Interactor 1: VWF (P04275)
von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]
Gene: VWF

Interactor 2: ATS13 (Q76LX8)
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease)
Gene: ADAMTS13

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.913

The method score is based on:

Property Details
Experiments 18492805, 18577516, 16221672, 25512528
Identification Methods protease assay, bio-layer interferometry, surface plasmon resonance
Interaction Type direct interaction, protein cleavage

The annotation score is based on:

Property Details
Interacting Pfam domains TSP_1~VWA
Common GO terms GO:0005178 - integrin binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0007596 - blood coagulation
GO:0030168 - platelet activation
and 1 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 2813
Hs

1 1427
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024