Protein: UBP27
Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27)

Gene: UBP27, USP27X
Organism: Homo sapiens
Interactions: 39
UniProt ID: A6NNY8

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

67130

AT7L3
Ataxin-7-like protein 3

5

4

High-throughput

0.925

High

67133

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

2

16

High-throughput

0.789

High

67148

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

13

High-throughput

0.789

High

67123

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.778

High

67140

SH3K1
SH3 domain-containing kinase-binding protein 1

4

10

High-throughput

0.691

High

67118

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

10

High-throughput

0.618

High

67149

KLH20
Kelch-like protein 20

2

3

High-throughput

0.611

High

67114

B2L11
Bcl-2-like protein 11

2

0

Small-scale

0.559

High

67146

ENY2
Transcription and mRNA export factor ENY2

1

3

High-throughput

0.553

High

67122

TACD2
Tumor-associated calcium signal transducer 2

1

1

High-throughput

0.536

High

67142

SGF29
SAGA-associated factor 29

1

3

High-throughput

0.489

High

67147

AT7L1
Ataxin-7-like protein 1

1

11

High-throughput

0.489

High

67113

ATX7
Ataxin-7

1

10

High-throughput

0.479

High

67116

SUPT3
Transcription initiation protein SPT3 homolog

1

3

High-throughput

0.479

High

67117

TADA3
Transcriptional adapter 3

1

3

High-throughput

0.479

High

67119

ST65G
STAGA complex 65 subunit gamma

1

2

High-throughput

0.479

High

67120

KLF8
Krueppel-like factor 8

1

6

High-throughput

0.479

High

67121

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

67124

CCND1
G1/S-specific cyclin-D1

1

7

Small-scale

0.479

High

67125

CCNE1
G1/S-specific cyclin-E1

1

3

Small-scale

0.479

High

67126

BLK
Tyrosine-protein kinase Blk

1

3

High-throughput

0.479

High

67127

TIF1B
Transcription intermediary factor 1-beta

1

19

Small-scale

0.479

High

67128

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

4

Small-scale

0.479

High

67129

CASP8
Caspase-8

1

2

Small-scale

0.479

High

67131

TAF9
Transcription initiation factor TFIID subunit 9

1

5

High-throughput

0.479

High

67134

TAD2B
Transcriptional adapter 2-beta

1

6

High-throughput

0.479

High

67135

DTX1
E3 ubiquitin-protein ligase DTX1

1

2

Small-scale

0.479

High

67138

SP20H
Transcription factor SPT20 homolog

1

2

High-throughput

0.479

High

67139

KAT2B
Histone acetyltransferase KAT2B

1

11

High-throughput

0.479

High

67141

TADA1
Transcriptional adapter 1

1

3

High-throughput

0.479

High

67143

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

4

Small-scale

0.479

High

67145

TAF9B
Transcription initiation factor TFIID subunit 9B

1

5

High-throughput

0.479

High

67150

TRRAP
Transformation/transcription domain-associated protein

1

8

High-throughput

0.479

High

67151

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

3

High-throughput

0.479

High

67137

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

67132

AT7L2
Ataxin-7-like protein 2

1

9

High-throughput

0.437

High

67144

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

67136

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.426

High

67115

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025