HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: GRIP1 (Q9Y3R0)
Glutamate receptor-interacting protein 1 (GRIP-1)
Gene: GRIP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.658

Property	Details
Experiments	9773983, 17932106, 17545996
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008013 - beta-catenin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1128
+	Mm
		587109 ESR1_MOUSE (1-595): 0: 570: 88.98		GRIP1_MOUSE (1-1128): 0: 657: 95.83
+	Hs
		587206 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		GRIP1_HUMAN (1-1128): 0: 676: 100.00
+	Hs
		377826 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		GRIP1_HUMAN (1-1128): 0: 676: 100.00
+	Mm
		580486 ANDR_MOUSE (32-555): 1.51e-102: 332: 22.04		GRIP1_MOUSE (1-1128): 0: 657: 95.83
+	Mm
		509340 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		GRIP1_MOUSE (1-1128): 0: 657: 95.83
+	Hs
		370053 ESR1_HUMAN (1-595): 0: 599: 100.00		INADL_HUMAN (485-1124): 9.32e-43: 172: 17.42
+	Hs
		280012 ESR1_HUMAN (1-595): 0: 599: 100.00		MPDZ_HUMAN (12-236): 3.38e-34: 145: 21.92
+	Hs
		369500 ESR1_HUMAN (1-595): 0: 599: 100.00		PTN13_HUMAN (18-280): 1.38e-22: 107: 18.56
+	Hs
		369502 ESR1_HUMAN (1-595): 0: 599: 100.00		DLG1_HUMAN (9-377): 2.52e-17: 89.7: 13.17
+	Hs
		370138 ESR1_HUMAN (1-595): 0: 599: 100.00		DLG3_HUMAN (803-1120): 7.46e-15: 81.7: 14.15
+	Hs
		370532 ESR1_HUMAN (1-595): 0: 599: 100.00		LIN7C_HUMAN (149-246): 1.58e-09: 60.8: 35.71
+	Hs
		1246417 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		INADL_HUMAN (485-1124): 9.32e-43: 172: 17.42
+	Hs
		377778 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		ZO2_HUMAN (33-1124): 2.95e-51: 199: 12.79
+	Hs
		1050020 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SCRIB_HUMAN (673-1100): 2.61e-27: 122: 17.81
+	Hs
		1020200 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PTN13_HUMAN (18-280): 1.38e-22: 107: 18.56
+	Hs
		1021541 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DLG1_HUMAN (9-377): 2.52e-17: 89.7: 13.17
+	Hs
		280019 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		MPDZ_HUMAN (12-236): 3.38e-34: 145: 21.92
+	Hs
		1269730 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		LIN7C_HUMAN (149-246): 1.58e-09: 60.8: 35.71
+	Hs
		1050096 NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12		SCRIB_HUMAN (673-1100): 2.61e-27: 122: 17.81
+	Hs
		377728 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		LIN7C_HUMAN (149-246): 1.58e-09: 60.8: 35.71