HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: KDM2A (Q9Y2K7)
Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A)
Gene: KDM2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30118678
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1162
+	Hs
		1269974 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KDM2A_HUMAN (1-1162): 0: 1354: 100.00
+	Hs
		370049 ESR1_HUMAN (1-595): 0: 599: 100.00		KDM2B_HUMAN (15-1162): 0: 1040: 37.75
+	Hs
		1245580 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KDM2B_HUMAN (15-1162): 0: 1040: 37.75
+	Hs
		782597 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		KDM2B_HUMAN (15-1162): 0: 1040: 37.75
+	Hs
		377510 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		KDM2B_HUMAN (15-1162): 0: 1040: 37.75
+	Hs
		510029 ERR1_HUMAN (123-547): 6.94e-103: 319: 34.04		KDM2B_HUMAN (15-1162): 0: 1040: 37.75
+	Hs
		740559 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		KDM2B_HUMAN (15-1162): 0: 1040: 37.75
+	Hs
		487601 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		KDM2B_HUMAN (15-1162): 0: 1040: 37.75
+	Hs
		256376 ESR1_HUMAN (1-595): 0: 599: 100.00		PHF2_HUMAN (4-441): 4.67e-168: 528: 29.19
+	Hs
		256425 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PHF2_HUMAN (4-441): 4.67e-168: 528: 29.19
+	Hs
		1269941 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PHF8_HUMAN (12-406): 1.45e-164: 517: 37.69
+	Hs
		256388 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PHF2_HUMAN (4-441): 4.67e-168: 528: 29.19
+	Hs
		256426 NR1H4_HUMAN (48-547): 2.99e-109: 338: 20.68		PHF2_HUMAN (4-441): 4.67e-168: 528: 29.19
+	Hs
		488036 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		PHF8_HUMAN (12-406): 1.45e-164: 517: 37.69
+	Hs
		369449 ESR1_HUMAN (1-595): 0: 599: 100.00		KMT2A_HUMAN (360-609): 1.68e-47: 188: 20.73
+	Hs
		369533 ESR1_HUMAN (1-595): 0: 599: 100.00		SKP2_HUMAN (805-1151): 6.12e-48: 179: 19.24
+	Hs
		975296 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		KMT2A_HUMAN (360-609): 1.68e-47: 188: 20.73
+	Hs
		377262 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		KMT2A_HUMAN (360-609): 1.68e-47: 188: 20.73
+	Hs
		487351 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		KMT2A_HUMAN (360-609): 1.68e-47: 188: 20.73
+	Hs
		487399 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		SKP2_HUMAN (805-1151): 6.12e-48: 179: 19.24