HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: BRAF (P15056)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)
Gene: BRAF

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 28806393, 22605333, 11325826, 34017080, 38496616, 20212043, 18332145, 28514442, 31015455, 31980649, 33961781, 36038253, 23153539, 23934108, 20130576, 26466569, 16803888, 20141835, 37045861, 22169110 and 4 others

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Identification Methods affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, solid phase assay
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~C1_1, C1_1~PK_Tyr_Ser-Thr, C1_1~RBD, C1_1~Pkinase, PK_Tyr_Ser-Thr~Pkinase, RBD~RBD
Common GO terms GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
and 13 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 648
Hs

1 766
+ Gg
+ Mm
+ Hs
+ Hs
+ Hs
+ Xl
+ Mm
+ At
+ Hs
+ Hs
+ Mm
+ Hs
+ At
+ Mm
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024