HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: UBP22 (Q9UPT9)
Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)
Gene: USP22

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	28160502, 31511647, 36528490, 30415952, 35140242, 25452129
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 525
+	Hs
		67121 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		UBP27_HUMAN (114-525): 1.15e-133: 396: 82.20
+	Hs
		373648 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		UBP3_HUMAN (38-517): 8.07e-113: 346: 26.13
+	Hs
		373177 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		UBP42_HUMAN (137-520): 1.83e-101: 334: 26.68
+	Hs
		373365 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		UBP36_HUMAN (139-519): 1.12e-99: 326: 24.87
+	Hs
		288328 MYC_HUMAN (1-454): 4.53e-121: 362: 100.00		UBP2_HUMAN (150-518): 1.79e-99: 314: 30.20
+	Hs
		406751 MYCN_HUMAN (12-451): 8.07e-58: 199: 33.40		UBP36_HUMAN (139-519): 1.12e-99: 326: 24.87