Interactor 1: NGF (P01138)
Beta-nerve growth factor (Beta-NGF)
Gene: NGF
Interactor 2: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 0.60 | 0.753 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 10490030, 14985763, 11729324, 11738045, 10713102, 9857023, 9083066, 1849459 |
| Identification Methods | x-ray crystallography, pull down, biochemical, molecular sieving, cross-linking study, surface plasmon resonance |
| Interaction Type | association, direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0007623 - circadian rhythm GO:0008285 - negative regulation of cell population proliferation GO:0010976 - positive regulation of neuron projection development GO:0030424 - axon and 8 others more... |
| Homologous interactions | 9 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
