HitPredict

Interactor 1: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27545878
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 639
+	Hs
		377913 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33
+	Hs
		377925 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		K2C7_HUMAN (86-542): 4.84e-131: 395: 52.62
+	Hs
		377904 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		K2C1_HUMAN (143-509): 1.14e-110: 348: 71.94
+	Hs
		227196 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		KRT86_HUMAN (72-493): 1.23e-87: 283: 48.23
+	Hs
		377940 TNFA_HUMAN (1-233): 1.88e-111: 320: 100.00		K2C5_HUMAN (1-494): 1.41e-80: 267: 61.08