Protein: EGLN
Endoglin (CD antigen CD105)

Gene: EGLN, ENG
Organism: Homo sapiens
Interactions: 234
UniProt ID: P17813

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001570 - vasculogenesis
GO:0001666 - response to hypoxia
GO:0001837 - epithelial to mesenchymal transition

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571090

TGFR1
TGF-beta receptor type-1

6

12

Small-scale

0.738

High

571091

ACVL1
Serine/threonine-protein kinase receptor R3

6

12

Small-scale

0.733

High

571092

TGFR2
TGF-beta receptor type-2

4

12

Small-scale

0.696

High

351246

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

3

8

Small-scale

0.646

High

571241

GDF2
Growth/differentiation factor 2

2

9

Small-scale

0.646

High

571089

ARRB2
Beta-arrestin-2

3

0

Small-scale

0.613

High

571076

EGLN
Endoglin

2

1

Small-scale

0.584

High

571087

AVR2A
Activin receptor type-2A

2

12

Small-scale

0.584

High

571082

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.578

High

571077

LEG3
Galectin-3

1

0

High-throughput

0.571

High

362644

A2GL
Leucine-rich alpha-2-glycoprotein

1

3

Small-scale

0.561

High

172732

ZN185
Zinc finger protein 185

1

1

High-throughput

0.536

High

200160

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

3

High-throughput

0.536

High

536564

HCLS1
Hematopoietic lineage cell-specific protein

1

1

High-throughput

0.536

High

571097

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.536

High

571099

PAXI
Paxillin

1

3

High-throughput

0.536

High

571105

DEST
Destrin

1

1

High-throughput

0.536

High

571108

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.536

High

571141

SMAD1
Mothers against decapentaplegic homolog 1

1

1

High-throughput

0.536

High

571142

IBP7
Insulin-like growth factor-binding protein 7

1

1

High-throughput

0.536

High

571178

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.536

High

571185

ESAM
Endothelial cell-selective adhesion molecule

1

1

High-throughput

0.536

High

571191

S10AG
Protein S100-A16

1

1

High-throughput

0.536

High

571200

SMAD5
Mothers against decapentaplegic homolog 5

1

1

High-throughput

0.536

High

571201

GDF15
Growth/differentiation factor 15

1

9

High-throughput

0.536

High

571207

JAM3
Junctional adhesion molecule C

1

1

High-throughput

0.536

High

403774

ITB1
Integrin beta-1

1

1

Small-scale

0.515

High

443031

ITA5
Integrin alpha-5

1

1

Small-scale

0.515

High

49937

F168B
Myelin-associated neurite-outgrowth inhibitor

1

0

High-throughput

0.513

High

117969

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.513

High

195626

MCES
mRNA cap guanine-N7 methyltransferase

1

0

High-throughput

0.513

High

215102

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.513

High

328488

MBD3
Methyl-CpG-binding domain protein 3

1

0

High-throughput

0.513

High

330227

BCL10
B-cell lymphoma/leukemia 10

1

0

High-throughput

0.513

High

397258

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.513

High

414723

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.513

High

426567

H10
Histone H1.0

1

0

High-throughput

0.513

High

495456

THIO
Thioredoxin

1

0

High-throughput

0.513

High

568944

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

571079

ARF4
ADP-ribosylation factor 4

1

0

High-throughput

0.513

High

571083

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.513

High

571084

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

571088

CCND3
G1/S-specific cyclin-D3

1

0

High-throughput

0.513

High

571095

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.513

High

571096

GLIP1
Glioma pathogenesis-related protein 1

1

0

High-throughput

0.513

High

571098

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.513

High

571107

LYSC
Lysozyme C

1

0

High-throughput

0.513

High

571112

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.513

High

571113

DHSO
Sorbitol dehydrogenase

1

0

High-throughput

0.513

High

571114

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.513

High

571118

CALD1
Caldesmon

1

0

High-throughput

0.513

High

571120

MPPA
Mitochondrial-processing peptidase subunit alpha

1

0

High-throughput

0.513

High

571121

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

0

High-throughput

0.513

High

571134

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.513

High

571140

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

571143

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.513

High

571150

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

571163

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.513

High

571180

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.513

High

571181

FUBP2
Far upstream element-binding protein 2

1

0

High-throughput

0.513

High

571196

ABHEB
Putative protein-lysine deacylase ABHD14B

1

0

High-throughput

0.513

High

571197

NSE2
E3 SUMO-protein ligase NSE2

1

0

High-throughput

0.513

High

571198

MYADM
Myeloid-associated differentiation marker

1

0

High-throughput

0.513

High

571205

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.513

High

571209

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

571213

NELFA
Negative elongation factor A

1

0

High-throughput

0.513

High

571215

PPIP2
Proline-serine-threonine phosphatase-interacting protein 2

1

0

High-throughput

0.513

High

571217

SRA1
Steroid receptor RNA activator 1

1

0

High-throughput

0.513

High

571218

CHM1A
Charged multivesicular body protein 1a

1

0

High-throughput

0.513

High

571222

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

571225

DJC17
DnaJ homolog subfamily C member 17

1

0

High-throughput

0.513

High

571226

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.513

High

571232

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

0

High-throughput

0.513

High

571237

ZO2
Tight junction protein ZO-2

1

0

High-throughput

0.513

High

571239

EGFL7
Epidermal growth factor-like protein 7

1

0

High-throughput

0.513

High

571242

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

0

High-throughput

0.513

High

571245

RAB21
Ras-related protein Rab-21

1

0

High-throughput

0.513

High

571248

FOXJ3
Forkhead box protein J3

1

0

High-throughput

0.513

High

571139

TRIP6
Thyroid receptor-interacting protein 6

1

3

Small-scale

0.506

High

359642

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.501

High

571128

SRC8
Src substrate cortactin

1

1

High-throughput

0.501

High

147215

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.489

High

209391

PLRG1
Pleiotropic regulator 1

1

2

High-throughput

0.489

High

215314

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

2

High-throughput

0.489

High

280349

GLRX3
Glutaredoxin-3

1

1

High-throughput

0.489

High

299316

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.489

High

571094

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.489

High

571116

LMNB2
Lamin-B2

1

1

High-throughput

0.489

High

571119

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.489

High

571122

TCOF
Treacle protein

1

1

High-throughput

0.489

High

571149

EXOS6
Exosome complex component MTR3

1

1

High-throughput

0.489

High

571187

RNF25
E3 ubiquitin-protein ligase RNF25

1

1

High-throughput

0.489

High

571194

PDLI5
PDZ and LIM domain protein 5

1

3

High-throughput

0.489

High

571203

FSD1
Fibronectin type III and SPRY domain-containing protein 1

1

1

High-throughput

0.489

High

571233

ABI3
ABI gene family member 3

1

2

High-throughput

0.489

High

571234

CRNN
Cornulin

1

1

High-throughput

0.489

High

571259

COMDA
COMM domain-containing protein 10

1

1

High-throughput

0.489

High

571127

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.480

High

571131

KCAB1
Voltage-gated potassium channel subunit beta-1

1

0

High-throughput

0.480

High

571164

HYCC2
Hyccin 2

1

0

High-throughput

0.480

High

571165

SMAP1
Stromal membrane-associated protein 1

1

0

High-throughput

0.480

High

571179

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.480

High

571254

YTHD2
YTH domain-containing family protein 2

1

0

High-throughput

0.480

High

495649

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

1

8

Small-scale

0.479

High

520069

BMP2
Bone morphogenetic protein 2

1

8

Small-scale

0.479

High

571078

BMP7
Bone morphogenetic protein 7

1

8

Small-scale

0.479

High

571115

TGBR3
Transforming growth factor beta receptor type 3

1

1

Small-scale

0.479

High

571117

ACVR1
Activin receptor type-1

1

12

Small-scale

0.479

High

571124

AVR2B
Activin receptor type-2B

1

12

Small-scale

0.479

High

571125

BMPR2
Bone morphogenetic protein receptor type-2

1

12

Small-scale

0.479

High

205017

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

571080

EGR1
Early growth response protein 1

1

0

Small-scale

0.458

High

571144

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

571192

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

571224

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

150516

ABLM1
Actin-binding LIM protein 1

1

3

High-throughput

0.457

High

306568

SCEL
Sciellin

1

1

High-throughput

0.457

High

72525

B4DEF8
Large ribosomal subunit protein mL45

1

1

High-throughput

0.437

High

158151

GIPC1
PDZ domain-containing protein GIPC1

1

1

Small-scale

0.437

High

365

KV228
Immunoglobulin kappa variable 2-28

1

0

High-throughput

0.426

High

371353

ANGI
Angiogenin

1

0

High-throughput

0.426

High

571154

TWF2
Twinfilin-2

1

1

High-throughput

0.407

High

571202

RM45
Large ribosomal subunit protein mL45

1

1

High-throughput

0.407

High

62014

PGP
Glycerol-3-phosphate phosphatase

1

0

High-throughput

0.279

Low

82380

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

0

High-throughput

0.279

Low

150026

IF1AY
Eukaryotic translation initiation factor 1A, Y-chromosomal

1

0

High-throughput

0.279

Low

157292

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.279

Low

169787

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

201563

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

0

High-throughput

0.279

Low

202825

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.279

Low

207705

DENR
Density-regulated protein

1

0

High-throughput

0.279

Low

263165

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.279

Low

311206

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.279

Low

326908

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.279

Low

330632

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.279

Low

396882

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.279

Low

449469

DHPR
Dihydropteridine reductase

1

0

High-throughput

0.279

Low

488564

ARAF
Serine/threonine-protein kinase A-Raf

1

0

High-throughput

0.279

Low

546371

PGAM2
Phosphoglycerate mutase 2

1

0

High-throughput

0.279

Low

571081

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.279

Low

571085

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

1

0

High-throughput

0.279

Low

571086

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

571093

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.279

Low

571100

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.279

Low

571101

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

571102

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

1

0

High-throughput

0.279

Low

571103

TMM33
Transmembrane protein 33

1

0

High-throughput

0.279

Low

571104

SELB
Selenocysteine-specific elongation factor

1

0

High-throughput

0.279

Low

571106

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.279

Low

571109

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.279

Low

571110

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.279

Low

571123

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.279

Low

571126

TF2H2
General transcription factor IIH subunit 2

1

0

High-throughput

0.279

Low

571130

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.279

Low

571132

PTGR1
Prostaglandin reductase 1

1

0

High-throughput

0.279

Low

571133

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.279

Low

571135

EXOS7
Exosome complex component RRP42

1

0

High-throughput

0.279

Low

571136

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.279

Low

571137

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.279

Low

571138

TSN
Translin

1

0

High-throughput

0.279

Low

571145

VP26B
Vacuolar protein sorting-associated protein 26B

1

0

High-throughput

0.279

Low

571146

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.279

Low

571147

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.279

Low

571151

LYPL1
Lysophospholipase-like protein 1

1

0

High-throughput

0.279

Low

571152

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

571153

THOC7
THO complex subunit 7 homolog

1

0

High-throughput

0.279

Low

571155

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.279

Low

571156

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.279

Low

571158

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

571159

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

571160

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.279

Low

571161

TAF8
Transcription initiation factor TFIID subunit 8

1

0

High-throughput

0.279

Low

571162

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.279

Low

571166

MINK1
Misshapen-like kinase 1

1

0

High-throughput

0.279

Low

571167

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.279

Low

571168

LS14A
Protein LSM14 homolog A

1

0

High-throughput

0.279

Low

571169

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

0

High-throughput

0.279

Low

571171

NGDN
Neuroguidin

1

0

High-throughput

0.279

Low

571172

CX038
Uncharacterized protein CXorf38

1

0

High-throughput

0.279

Low

571173

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

0

High-throughput

0.279

Low

571175

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.279

Low

571176

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.279

Low

571177

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.279

Low

571182

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

High-throughput

0.279

Low

571183

CAVN3
Caveolae-associated protein 3

1

0

High-throughput

0.279

Low

571184

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.279

Low

571188

EFHD2
EF-hand domain-containing protein D2

1

0

High-throughput

0.279

Low

571189

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.279

Low

571190

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.279

Low

571193

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.279

Low

571195

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.279

Low

571199

TBCB
Tubulin-folding cofactor B

1

0

High-throughput

0.279

Low

571204

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.279

Low

571208

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.279

Low

571210

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.279

Low

571212

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

0

High-throughput

0.279

Low

571214

PKHF2
Pleckstrin homology domain-containing family F member 2

1

0

High-throughput

0.279

Low

571216

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.279

Low

571219

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.279

Low

571220

BIN3
Bridging integrator 3

1

0

High-throughput

0.279

Low

571221

SAR1A
Small COPII coat GTPase SAR1A

1

0

High-throughput

0.279

Low

571223

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.279

Low

571227

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.279

Low

571228

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

571229

DJB12
DnaJ homolog subfamily B member 12

1

0

High-throughput

0.279

Low

571231

RM15
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.279

Low

571235

COMD3
COMM domain-containing protein 3

1

0

High-throughput

0.279

Low

571236

TRMB
tRNA

1

0

High-throughput

0.279

Low

571238

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.279

Low

571240

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.279

Low

571243

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.279

Low

571244

CNO11
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.279

Low

571246

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.279

Low

571247

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.279

Low

571249

WASF3
Actin-binding protein WASF3

1

0

High-throughput

0.279

Low

571250

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.279

Low

571251

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.279

Low

571252

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.279

Low

571253

RBM7
RNA-binding protein 7

1

0

High-throughput

0.279

Low

571256

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.279

Low

571257

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.279

Low

571258

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.279

Low

571129

CAPR1
Caprin-1

1

0

High-throughput

0.261

Low

571148

PRC2B
Protein PRRC2B

1

0

High-throughput

0.261

Low

571157

WASH2
WAS protein family homolog 2

1

0

High-throughput

0.261

Low

571170

ABCF1
ATP-binding cassette sub-family F member 1

1

0

High-throughput

0.261

Low

571174

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

0

High-throughput

0.261

Low

571186

R51A1
RAD51-associated protein 1

1

0

High-throughput

0.261

Low

571206

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.261

Low

571211

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.261

Low

571230

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.261

Low

571255

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.261

Low

571111

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024