homeobox protein Lhx8

2

4

High-throughput

0.606

High

584169

NDK7
Nucleoside diphosphate kinase homolog 7

2

2

High-throughput

0.606

High

584085

MECOM
Histone-lysine N-methyltransferase MECOM

2

9

Small-scale

0.594

High

584091

TRAF1
TNF receptor-associated factor 1

2

4

High-throughput

0.594

High

584072

BRCA1
Breast cancer type 1 susceptibility protein

2

6

High-throughput

0.584

High

584079

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.580

High

584151

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

4

High-throughput

0.573

High

584130

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.573

High

584154

LUZP4
Leucine zipper protein 4

1

3

High-throughput

0.573

High

395429

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

584097

CYH1
Cytohesin-1

2

7

High-throughput

0.553

High

316249

RECQ5
ATP-dependent DNA helicase Q5

1

3

High-throughput

0.536

High

584140

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.536

High

584158

SPAST
Spastin

1

1

High-throughput

0.536

High

374380

RASH
GTPase HRas

1

5

High-throughput

0.515

High

584065

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.515

High

584107

Q6FHY5
MEOX2 protein

1

8

High-throughput

0.515

High

71427

P20L1
PHD finger protein 20-like protein 1

1

0

High-throughput

0.513

High

584081

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

584082

LSM11
U7 snRNA-associated Sm-like protein LSm11

1

0

High-throughput

0.513

High

584142

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.513

High

584146

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.513

High

584166

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.513

High

584088

EP300
Histone acetyltransferase p300

1

19

Small-scale

0.501

High

584150

SRA1
Steroid receptor RNA activator 1

1

5

Small-scale

0.501

High

584162

DNM3L
DNA

1

7

Small-scale

0.501

High

584164

UBQL1
Ubiquilin-1

1

0

High-throughput

0.493

High

584077

MEOX2
Homeobox protein MOX-2

1

8

High-throughput

0.481

High

584132

GMCL1
Germ cell-less protein-like 1

1

6

High-throughput

0.481

High

128753

MEN1
Menin

1

6

High-throughput

0.479

High

519712

ANDR
Androgen receptor

1

18

High-throughput

0.479

High

584064

IL11
Interleukin-11

1

1

Small-scale

0.479

High

584069

ELF1
ETS-related transcription factor Elf-1

1

7

Small-scale

0.479

High

584070

NOS2
Nitric oxide synthase, inducible

1

1

Small-scale

0.479

High

584080

H4
Histone H4

1

7

High-throughput

0.479

High

584114

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

7

High-throughput

0.479

High

584133

ANM6
Protein arginine N-methyltransferase 6

1

3

High-throughput

0.479

High

442222

GELS
Gelsolin

1

3

High-throughput

0.470

High

584101

Q53SE7
Germ cell-less homolog 1

1

6

High-throughput

0.470

High

259382

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.445

High

283652

GPC4
Glypican-4

1

2

High-throughput

0.445

High

371072

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.445

High

460908

LDHC
L-lactate dehydrogenase C chain

1

3

High-throughput

0.445

High

584075

YLPM1
YLP motif-containing protein 1

1

1

High-throughput

0.445

High

584084

ENL
Protein ENL

1

20

High-throughput

0.445

High

584089

TBL3
Transducin beta-like protein 3

1

6

High-throughput

0.445

High

584090

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.445

High

584094

C1D
Nuclear nucleic acid-binding protein C1D

1

1

High-throughput

0.445

High

584095

WDR43
WD repeat-containing protein 43

1

4

High-throughput

0.445

High

584104

RBM26
RNA-binding protein 26

1

3

High-throughput

0.445

High

584109

CTR9
RNA polymerase-associated protein CTR9 homolog

1

4

High-throughput

0.445

High

584110

DNMBP
Dynamin-binding protein

1

2

High-throughput

0.445

High

584119

PHC2
Polyhomeotic-like protein 2

1

3

High-throughput

0.445

High

584129

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

High-throughput

0.445

High

584134

IFT74
Intraflagellar transport protein 74 homolog

1

6

High-throughput

0.445

High

584139

DIDO1
Death-inducer obliterator 1

1

16

High-throughput

0.445

High

584157

RBM27
RNA-binding protein 27

1

3

High-throughput

0.445

High

584163

TNIK
TRAF2 and NCK-interacting protein kinase

1

4

High-throughput

0.445

High

584165

SCAF8
SR-related and CTD-associated factor 8

1

1

High-throughput

0.445

High

584168

ARI1
E3 ubiquitin-protein ligase ARIH1

1

7

High-throughput

0.445

High

584170

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

3

High-throughput

0.445

High

584172

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

2

High-throughput

0.445

High

584096

EEA1
Early endosome antigen 1

1

3

High-throughput

0.437

High

251295

NEMF
Ribosome quality control complex subunit NEMF

1

0

High-throughput

0.426

High

584076

DNLI3
DNA ligase 3

1

0

High-throughput

0.426

High

584086

CENPC
Centromere protein C

1

0

High-throughput

0.426

High

584087

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

584092

RED
Protein Red

1

0

High-throughput

0.426

High

584100

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

584105

RSBN1
Lysine-specific demethylase 9

1

0

High-throughput

0.426

High

584122

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.426

High

584125

LEO1
RNA polymerase-associated protein LEO1

1

0

High-throughput

0.426

High

584131

THOC1
THO complex subunit 1

1

0

High-throughput

0.426

High

584136

RBM15
RNA-binding protein 15

1

0

High-throughput

0.426

High

584143

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.426

High

584148

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.426

High

584153

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.426

High

584159

ZO2
Tight junction protein 2

1

0

High-throughput

0.426

High

116499

H7C0V5
ANKHD1-EIF4EBP3 readthrough

1

7

High-throughput

0.407

High

124888

GTPB1
GTP-binding protein 1

1

1

High-throughput

0.407

High

156915

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.407

High

229944

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.407

High

584111

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

2

High-throughput

0.407

High

584127

IFT81
Intraflagellar transport protein 81 homolog

1

6

High-throughput

0.407

High

584147

IFT22
Intraflagellar transport protein 22 homolog

1

3

High-throughput

0.407

High

584160

IF172
Intraflagellar transport protein 172 homolog

1

1

High-throughput

0.407

High

584128

SORL
Sortilin-related receptor

3

0

High-throughput

0.347

High

584057

STMN1
Stathmin

1

0

High-throughput

0.279

Low

584073

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.279

Low

584078

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.279

Low

48133

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.232

Low

584068

SDC4
Syndecan-4

1

0

High-throughput

0.232

Low

584108

TM214
Transmembrane protein 214

1

0

High-throughput

0.232

Low

584121

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.232

Low

584145

OSBL3
Oxysterol-binding protein-related protein 3

1

0

High-throughput

0.232

Low

584149

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.232

Low

584152

IFT46
Intraflagellar transport protein 46 homolog

1

0

High-throughput

0.232

Low

584167

IFT52
Intraflagellar transport protein 52 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025