HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	29467282, 35013218, 36424410, 21150319
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0043066 - negative regulation of apoptotic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 166
+	Hs
		371613 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		DEST_HUMAN (1-166): 3.72e-69: 208: 71.08
+	Hs
		371882 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		TWF1_HUMAN (3-157): 1.01e-34: 126: 21.52
+	Hs
		372296 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		TWF2_HUMAN (3-151): 2.3e-29: 111: 17.11
+	Hs
		405799 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		COF1_HUMAN (1-166): 4.48e-72: 215: 100.00
+	Hs
		405961 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		DEST_HUMAN (1-166): 3.72e-69: 208: 71.08