HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 26496610, 10757792, 31980649, 35271311, 32707033, 15485920, 17979178, 16093354, 19058874, 27703006, 9733801, 7527398, 34017080, 34407391, 38496616, 9311917, 20212043, 21336309, 18556463, 15866172 and 8 others

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Identification Methods affinity chromatography technology, pull down, enzymatic study, proximity labelling technology, biochemical, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, surface plasmon resonance, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Pkinase, Pkinase~Pkinase
Common GO terms GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 16 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 648
Hs

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Last updated: 15 Jul 2024