HitPredict

Interactor 1: S100B (P04271)
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Gene: S100B

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 1342
+	Hs
		601812 S10A4_HUMAN (3-90): 2.3e-30: 104: 47.73		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		601869 S10AA_HUMAN (2-89): 2.16e-29: 102: 38.64		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		685170 S10AB_HUMAN (2-91): 3e-33: 112: 35.56		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		642945 S10A4_HUMAN (3-90): 2.3e-30: 104: 47.73		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		893799 S10AA_HUMAN (2-89): 2.16e-29: 102: 38.64		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383643 S10AB_HUMAN (2-91): 3e-33: 112: 35.56		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		338660 HORN_HUMAN (1-92): 1.99e-34: 125: 30.44		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338011 S10AB_HUMAN (2-91): 3e-33: 112: 35.56		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		383930 S10AG_HUMAN (2-92): 8.88e-23: 85.6: 28.26		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337962 S10A4_HUMAN (3-90): 2.3e-30: 104: 47.73		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		383989 S10AE_HUMAN (2-83): 1.74e-19: 77.5: 29.27		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337773 S10A9_HUMAN (1-91): 3.59e-29: 102: 36.96		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338220 S10AA_HUMAN (2-89): 2.16e-29: 102: 38.64		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		416337 S10A9_HUMAN (1-91): 3.59e-29: 102: 36.96		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		396674 S10A8_HUMAN (1-92): 4.18e-25: 91.4: 32.61		INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51