HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: LRC59 (Q96AG4)
Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed]
Gene: LRRC59

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	32707033, 36244648, 37045861
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 307
+	Hs
		375101 RAF1_HUMAN (1-648): 0: 652: 100.00		SHOC2_HUMAN (6-150): 4.89e-18: 86.3: 22.76
+	Hs
		374273 RAF1_HUMAN (1-648): 0: 652: 100.00		RSU1_HUMAN (9-84): 6.37e-12: 66.6: 34.21
+	Hs
		374892 RAF1_HUMAN (1-648): 0: 652: 100.00		LRC40_HUMAN (11-99): 1.33e-09: 60.8: 24.44
+	Hs
		488770 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		LRC59_HUMAN (1-307): 2.82e-54: 180: 100.00
+	At
		95380 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		TDR_ARATH (16-264): 4e-35: 136: 14.68
+	At
		1338951 Q9SNA0_ARATH (1-640): 3.53e-167: 499: 17.59		Y1571_ARATH (40-264): 3.23e-34: 134: 17.90
+	At
		83724 Y5182_ARATH (2-643): 1.52e-168: 506: 16.09		PXC2_ARATH (43-264): 1.21e-27: 114: 15.04
+	At
		95386 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		Q9LR04_ARATH (65-264): 1.5e-23: 102: 13.86
+	At
		95366 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		RGI4_ARATH (2-128): 1.95e-21: 96.4: 24.62
+	At
		95368 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		PXC3_ARATH (83-264): 4.12e-21: 95.7: 9.89
+	At
		1352202 Q9SNA0_ARATH (1-640): 3.53e-167: 499: 17.59		Y1723_ARATH (60-264): 1.41e-24: 105: 12.08
+	At
		85102 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		RGI2_ARATH (2-119): 1.42e-18: 87.9: 24.17
+	At
		95390 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		Y5639_ARATH (85-214): 2.13e-18: 87.7: 16.79
+	At
		187568 RLK6_ARATH (2-643): 5.27e-165: 497: 15.87		PXC3_ARATH (83-264): 4.12e-21: 95.7: 9.89
+	At
		83740 Y5189_ARATH (10-647): 2.85e-163: 492: 17.04		PXC3_ARATH (83-264): 4.12e-21: 95.7: 9.89
+	At
		84420 RLK6_ARATH (2-643): 5.27e-165: 497: 15.87		IMK3_ARATH (112-305): 1.56e-18: 87.9: 11.88
+	At
		84309 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		Y3148_ARATH (119-234): 2.39e-12: 69.6: 8.62
+	At
		83734 Y5189_ARATH (10-647): 2.85e-163: 492: 17.04		IMK3_ARATH (112-305): 1.56e-18: 87.9: 11.88
+	At
		95375 F4I065_ARATH (2-643): 3.97e-172: 515: 17.03		MIK2_ARATH (119-264): 9.09e-09: 58.3: 7.48
+	At
		84330 RLK6_ARATH (2-643): 5.27e-165: 497: 15.87		Y3148_ARATH (119-234): 2.39e-12: 69.6: 8.62