HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: K1C40 (Q6A162)
Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)
Gene: KRT40

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	36949045
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 644 Hs			1 431
+	Hs
		280508 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53
+	Hs
		359290 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C14_HUMAN (87-400): 4.31e-146: 425: 53.82
+	Mm
		1322195 K2C7_MOUSE (138-538): 3.51e-141: 421: 58.35		K1C17_MOUSE (27-401): 5.31e-148: 429: 46.93
+	Hs
		280646 K2C78_HUMAN (119-543): 1.51e-130: 395: 55.09		KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53
+	Hs
		409071 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KT33B_HUMAN (23-429): 5.43e-111: 333: 58.48
+	Hs
		408980 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C19_HUMAN (82-397): 4.55e-103: 313: 51.90
+	Hs
		409054 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C17_HUMAN (82-401): 2.06e-100: 307: 52.81
+	Hs
		408981 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C16_HUMAN (85-412): 2.56e-96: 298: 51.52
+	Hs
		409000 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C15_HUMAN (88-401): 4.65e-95: 295: 52.38
+	Hs
		49549 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		A1A4E9_HUMAN (80-411): 7.5e-95: 294: 50.75
+	Hs
		408990 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C13_HUMAN (80-411): 1.72e-94: 293: 50.75
+	Hs
		444534 K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33		K1C17_HUMAN (82-401): 2.06e-100: 307: 52.81
+	Mm
		444567 K2C7_MOUSE (138-538): 3.51e-141: 421: 58.35		K1C13_MOUSE (84-401): 2.84e-91: 284: 51.10
+	Hs
		409184 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT35_HUMAN (2-427): 4.45e-87: 274: 59.35
+	Hs
		280770 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT36_HUMAN (7-407): 2.14e-84: 267: 63.34
+	Hs
		409072 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1H2_HUMAN (1-426): 1.69e-83: 265: 55.63
+	Hs
		409116 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1C40_HUMAN (1-431): 4.93e-84: 265: 100.00
+	Hs
		280943 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT38_HUMAN (1-430): 8.86e-77: 247: 49.77
+	Hs
		280845 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		KRT37_HUMAN (1-429): 1.93e-75: 243: 48.25
+	Hs
		409082 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		K1H1_HUMAN (48-425): 7.13e-75: 241: 63.23