Protein: HLAE
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]

Gene: HLAE, HLA-E
Organism: Homo sapiens
Interactions: 91
UniProt ID: P13747

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001815 - positive regulation of antibody-dependent cellular cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002250 - adaptive immune response
GO:0002476 - antigen processing and presentation of endogenous peptide antigen via MHC class Ib

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568039

HLAF
HLA class I histocompatibility antigen, alpha chain F

4

16

Small-scale

0.908

High

520732

HLAC
HLA class I histocompatibility antigen, C alpha chain

3

16

High-throughput

0.861

High

568048

EPHB4
Ephrin type-B receptor 4

3

9

High-throughput

0.861

High

568078

HMR1
Major histocompatibility complex class I-related protein 1

3

16

High-throughput

0.861

High

568033

HLAG
HLA class I histocompatibility antigen, alpha chain G

2

16

High-throughput

0.811

High

568083

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

2

3

High-throughput

0.811

High

568050

FCGRN
IgG receptor FcRn large subunit p51

2

17

High-throughput

0.789

High

568059

KLRD1
Natural killer cells antigen CD94

2

20

Small-scale

0.768

High

568051

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

20

Small-scale

0.755

High

409242

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

15

High-throughput

0.737

High

379851

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

15

High-throughput

0.712

High

380216

HLAH
Putative HLA class I histocompatibility antigen, alpha chain H

2

15

High-throughput

0.712

High

567789

PRG2
Bone marrow proteoglycan

1

10

High-throughput

0.691

High

568052

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

18

High-throughput

0.691

High

568065

LRC24
Leucine-rich repeat-containing protein 24

1

5

High-throughput

0.691

High

568076

CLC2B
C-type lectin domain family 2 member B

1

20

High-throughput

0.691

High

568090

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

6

High-throughput

0.691

High

568097

BTNL2
Butyrophilin-like protein 2

1

6

High-throughput

0.691

High

341281

ECEL1
Endothelin-converting enzyme-like 1

3

4

High-throughput

0.667

High

568035

ITA6
Integrin alpha-6

3

1

High-throughput

0.667

High

568043

MA2A2
Alpha-mannosidase 2x

3

1

High-throughput

0.667

High

568044

PLXA3
Plexin-A3

3

7

High-throughput

0.667

High

568060

GAS6
Growth arrest-specific protein 6

3

1

High-throughput

0.667

High

568069

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

3

3

High-throughput

0.667

High

568070

WDFY3
WD repeat and FYVE domain-containing protein 3

3

3

High-throughput

0.667

High

568087

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

3

1

High-throughput

0.667

High

568092

CNTP3
Contactin-associated protein-like 3

3

1

High-throughput

0.667

High

568095

CNNM1
Metal transporter CNNM1

3

3

High-throughput

0.667

High

568057

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

3

0

High-throughput

0.638

High

568058

ASPH
Aspartyl/asparaginyl beta-hydroxylase

3

0

High-throughput

0.638

High

568101

BACE2
Beta-secretase 2

3

0

High-throughput

0.638

High

342731

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.618

High

409555

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

20

High-throughput

0.618

High

410570

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

17

High-throughput

0.618

High

568036

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

20

Small-scale

0.618

High

568037

NKG2C
NKG2-C type II integral membrane protein

1

20

Small-scale

0.618

High

568041

BASI
Basigin

1

4

High-throughput

0.618

High

568034

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

2

1

High-throughput

0.611

High

568046

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

2

2

High-throughput

0.611

High

568045

NEK4
Serine/threonine-protein kinase Nek4

3

3

High-throughput

0.609

High

568080

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

3

1

High-throughput

0.609

High

568081

TECT2
Tectonic-2

3

4

High-throughput

0.609

High

568096

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

3

6

High-throughput

0.609

High

568038

CALR
Calreticulin

2

9

Small-scale

0.595

High

568103

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.585

High

380518

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

20

High-throughput

0.575

High

568063

MICB
MHC class I polypeptide-related sequence B

1

16

High-throughput

0.575

High

568082

PP16A
Protein phosphatase 1 regulatory subunit 16A

1

0

High-throughput

0.560

High

568049

PAR2
Proteinase-activated receptor 2

1

3

High-throughput

0.541

High

547958

PSPC
Surfactant protein C

1

4

High-throughput

0.536

High

563102

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

568032

PERF
Perforin-1

1

1

High-throughput

0.536

High

568054

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

18

High-throughput

0.536

High

568067

BRID5
BRICHOS domain-containing protein 5

1

4

High-throughput

0.536

High

568079

T106A
Transmembrane protein 106A

1

5

High-throughput

0.536

High

568085

SORT
Sortilin

1

1

High-throughput

0.536

High

568093

SEM6B
Semaphorin-6B

1

2

High-throughput

0.536

High

568098

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

12

High-throughput

0.536

High

568055

TAP2
Antigen peptide transporter 2

1

9

Small-scale

0.515

High

568094

UD17
UDP-glucuronosyltransferase 1A7

1

5

High-throughput

0.489

High

568100

DJC16
DnaJ homolog subfamily C member 16

1

9

High-throughput

0.489

High

175315

PLXB2
Plexin-B2

1

8

High-throughput

0.479

High

217773

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

539768

RALA
Ras-related protein Ral-A

1

11

High-throughput

0.479

High

568040

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

568047

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

2

High-throughput

0.479

High

568084

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

568086

ABCA3
Phospholipid-transporting ATPase ABCA3

1

4

High-throughput

0.479

High

568089

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.479

High

568102

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

6

High-throughput

0.479

High

568062

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

0

High-throughput

0.458

High

568075

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.458

High

568042

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.445

High

568056

SLC31
Amino acid transporter heavy chain SLC3A1

1

4

High-throughput

0.445

High

568064

S39AC
Zinc transporter ZIP12

1

13

High-throughput

0.445

High

568068

S39A5
Zinc transporter ZIP5

1

13

High-throughput

0.445

High

568072

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

568073

S22A8
Organic anion transporter 3

1

2

High-throughput

0.445

High

568088

S39A3
Zinc transporter ZIP3

1

13

High-throughput

0.445

High

515672

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.439

High

568077

TM131
Transmembrane protein 131

1

4

High-throughput

0.437

High

515617

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.417

High

170643

CLGN
Calmegin

1

9

High-throughput

0.407

High

568066

NTCP5
Sodium/bile acid cotransporter 5

1

1

High-throughput

0.407

High

568071

EFNMT
eEF1A lysine and N-terminal methyltransferase

3

0

High-throughput

0.347

High

67353

RTL8C
Retrotransposon Gag-like protein 8C

2

0

High-throughput

0.318

High

568074

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

2

0

High-throughput

0.318

High

568061

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.279

Low

568053

EREP3
Protein ENTREP3

1

0

High-throughput

0.249

Low

568091

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.249

Low

568099

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025