HitPredict

Interactor 1: TGFB1 (P01137)
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Gene: TGFB1

Interactor 2: TGBR3 (Q03167)
Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
Gene: TGFBR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.917

The method score is based on:

Property	Details
Experiments	8106553, 11323414, 10519421, 9312157, 20856203
Identification Methods	affinity chromatography technology, cross-linking study, coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	TGF_beta~Zona_pellucida
Common GO terms	GO:0001837 - epithelial to mesenchymal transition GO:0005114 - type II transforming growth factor beta receptor binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane and 6 others more... GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0009986 - cell surface GO:0010628 - positive regulation of gene expression GO:0050680 - negative regulation of epithelial cell proliferation GO:0055010 - ventricular cardiac muscle tissue morphogenesis GO:0060391 - positive regulation of SMAD protein signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	390
Hs

1	851

Service provided by Combinatics, Japan

Last updated: 11Aug2025