Protein: HBA
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin]

Gene: HBA, HBA1;
Organism: Homo sapiens
Interactions: 170
UniProt ID: P69905

Gene Ontology (top 5):
GO:0005344 - oxygen carrier activity
GO:0005506 - iron ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

999337

HBB
Hemoglobin subunit beta

15

18

Small-scale

0.984

High

999671

IGSF8
Immunoglobulin superfamily member 8

3

2

High-throughput

0.861

High

380815

HBE
Hemoglobin subunit epsilon

3

18

Small-scale

0.849

High

999613

HBG2
Hemoglobin subunit gamma-2

3

18

Small-scale

0.849

High

999694

AHSP
Alpha-hemoglobin-stabilizing protein

3

0

Small-scale

0.792

High

380748

HBD
Hemoglobin subunit delta

2

18

High-throughput

0.783

High

479185

HBAT
Hemoglobin subunit theta-1

2

16

High-throughput

0.783

High

359967

NB5R3
NADH-cytochrome b5 reductase 3

1

3

Small-scale

0.724

High

713081

NOS3
Nitric oxide synthase 3

1

1

Small-scale

0.724

High

210741

KLK10
Kallikrein-10

1

3

High-throughput

0.691

High

635657

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

3

1

High-throughput

0.667

High

999665

GDPD1
Lysophospholipase D GDPD1

3

2

High-throughput

0.667

High

999691

PGPI
Pyroglutamyl-peptidase 1

3

1

High-throughput

0.667

High

999628

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.656

High

241367

PRKN
E3 ubiquitin-protein ligase parkin

3

3

High-throughput

0.640

High

327000

NXPH2
Neurexophilin-2

3

0

High-throughput

0.638

High

208125

PLXB1
Plexin-B1

2

2

High-throughput

0.628

High

536947

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.628

High

721473

GSTT1
Glutathione S-transferase theta-1

2

1

High-throughput

0.628

High

749319

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

1

High-throughput

0.628

High

939485

FCGRN
IgG receptor FcRn large subunit p51

2

1

High-throughput

0.628

High

999643

MK06
Mitogen-activated protein kinase 6

2

3

High-throughput

0.628

High

999673

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

1

High-throughput

0.628

High

999682

REN3A
Regulator of nonsense transcripts 3A

2

2

High-throughput

0.628

High

366168

HPT
Haptoglobin

1

2

High-throughput

0.618

High

627515

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

3

High-throughput

0.609

High

999651

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

3

1

High-throughput

0.609

High

300334

KRT34
Keratin, type I cuticular Ha4

2

4

High-throughput

0.606

High

999640

K1H1
Keratin, type I cuticular Ha1

2

4

High-throughput

0.606

High

999685

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

467693

CEL2A
Chymotrypsin-like elastase family member 2A

1

1

High-throughput

0.575

High

553346

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

1

High-throughput

0.574

High

999667

GTR14
Solute carrier family 2, facilitated glucose transporter member 14

2

1

High-throughput

0.574

High

999675

MACD1
ADP-ribose glycohydrolase MACROD1

2

1

High-throughput

0.574

High

999686

MSL2
E3 ubiquitin-protein ligase MSL2

2

1

High-throughput

0.574

High

999655

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.573

High

619731

VCAM1
Vascular cell adhesion protein 1

2

4

High-throughput

0.571

High

999639

ARHG6
Rho guanine nucleotide exchange factor 6

2

2

High-throughput

0.571

High

999702

NUFP1
FMR1-interacting protein NUFIP1

2

1

High-throughput

0.558

High

533636

CLUS
Clusterin

2

0

Small-scale

0.547

High

951605

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.541

High

133017

MATN2
Matrilin-2

1

2

High-throughput

0.536

High

140225

SDCB1
Syntenin-1

1

2

High-throughput

0.536

High

155396

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

1

High-throughput

0.536

High

182505

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

349032

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.536

High

351679

SG1D1
Secretoglobin family 1D member 1

1

2

High-throughput

0.536

High

387259

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.536

High

449704

H2B1J
Histone H2B type 1-J

1

1

High-throughput

0.536

High

472395

FGF4
Fibroblast growth factor 4

1

2

High-throughput

0.536

High

479207

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

2

High-throughput

0.536

High

727762

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.536

High

787976

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

853984

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

985434

RL32
Large ribosomal subunit protein eL32

1

2

High-throughput

0.536

High

999634

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

1

High-throughput

0.536

High

999648

FBLN7
Fibulin-7

1

1

High-throughput

0.536

High

999656

ARMD1
Armadillo-like helical domain containing protein 1

1

1

High-throughput

0.536

High

999659

PXK
PX domain-containing protein kinase-like protein

1

3

High-throughput

0.536

High

999666

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

1

High-throughput

0.536

High

999681

CSTL1
Cystatin-like 1

1

6

High-throughput

0.536

High

999687

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.536

High

999698

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.536

High

999703

DKKL1
Dickkopf-like protein 1

1

1

High-throughput

0.536

High

999704

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.536

High

999706

PLLP
Plasmolipin

1

1

High-throughput

0.536

High

999644

CCD57
Coiled-coil domain-containing protein 57

1

4

High-throughput

0.523

High

999641

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.518

High

516991

NT2NC
Notch homolog 2 N-terminal-like protein C

1

3

High-throughput

0.515

High

262217

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.514

High

250543

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

485934

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.513

High

532169

CD28
T-cell-specific surface glycoprotein CD28

1

0

High-throughput

0.513

High

736914

GBP2
Guanylate-binding protein 2

1

0

High-throughput

0.513

High

764648

CTNB1
Catenin beta-1

1

0

High-throughput

0.513

High

847774

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.513

High

999638

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

999647

KLH22
Kelch-like protein 22

1

0

High-throughput

0.513

High

999657

UD2A3
UDP-glucuronosyltransferase 2A3

1

0

High-throughput

0.513

High

999683

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.513

High

999693

STMN3
Stathmin-3

1

0

High-throughput

0.513

High

999696

OPT
Opticin

1

0

High-throughput

0.513

High

384654

CRYAB
Alpha-crystallin B chain

1

2

Small-scale

0.501

High

999709

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

999632

MERTK
Tyrosine-protein kinase Mer

1

5

High-throughput

0.500

High

184156

RER1
Protein RER1

1

1

High-throughput

0.489

High

194464

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

851054

LPAR6
Lysophosphatidic acid receptor 6

1

1

High-throughput

0.489

High

999642

TAF12
Transcription initiation factor TFIID subunit 12

1

1

High-throughput

0.489

High

999653

C1QL3
Complement C1q-like protein 3

1

1

High-throughput

0.489

High

999664

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

1

High-throughput

0.489

High

999672

CI085
Uncharacterized protein C9orf85

1

1

High-throughput

0.489

High

999674

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.489

High

999688

RIC8A
Chaperone Ric-8A

1

1

High-throughput

0.489

High

999705

T3JAM
TRAF3-interacting JNK-activating modulator

1

3

High-throughput

0.489

High

999629

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.486

High

999658

NT2NA
Notch homolog 2 N-terminal-like protein A

1

3

High-throughput

0.481

High

999684

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.480

High

302476

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

High-throughput

0.479

High

363120

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

389274

FINC
Fibronectin

1

1

High-throughput

0.479

High

390010

ALBU
Albumin

1

1

High-throughput

0.479

High

400638

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

565340

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

641563

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

8

High-throughput

0.479

High

947160

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.479

High

970309

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

986330

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

999631

FOXO1
Forkhead box protein O1

1

3

High-throughput

0.479

High

999637

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

999645

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

999652

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

999654

FBW10
F-box/WD repeat-containing protein 10

1

1

High-throughput

0.479

High

999661

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

999676

CP250
Centrosome-associated protein CEP250

1

3

High-throughput

0.479

High

999677

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

999689

ANLN
Anillin

1

1

High-throughput

0.479

High

999690

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.479

High

999697

HDAC6
Protein deacetylase HDAC6

1

4

Small-scale

0.479

High

999700

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

999701

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.479

High

999708

TRAF6
TNF receptor-associated factor 6

1

6

Small-scale

0.479

High

522259

OSTP
Osteopontin

1

0

Small-scale

0.460

High

945748

ISK7
Serine protease inhibitor Kazal-type 7

1

0

Small-scale

0.460

High

999699

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.460

High

272067

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

380000

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

388395

B3AT
Band 3 anion transport protein

1

0

Small-scale

0.458

High

583280

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

590869

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

681333

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

872185

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

999636

CUL7
Cullin-7

1

0

High-throughput

0.458

High

999678

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

936712

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.457

High

999669

TSC1
Hamartin

1

4

Small-scale

0.457

High

329833

SNX4
Sorting nexin-4

1

1

High-throughput

0.445

High

456219

CATD
Cathepsin D

1

1

Small-scale

0.445

High

529602

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

607918

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

1

High-throughput

0.445

High

999630

MFGM
Lactadherin

1

1

High-throughput

0.445

High

999649

NTCP5
Sodium/bile acid cotransporter 5

1

1

High-throughput

0.445

High

506

NBPFJ
NBPF family member NBPF19

1

3

High-throughput

0.439

High

999695

RN181
E3 ubiquitin-protein ligase RNF181

1

3

Small-scale

0.439

High

711091

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

Small-scale

0.438

High

105737

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

277287

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

293543

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

371727

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

670071

NFYB
Nuclear transcription factor Y subunit beta

1

1

Small-scale

0.437

High

878946

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

937704

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.437

High

999633

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.437

High

999662

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.437

High

999663

RHG24
Rho GTPase-activating protein 24

1

5

High-throughput

0.437

High

999668

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

2

High-throughput

0.437

High

999670

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

999679

ASXL3
Putative Polycomb group protein ASXL3

1

5

High-throughput

0.437

High

999680

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

999692

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

999635

LRC32
Transforming growth factor beta activator LRRC32

1

0

High-throughput

0.426

High

346629

TTC4
Tetratricopeptide repeat protein 4

1

1

High-throughput

0.407

High

583529

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.407

High

622148

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

1

High-throughput

0.407

High

999646

S39AC
Zinc transporter ZIP12

1

3

High-throughput

0.407

High

999707

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.407

High

275453

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

2

0

High-throughput

0.328

High

999660

TSN33
Tetraspanin-33

1

0

High-throughput

0.279

Low

324772

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

999650

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025