Protein: MAX
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)

Gene: MAX
Organism: Homo sapiens
Interactions: 225
UniProt ID: P61244

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

371628

MYC
Myc proto-oncogene protein

71

18

Small-scale

0.997

High

896187

MXI1
Max-interacting protein 1

14

20

Small-scale

0.985

High

959568

MAD1
Max dimerization protein 1

16

18

Small-scale

0.984

High

405963

MYCN
N-myc proto-oncogene protein

15

17

Small-scale

0.983

High

959647

MAD3
Max dimerization protein 3

9

18

Small-scale

0.972

High

959643

MNT
Max-binding protein MNT

7

19

Small-scale

0.969

High

959582

MAD4
Max dimerization protein 4

7

19

Small-scale

0.965

High

959548

MAX
Protein max

8

18

Small-scale

0.959

High

959614

MGAP
MAX gene-associated protein

6

6

High-throughput

0.955

High

553742

MYCL
Protein L-Myc

4

18

Small-scale

0.893

High

959685

TRRAP
Transformation/transcription domain-associated protein

7

14

Small-scale

0.747

High

959649

PCGF6
Polycomb group RING finger protein 6

7

16

Small-scale

0.746

High

959630

LMBL2
Lethal(3)malignant brain tumor-like protein 2

6

7

Small-scale

0.736

High

959579

TFDP1
Transcription factor Dp-1

5

3

Small-scale

0.723

High

282693

E2F6
Transcription factor E2F6

5

6

Small-scale

0.718

High

959636

EP400
E1A-binding protein p400

5

20

Small-scale

0.718

High

959639

RING2
E3 ubiquitin-protein ligase RING2

5

20

Small-scale

0.718

High

277623

H2AY
Core histone macro-H2A.1

1

10

High-throughput

0.715

High

814775

CUX1
Homeobox protein cut-like 1

1

11

High-throughput

0.698

High

959586

TWST1
Twist-related protein 1

1

11

High-throughput

0.691

High

959606

FOXR2
Forkhead box protein R2

3

13

High-throughput

0.675

High

959571

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.670

High

959615

YAF2
YY1-associated factor 2

3

4

Small-scale

0.667

High

959617

RYBP
RING1 and YY1-binding protein

3

4

Small-scale

0.667

High

959638

SIN3A
Paired amphipathic helix protein Sin3a

3

12

Small-scale

0.667

High

959592

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.665

High

959645

EPAS1
Endothelial PAS domain-containing protein 1

1

8

Small-scale

0.665

High

340312

YETS4
YEATS domain-containing protein 4

3

5

Small-scale

0.656

High

959549

WDR5
WD repeat-containing protein 5

3

20

High-throughput

0.656

High

959570

RING1
E3 ubiquitin-protein ligase RING1

3

17

Small-scale

0.656

High

959574

CBX3
Chromobox protein homolog 3

3

14

Small-scale

0.656

High

959628

KAT5
Histone acetyltransferase KAT5

3

8

Small-scale

0.656

High

959667

DMAP1
DNA methyltransferase 1-associated protein 1

3

4

Small-scale

0.656

High

959653

BRD8
Bromodomain-containing protein 8

3

20

Small-scale

0.640

High

833716

KDM5C
Lysine-specific demethylase 5C

2

3

Small-scale

0.628

High

959559

CBX1
Chromobox protein homolog 1

2

14

High-throughput

0.628

High

959634

REXO5
RNA exonuclease 5

2

11

High-throughput

0.628

High

959652

SP130
Histone deacetylase complex subunit SAP130

2

10

High-throughput

0.628

High

886702

CEBPA
CCAAT/enhancer-binding protein alpha

2

20

Small-scale

0.624

High

959556

CSK21
Casein kinase II subunit alpha

2

13

Small-scale

0.619

High

132710

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

8

High-throughput

0.618

High

192907

CLOCK
Circadian locomoter output cycles protein kaput

1

8

High-throughput

0.618

High

648342

USF1
Upstream stimulatory factor 1

1

18

Small-scale

0.618

High

959561

H33
Histone H3.3

1

8

High-throughput

0.618

High

959567

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.618

High

959569

MBTD1
MBT domain-containing protein 1

2

7

Small-scale

0.611

High

959587

VPS72
Vacuolar protein sorting-associated protein 72 homolog

2

2

Small-scale

0.611

High

959595

EPC2
Enhancer of polycomb homolog 2

2

7

Small-scale

0.611

High

959654

EPC1
Enhancer of polycomb homolog 1

2

7

Small-scale

0.611

High

959671

ING3
Inhibitor of growth protein 3

2

8

Small-scale

0.611

High

959679

FBW1B
F-box/WD repeat-containing protein 11

2

20

High-throughput

0.611

High

959682

RUVB2
RuvB-like 2

2

9

Small-scale

0.611

High

959657

PKHF2
Pleckstrin homology domain-containing family F member 2

3

4

High-throughput

0.609

High

959576

BFSP2
Phakinin

3

14

High-throughput

0.604

High

959626

KAT2A
Histone acetyltransferase KAT2A

2

20

Small-scale

0.584

High

959675

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.584

High

391600

FRIH
Ferritin heavy chain

1

6

High-throughput

0.578

High

959655

UN45A
Protein unc-45 homolog A

2

10

High-throughput

0.573

High

317155

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

10

Small-scale

0.561

High

703114

TEAD1
Transcriptional enhancer factor TEF-1

1

2

Small-scale

0.561

High

774958

FUS
RNA-binding protein FUS

1

20

High-throughput

0.561

High

846576

MSH2
DNA mismatch repair protein Msh2

1

3

Small-scale

0.561

High

959607

TBA1A
Tubulin alpha-1A chain

1

12

High-throughput

0.561

High

959678

DNM3L
DNA

1

3

Small-scale

0.561

High

431533

AP2A
Transcription factor AP-2-alpha

1

4

High-throughput

0.554

High

714813

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.554

High

892535

DNLI3
DNA ligase 3

1

3

High-throughput

0.554

High

904525

MECP2
Methyl-CpG-binding protein 2

1

11

High-throughput

0.554

High

959565

FOXK2
Forkhead box protein K2

1

9

High-throughput

0.554

High

959613

VRK3
Serine/threonine-protein kinase VRK3

1

9

High-throughput

0.554

High

959619

SNIP1
Smad nuclear-interacting protein 1

1

4

Small-scale

0.552

High

959618

BANP
Protein BANP

1

0

High-throughput

0.549

High

639701

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.541

High

959627

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.541

High

959660

PKHA5
Pleckstrin homology domain-containing family A member 5

1

7

High-throughput

0.541

High

959669

TXLNG
Gamma-taxilin

1

13

High-throughput

0.541

High

959674

CLIP2
CAP-Gly domain-containing linker protein 2

1

9

High-throughput

0.541

High

136865

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

5

High-throughput

0.536

High

243585

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.536

High

282228

SAP30
Histone deacetylase complex subunit SAP30

1

3

High-throughput

0.536

High

344908

WIZ
Protein Wiz

1

4

High-throughput

0.536

High

423628

ARGI1
Arginase-1

1

1

High-throughput

0.536

High

588367

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.536

High

628736

TBP
TATA-box-binding protein

1

2

High-throughput

0.536

High

703287

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

20

High-throughput

0.536

High

854808

RECQ1
ATP-dependent DNA helicase Q1

1

13

High-throughput

0.536

High

871912

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

5

High-throughput

0.536

High

959554

SKP1
S-phase kinase-associated protein 1

1

3

High-throughput

0.536

High

959557

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

5

High-throughput

0.536

High

959562

FOXK1
Forkhead box protein K1

1

12

High-throughput

0.536

High

959589

HSPB2
Heat shock protein beta-2

1

4

High-throughput

0.536

High

959593

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.536

High

959597

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

7

High-throughput

0.536

High

959600

WBP2L
Postacrosomal sheath WW domain-binding protein

1

4

High-throughput

0.536

High

959605

FOXR1
Forkhead box protein R1

1

13

High-throughput

0.536

High

959608

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.536

High

959621

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

5

High-throughput

0.536

High

959625

HDAC2
Histone deacetylase 2

1

11

High-throughput

0.536

High

959656

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

7

High-throughput

0.536

High

959658

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.536

High

959663

BRMS1
Breast cancer metastasis-suppressor 1

1

7

High-throughput

0.536

High

959668

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

20

High-throughput

0.536

High

959686

MORC2
ATPase MORC2

1

2

High-throughput

0.536

High

617672

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.530

High

959672

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

High-throughput

0.528

High

959612

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

11

High-throughput

0.521

High

786479

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

13

High-throughput

0.515

High

959550

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

13

High-throughput

0.515

High

959551

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

13

High-throughput

0.515

High

241270

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.515

High

245905

KIF1B
Kinesin-like protein KIF1B

1

7

High-throughput

0.515

High

415474

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.515

High

959684

RNF11
RING finger protein 11

1

5

High-throughput

0.515

High

243920

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

5

Small-scale

0.512

High

842287

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.512

High

880263

RL34
Large ribosomal subunit protein eL34

1

2

High-throughput

0.512

High

959560

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.501

High

959573

ZBT17
Zinc finger and BTB domain-containing protein 17

1

4

Small-scale

0.501

High

959575

SMAD4
Mothers against decapentaplegic homolog 4

1

9

Small-scale

0.501

High

959651

PRD14
PR domain zinc finger protein 14

1

1

Small-scale

0.500

High

253071

PLIN3
Perilipin-3

1

1

High-throughput

0.494

High

959624

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.493

High

301388

WFS1
Wolframin

1

0

High-throughput

0.493

High

649723

SPR1B
Cornifin-B

1

1

High-throughput

0.489

High

959590

CCDC6
Coiled-coil domain-containing protein 6

1

11

High-throughput

0.489

High

959616

TXLNB
Beta-taxilin

1

11

High-throughput

0.489

High

959641

MTEF1
Transcription termination factor 1, mitochondrial

1

2

High-throughput

0.489

High

959646

DHB14
L-fucose dehydrogenase

1

3

High-throughput

0.489

High

959664

CHM1A
Charged multivesicular body protein 1a

1

4

High-throughput

0.489

High

124762

AIP
AH receptor-interacting protein

1

3

High-throughput

0.479

High

172641

XPO1
Exportin-1

1

10

High-throughput

0.479

High

212186

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

5

High-throughput

0.479

High

246511

KDM1A
Lysine-specific histone demethylase 1A

1

11

High-throughput

0.479

High

251552

CCNT1
Cyclin-T1

1

7

Small-scale

0.479

High

283595

SUPT3
Transcription initiation protein SPT3 homolog

1

1

Small-scale

0.479

High

284936

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

20

Small-scale

0.479

High

317322

ACL6B
Actin-like protein 6B

1

11

Small-scale

0.479

High

339702

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

349022

LATS1
Serine/threonine-protein kinase LATS1

1

9

High-throughput

0.479

High

355180

ACL6A
Actin-like protein 6A

1

11

Small-scale

0.479

High

408016

TBB4A
Tubulin beta-4A chain

1

9

High-throughput

0.479

High

413519

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

429630

JUN
Transcription factor Jun

1

12

High-throughput

0.479

High

461332

HS90A
Heat shock protein HSP 90-alpha

1

10

High-throughput

0.479

High

468235

HS90B
Heat shock protein HSP 90-beta

1

10

High-throughput

0.479

High

541008

PIM1
Serine/threonine-protein kinase pim-1

1

8

Small-scale

0.479

High

552183

ADT3
ADP/ATP translocase 3

1

8

High-throughput

0.479

High

565850

EF2
Elongation factor 2

1

6

High-throughput

0.479

High

606531

CEBPB
CCAAT/enhancer-binding protein beta

1

18

High-throughput

0.479

High

612959

EGR1
Early growth response protein 1

1

7

High-throughput

0.479

High

650674

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

17

High-throughput

0.479

High

675443

TYY1
Transcriptional repressor protein YY1

1

11

Small-scale

0.479

High

702913

DPOD1
DNA polymerase delta catalytic subunit

1

3

High-throughput

0.479

High

717753

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

Small-scale

0.479

High

718096

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

7

Small-scale

0.479

High

906493

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

6

High-throughput

0.479

High

920776

ACLY
ATP-citrate synthase

1

4

High-throughput

0.479

High

933771

DRG2
Developmentally-regulated GTP-binding protein 2

1

6

High-throughput

0.479

High

959552

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

10

Small-scale

0.479

High

959553

H4
Histone H4

1

9

High-throughput

0.479

High

959555

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

10

Small-scale

0.479

High

959564

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

14

Small-scale

0.479

High

959566

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

4

High-throughput

0.479

High

959572

FOXC1
Forkhead box protein C1

1

11

High-throughput

0.479

High

959577

KLF9
Krueppel-like factor 9

1

20

High-throughput

0.479

High

959578

GIT2
ARF GTPase-activating protein GIT2

1

9

High-throughput

0.479

High

959580

TFDP2
Transcription factor Dp-2

1

3

High-throughput

0.479

High

959584

MO4L2
Mortality factor 4-like protein 2

1

5

Small-scale

0.479

High

959585

ZNHI3
Zinc finger HIT domain-containing protein 3

1

1

Small-scale

0.479

High

959588

EZH2
Histone-lysine N-methyltransferase EZH2

1

19

Small-scale

0.479

High

959591

TAF9
Transcription initiation factor TFIID subunit 9

1

4

Small-scale

0.479

High

959594

GRAP1
GRIP1-associated protein 1

1

9

High-throughput

0.479

High

959602

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.479

High

959603

PKN3
Serine/threonine-protein kinase N3

1

5

High-throughput

0.479

High

959610

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

12

Small-scale

0.479

High

959622

CCHCR
Coiled-coil alpha-helical rod protein 1

1

8

High-throughput

0.479

High

959623

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

959629

FBXW7
F-box/WD repeat-containing protein 7

1

16

Small-scale

0.479

High

959631

PF21A
PHD finger protein 21A

1

15

High-throughput

0.479

High

959632

SPDLY
Protein Spindly

1

11

High-throughput

0.479

High

959633

THA11
THAP domain-containing protein 11

1

1

High-throughput

0.479

High

959637

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

6

High-throughput

0.479

High

959640

MPP8
M-phase phosphoprotein 8

1

15

High-throughput

0.479

High

959642

FEV
Protein FEV

1

13

High-throughput

0.479

High

959648

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

959650

NUF2
Kinetochore protein Nuf2

1

7

High-throughput

0.479

High

959659

EAF6
Chromatin modification-related protein MEAF6

1

3

Small-scale

0.479

High

959666

HM20A
High mobility group protein 20A

1

20

High-throughput

0.479

High

959670

MRGBP
MRG/MORF4L-binding protein

1

3

Small-scale

0.479

High

959673

MO4L1
Mortality factor 4-like protein 1

1

5

Small-scale

0.479

High

959677

RABX5
Rab5 GDP/GTP exchange factor

1

3

High-throughput

0.479

High

959680

RCOR1
REST corepressor 1

1

13

High-throughput

0.479

High

959681

HDAC5
Histone deacetylase 5

1

16

High-throughput

0.479

High

959683

RUVB1
RuvB-like 1

1

9

Small-scale

0.479

High

705297

GRN
Progranulin

1

2

High-throughput

0.470

High

954449

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.470

High

128406

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.458

High

217076

MS18B
Protein Mis18-beta

1

0

High-throughput

0.458

High

279326

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

503566

TFPT
TCF3 fusion partner

1

0

High-throughput

0.458

High

959583

Q14901
Myc protein

1

0

Small-scale

0.438

High

320551

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

6

High-throughput

0.437

High

621460

HXK1
Hexokinase-1

1

2

High-throughput

0.437

High

959563

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.437

High

959581

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.437

High

959596

CCD93
Coiled-coil domain-containing protein 93

1

5

High-throughput

0.437

High

959599

TBC9B
TBC1 domain family member 9B

1

5

High-throughput

0.437

High

959601

PHLB3
Pleckstrin homology-like domain family B member 3

1

14

High-throughput

0.437

High

959611

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

6

High-throughput

0.437

High

959620

GOGA5
Golgin subfamily A member 5

1

12

High-throughput

0.437

High

959644

SEPT5
Septin-5

1

3

High-throughput

0.437

High

959665

TUFT1
Tuftelin

1

1

High-throughput

0.437

High

591264

CD44
CD44 antigen

1

1

High-throughput

0.407

High

616735

SDC1
Syndecan-1

1

2

High-throughput

0.407

High

959558

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.407

High

959604

S27A1
Long-chain fatty acid transport protein 1

1

6

High-throughput

0.407

High

959661

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.279

Low

47315

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

85248

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

959598

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.249

Low

959609

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.249

Low

959635

VPS50
Syndetin

1

0

High-throughput

0.249

Low

959662

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

959676

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025