Protein: GPN1
GPN-loop GTPase 1 (EC 3.6.5.-) (Essential PCL1-interacting ATPase 1) (GPN-loop GTPase NPA3) (Nucleolar preribosomal-associated protein 3)

Gene: GPN1, NPA3
Organism: Saccharomyces cerevisiae S288C
Interactions: 151
UniProt ID: P47122

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006606 - protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

812026

GPN2
GPN-loop GTPase 2

7

10

Small-scale

0.959

High

812021

GPN3
GPN-loop GTPase 3

5

10

Small-scale

0.936

High

811996

GPN1
GPN-loop GTPase 1

2

10

Small-scale

0.737

High

768158

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

5

3

Small-scale

0.713

High

440060

RPB2
DNA-directed RNA polymerase II subunit RPB2

10

13

Small-scale

0.685

High

558136

RPB3
DNA-directed RNA polymerase II subunit RPB3

7

8

Small-scale

0.672

High

375435

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

9

Small-scale

0.669

High

544022

HSC82
ATP-dependent molecular chaperone HSC82

3

3

High-throughput

0.640

High

757141

RPB11
DNA-directed RNA polymerase II subunit RPB11

4

7

Small-scale

0.612

High

676178

XPO1
Exportin-1

2

12

Small-scale

0.611

High

812017

RBA50
RNA polymerase II-associated protein RBA50

2

3

Small-scale

0.595

High

593161

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

3

Small-scale

0.585

High

366543

HSP82
ATP-dependent molecular chaperone HSP82

2

3

Small-scale

0.584

High

797457

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

606693

RPC2
DNA-directed RNA polymerase III subunit RPC2

3

13

Small-scale

0.581

High

593331

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

3

Small-scale

0.576

High

494349

HSP72
Heat shock protein SSA2

2

4

Small-scale

0.571

High

511867

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

Small-scale

0.571

High

588139

HSP60
Heat shock protein 60, mitochondrial

2

1

Small-scale

0.571

High

753868

RPN1
26S proteasome regulatory subunit RPN1

2

1

High-throughput

0.571

High

624638

PCL1
PHO85 cyclin-1

1

0

Small-scale

0.561

High

594339

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.536

High

604701

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

4

High-throughput

0.533

High

655571

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

5

Small-scale

0.514

High

412998

KAPB
cAMP-dependent protein kinase type 2

1

0

High-throughput

0.513

High

539379

KSS1
Mitogen-activated protein kinase KSS1

1

0

High-throughput

0.513

High

540000

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.513

High

691233

MKK2
MAP kinase kinase MKK2/SSP33

1

0

High-throughput

0.513

High

812003

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.513

High

812018

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.513

High

565678

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

648205

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.480

High

811999

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.480

High

407162

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

426034

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

478327

HSP77
Import motor subunit, mitochondrial

1

2

Small-scale

0.479

High

485764

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.479

High

491710

HSP71
Heat shock protein SSA1

1

4

Small-scale

0.479

High

593250

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

3

High-throughput

0.479

High

680837

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

695020

HSP7F
Heat shock protein homolog SSE1

1

6

Small-scale

0.479

High

698864

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

710022

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

4

High-throughput

0.479

High

768830

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

Small-scale

0.479

High

772999

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

5

High-throughput

0.479

High

811997

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

812012

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.479

High

812027

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

812031

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.479

High

812032

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.479

High

141416

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

407998

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

413594

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

471142

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

472277

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

657171

PYRD
Dihydroorotate dehydrogenase

1

0

Small-scale

0.458

High

706362

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

728275

DEF1
RNA polymerase II degradation factor 1

1

0

Small-scale

0.458

High

731061

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

734022

NU133
Nucleoporin NUP133

1

0

Small-scale

0.458

High

737181

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

752543

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

774477

MOB1
DBF2 kinase activator protein MOB1

1

0

High-throughput

0.458

High

797204

BUD27
Bud site selection protein 27

1

0

High-throughput

0.458

High

810331

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

0

High-throughput

0.458

High

811166

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

812004

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.458

High

812007

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

812010

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

812011

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

812015

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

812022

ASR1
Alcohol-sensitive RING finger protein 1

1

0

High-throughput

0.458

High

812023

SUB2
ATP-dependent RNA helicase SUB2

1

0

High-throughput

0.458

High

812024

SGO1
Shugoshin

1

0

High-throughput

0.458

High

812025

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

812030

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

689416

RNP1
Ribonucleoprotein 1

1

1

High-throughput

0.457

High

704553

PPZ2
Serine/threonine-protein phosphatase PP-Z2

1

1

High-throughput

0.457

High

399536

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.445

High

424594

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

687423

EF2
Elongation factor 2

1

1

High-throughput

0.445

High

703924

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

High-throughput

0.445

High

760647

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.445

High

785092

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.445

High

812008

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.445

High

409850

NOT2
General negative regulator of transcription subunit 2

1

0

High-throughput

0.438

High

636022

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.438

High

710342

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.438

High

758390

SNF11
Transcription regulatory protein SNF11

1

0

High-throughput

0.438

High

763755

GCSH
Glycine cleavage system H protein, mitochondrial

1

0

High-throughput

0.438

High

765192

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.438

High

771704

YG5N
Uncharacterized protein YGR269W

1

0

High-throughput

0.438

High

775362

HIS4
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

1

0

High-throughput

0.438

High

797290

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.438

High

809804

NMD5
Nonsense-mediated mRNA decay protein 5

1

0

High-throughput

0.438

High

812001

POP6
Ribonucleases P/MRP protein subunit POP6

1

0

High-throughput

0.438

High

812016

EMI2
Putative glucokinase-2

1

0

High-throughput

0.438

High

375618

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

9

Small-scale

0.437

High

429734

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

8

Small-scale

0.437

High

501383

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

9

Small-scale

0.437

High

604581

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

13

Small-scale

0.437

High

650332

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.437

High

662662

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

812014

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

High-throughput

0.437

High

360939

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

368195

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

498547

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.426

High

556145

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

704684

PRP8
Pre-mRNA-splicing factor 8

1

0

High-throughput

0.426

High

756968

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.426

High

796913

GCN20
Protein GCN20

1

0

High-throughput

0.426

High

812013

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.426

High

693327

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.407

High

605557

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.279

Low

697303

RAD24
Checkpoint protein RAD24

1

0

High-throughput

0.279

Low

744644

TAF5
Transcription initiation factor TFIID subunit 5

1

0

High-throughput

0.279

Low

614715

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.261

Low

623840

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

0

High-throughput

0.261

Low

568124

TPM1
Tropomyosin-1

1

0

Small-scale

0.249

Low

710898

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.249

Low

716461

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

776454

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

784854

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.249

Low

784870

T2FB
Transcription initiation factor IIF subunit beta

1

0

High-throughput

0.249

Low

812005

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

812020

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

812028

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

373268

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.238

Low

427949

PT494
COX3 mRNA-specific translational activator PET494

1

0

High-throughput

0.238

Low

500611

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.238

Low

547414

CUP2
Transcriptional activator protein CUP2

1

0

High-throughput

0.238

Low

575894

ADT3
ADP,ATP carrier protein 3

1

0

High-throughput

0.238

Low

606802

QCR9
Cytochrome b-c1 complex subunit 9, mitochondrial

1

0

High-throughput

0.238

Low

686854

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.238

Low

691324

NGG1
Chromatin-remodeling complexes subunit NGG1

1

0

High-throughput

0.238

Low

698316

COX13
Cytochrome c oxidase subunit 13, mitochondrial

1

0

High-throughput

0.238

Low

754280

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.238

Low

754300

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.238

Low

755562

ERP5
Protein ERP5

1

0

High-throughput

0.238

Low

774924

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.238

Low

775312

YIC9
Uncharacterized protein YIL029C

1

0

High-throughput

0.238

Low

796988

AAD6
Putative aryl-alcohol dehydrogenase AAD6

1

0

High-throughput

0.238

Low

797175

BST1
GPI inositol-deacylase

1

0

High-throughput

0.238

Low

811998

YGW8
Putative uncharacterized protein YGL218W

1

0

High-throughput

0.238

Low

812000

YGP2
Putative uncharacterized protein YGL152C

1

0

High-throughput

0.238

Low

812002

FHN1
Non-classical export protein 2 homolog 1

1

0

High-throughput

0.238

Low

812006

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

High-throughput

0.238

Low

812009

SRL4
Oxidoreductase-like protein SRL4

1

0

High-throughput

0.238

Low

812019

ORM2
Protein ORM2

1

0

High-throughput

0.238

Low

812029

SAS10
Something about silencing protein 10

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024