HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	29467282, 30415952, 35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000165 - MAPK cascade GO:0005634 - nucleus GO:0005730 - nucleolus GO:0032991 - protein-containing complex GO:0044877 - protein-containing complex binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 323
+	Hs
		371648 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		371649 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Hs
		371715 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		PP2AA_HUMAN (8-312): 5.37e-178: 496: 46.08
+	Hs
		405979 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		648331 USF1_HUMAN (175-453): 3.38e-39: 145: 18.06		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Mm
		704109 MAX_MOUSE (354-454): 3.61e-25: 102: 32.67		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Hs
		786479 MAX_HUMAN (354-454): 1.4e-24: 101: 32.67		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Mm
		704107 MAX_MOUSE (354-454): 3.61e-25: 102: 32.67		PP1A_MOUSE (1-323): 0: 579: 90.36
+	Hs
		959550 MAX_HUMAN (354-454): 1.4e-24: 101: 32.67		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Mm
		704108 MAX_MOUSE (354-454): 3.61e-25: 102: 32.67		PP1B_MOUSE (1-322): 0: 560: 86.89
+	Hs
		959551 MAX_HUMAN (354-454): 1.4e-24: 101: 32.67		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Hs
		959552 MAX_HUMAN (354-454): 1.4e-24: 101: 32.67		PP2AB_HUMAN (8-312): 1.92e-178: 497: 46.73
+	Hs
		959555 MAX_HUMAN (354-454): 1.4e-24: 101: 32.67		PP2AA_HUMAN (8-312): 5.37e-178: 496: 46.08