Protein: EGLN
Endoglin (CD antigen CD105)

Gene: EGLN, ENG
Organism: Homo sapiens
Interactions: 241
UniProt ID: P17813

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001570 - vasculogenesis
GO:0001666 - response to hypoxia
GO:0001937 - negative regulation of endothelial cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

608227

TGFR1
TGF-beta receptor type-1

6

12

Small-scale

0.736

High

608228

ACVL1
Activin receptor type-1-like

6

12

Small-scale

0.730

High

608229

TGFR2
TGF-beta receptor type-2

4

12

Small-scale

0.696

High

376698

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

3

8

Small-scale

0.646

High

608380

GDF2
Growth/differentiation factor 2

2

9

Small-scale

0.646

High

608225

ARRB2
Beta-arrestin-2

3

0

Small-scale

0.613

High

608213

LEG3
Galectin-3

1

1

High-throughput

0.596

High

608212

EGLN
Endoglin

2

1

Small-scale

0.584

High

608223

AVR2A
Activin receptor type-2A

2

12

Small-scale

0.584

High

388855

A2GL
Leucine-rich alpha-2-glycoprotein

1

3

Small-scale

0.561

High

183327

ZN185
Zinc finger protein 185

1

1

High-throughput

0.536

High

212708

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

3

High-throughput

0.536

High

571650

HCLS1
Hematopoietic lineage cell-specific protein

1

1

High-throughput

0.536

High

608234

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.536

High

608236

PAXI
Paxillin

1

3

High-throughput

0.536

High

608242

DEST
Destrin

1

1

High-throughput

0.536

High

608245

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.536

High

608278

SMAD1
Mothers against decapentaplegic homolog 1

1

1

High-throughput

0.536

High

608279

IBP7
Insulin-like growth factor-binding protein 7

1

1

High-throughput

0.536

High

608316

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.536

High

608323

ESAM
Endothelial cell-selective adhesion molecule

1

1

High-throughput

0.536

High

608329

S10AG
Protein S100-A16

1

1

High-throughput

0.536

High

608339

SMAD5
Mothers against decapentaplegic homolog 5

1

1

High-throughput

0.536

High

608340

GDF15
Growth/differentiation factor 15

1

9

High-throughput

0.536

High

608346

JAM3
Junctional adhesion molecule C

1

2

High-throughput

0.536

High

431697

ITB1
Integrin beta-1

1

1

Small-scale

0.515

High

473653

ITA5
Integrin alpha-5

1

1

Small-scale

0.515

High

50318

F168B
Myelin-associated neurite-outgrowth inhibitor

1

0

High-throughput

0.513

High

123988

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.513

High

207734

MCES
mRNA cap guanine-N(7) methyltransferase

1

0

High-throughput

0.513

High

228438

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.513

High

352068

MBD3
Methyl-CpG-binding domain protein 3

1

0

High-throughput

0.513

High

424759

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.513

High

443164

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.513

High

455691

H10
Histone H1.0

1

0

High-throughput

0.513

High

528180

THIO
Thioredoxin

1

0

High-throughput

0.513

High

605963

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

608215

ARF4
ADP-ribosylation factor 4

1

0

High-throughput

0.513

High

608219

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.513

High

608220

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

608224

CCND3
G1/S-specific cyclin-D3

1

0

High-throughput

0.513

High

608232

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.513

High

608233

GLIP1
Glioma pathogenesis-related protein 1

1

0

High-throughput

0.513

High

608235

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.513

High

608244

LYSC
Lysozyme C

1

0

High-throughput

0.513

High

608249

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.513

High

608250

DHSO
Sorbitol dehydrogenase

1

0

High-throughput

0.513

High

608251

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.513

High

608255

CALD1
Caldesmon

1

0

High-throughput

0.513

High

608257

MPPA
Mitochondrial-processing peptidase subunit alpha

1

0

High-throughput

0.513

High

608258

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

0

High-throughput

0.513

High

608271

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.513

High

608277

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

608280

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.513

High

608287

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

608300

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.513

High

608318

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.513

High

608334

ABHEB
Putative protein-lysine deacylase ABHD14B

1

0

High-throughput

0.513

High

608335

NSE2
E3 SUMO-protein ligase NSE2

1

0

High-throughput

0.513

High

608336

MYADM
Myeloid-associated differentiation marker

1

0

High-throughput

0.513

High

608344

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.513

High

608348

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

608352

NELFA
Negative elongation factor A

1

0

High-throughput

0.513

High

608356

SRA1
Steroid receptor RNA activator 1

1

0

High-throughput

0.513

High

608357

CHM1A
Charged multivesicular body protein 1a

1

0

High-throughput

0.513

High

608361

PRDC1
Phosphoribosyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

608364

DJC17
DnaJ homolog subfamily C member 17

1

0

High-throughput

0.513

High

608365

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.513

High

608371

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

0

High-throughput

0.513

High

608376

ZO2
Tight junction protein 2

1

0

High-throughput

0.513

High

608378

EGFL7
Epidermal growth factor-like protein 7

1

0

High-throughput

0.513

High

608381

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

0

High-throughput

0.513

High

608384

RAB21
Ras-related protein Rab-21

1

0

High-throughput

0.513

High

608388

FOXJ3
Forkhead box protein J3

1

0

High-throughput

0.513

High

608276

TRIP6
Thyroid receptor-interacting protein 6

1

3

Small-scale

0.506

High

159143

ABLM1
Actin-binding LIM protein 1

1

3

High-throughput

0.501

High

608265

SRC8
Src substrate cortactin

1

1

High-throughput

0.501

High

155727

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.489

High

222434

PLRG1
Pleiotropic regulator 1

1

2

High-throughput

0.489

High

228678

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

2

High-throughput

0.489

High

300103

GLRX3
Glutaredoxin-3

1

1

High-throughput

0.489

High

320621

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.489

High

608231

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.489

High

608253

LMNB2
Lamin-B2

1

1

High-throughput

0.489

High

608256

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.489

High

608286

EXOS6
Exosome complex component MTR3

1

1

High-throughput

0.489

High

608325

RNF25
E3 ubiquitin-protein ligase RNF25

1

1

High-throughput

0.489

High

608332

PDLI5
PDZ and LIM domain protein 5

1

3

High-throughput

0.489

High

608342

FSD1
Fibronectin type III and SPRY domain-containing protein 1

1

1

High-throughput

0.489

High

608360

SAR1A
Small COPII coat GTPase SAR1A

1

1

High-throughput

0.489

High

608372

ABI3
ABI gene family member 3

1

2

High-throughput

0.489

High

608373

CRNN
Cornulin

1

1

High-throughput

0.489

High

608399

COMDA
COMM domain-containing protein 10

1

1

High-throughput

0.489

High

608264

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.480

High

608268

KCAB1
Voltage-gated potassium channel subunit beta-1

1

0

High-throughput

0.480

High

608301

HYCC2
Hyccin 2

1

0

High-throughput

0.480

High

608302

SMAP1
Stromal membrane-associated protein 1

1

0

High-throughput

0.480

High

608317

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.480

High

608394

YTHD2
YTH domain-containing family protein 2

1

0

High-throughput

0.480

High

362730

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

410599

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.479

High

528386

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

1

8

Small-scale

0.479

High

554123

BMP2
Bone morphogenetic protein 2

1

8

Small-scale

0.479

High

608214

BMP7
Bone morphogenetic protein 7

1

8

Small-scale

0.479

High

608252

TGBR3
Transforming growth factor beta receptor type 3

1

1

Small-scale

0.479

High

608254

ACVR1
Activin receptor type-1

1

12

Small-scale

0.479

High

608261

AVR2B
Activin receptor type-2B

1

12

Small-scale

0.479

High

608262

BMPR2
Bone morphogenetic protein receptor type-2

1

12

Small-scale

0.479

High

217804

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

608216

EGR1
Early growth response protein 1

1

0

Small-scale

0.458

High

608226

BASI
Basigin

1

0

High-throughput

0.458

High

608281

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

608330

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

608363

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

328422

SCEL
Sciellin

1

1

High-throughput

0.457

High

385438

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.457

High

480690

LEG1
Galectin-1

1

1

High-throughput

0.445

High

608386

FZD10
Frizzled-10

1

1

High-throughput

0.445

High

75906

B4DEF8
Large ribosomal subunit protein mL45

1

1

High-throughput

0.437

High

167567

GIPC1
PDZ domain-containing protein GIPC1

1

1

Small-scale

0.437

High

365

KV228
Immunoglobulin kappa variable 2-28

1

0

High-throughput

0.426

High

397890

ANGI
Angiogenin

1

0

High-throughput

0.426

High

608338

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.426

High

608291

TWF2
Twinfilin-2

1

1

High-throughput

0.407

High

608341

RM45
Large ribosomal subunit protein mL45

1

1

High-throughput

0.407

High

608218

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.315

High

64704

PGP
Glycerol-3-phosphate phosphatase

1

0

High-throughput

0.279

Low

85951

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

0

High-throughput

0.279

Low

158615

IF1AY
Eukaryotic translation initiation factor 1A, Y-chromosomal

1

0

High-throughput

0.279

Low

166619

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.279

Low

180227

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

214171

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

0

High-throughput

0.279

Low

215497

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.279

Low

220674

DENR
Density-regulated protein

1

0

High-throughput

0.279

Low

280119

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.279

Low

333625

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.279

Low

350277

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.279

Low

353841

BCL10
B-cell lymphoma/leukemia 10

1

0

High-throughput

0.279

Low

354293

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.279

Low

424350

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.279

Low

481019

DHPR
Dihydropteridine reductase

1

0

High-throughput

0.279

Low

521193

ARAF
Serine/threonine-protein kinase A-Raf

1

0

High-throughput

0.279

Low

582068

PGAM2
Phosphoglycerate mutase 2

1

0

High-throughput

0.279

Low

608217

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.279

Low

608221

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.279

Low

608222

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

608230

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.279

Low

608237

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.279

Low

608238

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

608239

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

1

0

High-throughput

0.279

Low

608240

TMM33
Transmembrane protein 33

1

0

High-throughput

0.279

Low

608241

SELB
Selenocysteine-specific elongation factor

1

0

High-throughput

0.279

Low

608243

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.279

Low

608246

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.279

Low

608247

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.279

Low

608259

TCOF
Treacle protein

1

0

High-throughput

0.279

Low

608260

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.279

Low

608263

TF2H2
General transcription factor IIH subunit 2

1

0

High-throughput

0.279

Low

608267

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.279

Low

608269

PTGR1
Prostaglandin reductase 1

1

0

High-throughput

0.279

Low

608270

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.279

Low

608272

EXOS7
Exosome complex component RRP42

1

0

High-throughput

0.279

Low

608273

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.279

Low

608274

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.279

Low

608275

TSN
Translin

1

0

High-throughput

0.279

Low

608282

VP26B
Vacuolar protein sorting-associated protein 26B

1

0

High-throughput

0.279

Low

608283

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.279

Low

608284

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.279

Low

608288

LYPL1
Lysophospholipase-like protein 1

1

0

High-throughput

0.279

Low

608289

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

608290

THOC7
THO complex subunit 7

1

0

High-throughput

0.279

Low

608292

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.279

Low

608293

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.279

Low

608295

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

608296

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

608297

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.279

Low

608298

TAF8
Transcription initiation factor TFIID subunit 8

1

0

High-throughput

0.279

Low

608299

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.279

Low

608303

MINK1
Misshapen-like kinase 1

1

0

High-throughput

0.279

Low

608305

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.279

Low

608306

LS14A
Protein LSM14 homolog A

1

0

High-throughput

0.279

Low

608307

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

0

High-throughput

0.279

Low

608309

NGDN
Neuroguidin

1

0

High-throughput

0.279

Low

608310

CX038
Uncharacterized protein CXorf38

1

0

High-throughput

0.279

Low

608311

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

0

High-throughput

0.279

Low

608313

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.279

Low

608314

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.279

Low

608315

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.279

Low

608319

FUBP2
Far upstream element-binding protein 2

1

0

High-throughput

0.279

Low

608320

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

High-throughput

0.279

Low

608321

CAVN3
Caveolae-associated protein 3

1

0

High-throughput

0.279

Low

608322

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.279

Low

608326

EFHD2
EF-hand domain-containing protein D2

1

0

High-throughput

0.279

Low

608327

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.279

Low

608328

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.279

Low

608331

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.279

Low

608333

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.279

Low

608337

TBCB
Tubulin-folding cofactor B

1

0

High-throughput

0.279

Low

608343

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.279

Low

608347

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.279

Low

608349

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.279

Low

608351

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

0

High-throughput

0.279

Low

608353

PKHF2
Pleckstrin homology domain-containing family F member 2

1

0

High-throughput

0.279

Low

608354

PPIP2
Proline-serine-threonine phosphatase-interacting protein 2

1

0

High-throughput

0.279

Low

608355

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.279

Low

608358

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.279

Low

608359

BIN3
Bridging integrator 3

1

0

High-throughput

0.279

Low

608362

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.279

Low

608366

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.279

Low

608367

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

608368

DJB12
DnaJ homolog subfamily B member 12

1

0

High-throughput

0.279

Low

608370

RM15
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.279

Low

608374

COMD3
COMM domain-containing protein 3

1

0

High-throughput

0.279

Low

608375

TRMB
tRNA

1

0

High-throughput

0.279

Low

608377

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.279

Low

608379

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.279

Low

608382

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.279

Low

608383

CNO11
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.279

Low

608385

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.279

Low

608387

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.279

Low

608389

WASF3
Actin-binding protein WASF3

1

0

High-throughput

0.279

Low

608390

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.279

Low

608391

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.279

Low

608392

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.279

Low

608393

RBM7
RNA-binding protein 7

1

0

High-throughput

0.279

Low

608396

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.279

Low

608397

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.279

Low

608398

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.279

Low

608266

CAPR1
Caprin-1

1

0

High-throughput

0.261

Low

608285

PRC2B
Protein PRRC2B

1

0

High-throughput

0.261

Low

608294

WASH2
WAS protein family homolog 2

1

0

High-throughput

0.261

Low

608308

ABCF1
ATP-binding cassette sub-family F member 1

1

0

High-throughput

0.261

Low

608312

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

0

High-throughput

0.261

Low

608324

R51A1
RAD51-associated protein 1

1

0

High-throughput

0.261

Low

608345

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.261

Low

608350

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.261

Low

608369

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.261

Low

608395

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.261

Low

608248

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.249

Low

608304

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025