Protein: TWF2
Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein)

Gene: TWF2
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q6IBS0

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003785 - actin monomer binding
GO:0005080 - protein kinase C binding
GO:0005524 - ATP binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

952893

ACTB
Actin, cytoplasmic 1

3

20

High-throughput

0.871

High

995646

ACTC
Actin, alpha cardiac muscle 1

3

20

High-throughput

0.861

High

977727

ACTA
Actin, aortic smooth muscle

3

20

High-throughput

0.855

High

867209

CAPZB
F-actin-capping protein subunit beta

3

5

High-throughput

0.830

High

1200975

ACTBL
Beta-actin-like protein 2

2

20

High-throughput

0.811

High

993215

ACTG
Actin, cytoplasmic 2

2

20

High-throughput

0.789

High

1085890

TWF1
Twinfilin-1

2

13

High-throughput

0.737

High

1104420

ILK
Scaffold protein ILK

1

2

High-throughput

0.698

High

62963

POTEF
POTE ankyrin domain family member F

1

20

High-throughput

0.691

High

1233725

ARP3B
Actin-related protein 3B

1

20

High-throughput

0.665

High

818801

CAP2
Adenylyl cyclase-associated protein 2

3

10

High-throughput

0.662

High

1030738

CAP1
Adenylyl cyclase-associated protein 1

3

10

High-throughput

0.662

High

1233724

TMOD3
Tropomodulin-3

2

4

High-throughput

0.628

High

958452

ACTZ
Alpha-centractin

1

20

High-throughput

0.618

High

1196877

BCL7A
B-cell CLL/lymphoma 7 protein family member A

3

3

High-throughput

0.604

High

866723

CAZA2
F-actin-capping protein subunit alpha-2

2

6

High-throughput

0.588

High

506961

POTEI
POTE ankyrin domain family member I

1

20

High-throughput

0.575

High

1233711

BCL7C
B-cell CLL/lymphoma 7 protein family member C

2

3

High-throughput

0.574

High

277934

SH3L1
Adapter SH3BGRL

2

3

High-throughput

0.571

High

1233723

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.549

High

123733

MYO1C
Unconventional myosin-Ic

1

11

High-throughput

0.536

High

772857

MYH9
Myosin-9

1

4

High-throughput

0.536

High

1120457

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.536

High

1233728

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.536

High

300580

KRT36
Keratin, type I cuticular Ha6

1

4

High-throughput

0.515

High

915113

CAZA1
F-actin-capping protein subunit alpha-1

1

6

High-throughput

0.515

High

1145985

K1H1
Keratin, type I cuticular Ha1

1

4

High-throughput

0.515

High

1233705

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

11

High-throughput

0.515

High

1233706

VRK3
Serine/threonine-protein kinase VRK3

1

2

High-throughput

0.515

High

1140085

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

912578

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.508

High

1233720

POTE1
Protection of telomeres protein 1

1

3

High-throughput

0.504

High

1233712

FOXJ1
Forkhead box protein J1

1

1

High-throughput

0.494

High

426517

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

1233722

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.493

High

1233707

SYNPO
Synaptopodin

1

4

High-throughput

0.489

High

242001

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

247961

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

372296

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

537345

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

556155

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

1094568

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

High-throughput

0.479

High

1106580

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

1140420

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1233703

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1233710

STYX
Serine/threonine/tyrosine-interacting protein

1

6

High-throughput

0.479

High

1233715

WWTR1
WW domain-containing transcription regulator protein 1

1

5

High-throughput

0.479

High

1233716

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

1233727

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1007525

KRT85
Keratin, type II cuticular Hb5

1

2

High-throughput

0.470

High

1233718

KRT82
Keratin, type II cuticular Hb2

1

2

High-throughput

0.470

High

347759

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

620419

NUCL
Nucleolin

1

0

High-throughput

0.458

High

324924

HEXI1
Protein HEXIM1

1

3

High-throughput

0.445

High

1209264

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1233700

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

1233708

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1233719

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

1233729

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.445

High

106109

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

316891

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.437

High

588926

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

768430

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1197511

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.437

High

1233701

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

1233717

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.437

High

1233721

CCD87
Coiled-coil domain-containing protein 87

1

1

High-throughput

0.437

High

298189

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.426

High

404820

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1233713

PDD2L
Programmed cell death protein 2-like

1

0

High-throughput

0.426

High

608291

EGLN
Endoglin

1

1

High-throughput

0.407

High

1103990

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1233730

RN114
E3 ubiquitin-protein ligase RNF114

1

3

High-throughput

0.407

High

886950

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

421166

SCG1
Secretogranin-1

1

0

High-throughput

0.282

High

1233714

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.269

Low

1233704

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1233709

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

330201

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1219106

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

0

High-throughput

0.232

Low

1233702

TMM88
Transmembrane protein 88

1

0

High-throughput

0.232

Low

1233726

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025