Protein: NEDD4
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)

Gene: NEDD4
Organism: Mus musculus
Interactions: 58
UniProt ID: P46935

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0002250 - adaptive immune response
GO:0003151 - outflow tract morphogenesis
GO:0003197 - endocardial cushion development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

808352

GRB10
Growth factor receptor-bound protein 10

2

16

Small-scale

0.843

High

808368

NFIP1
NEDD4 family-interacting protein 1

4

17

Small-scale

0.694

High

808356

SCNNA
Amiloride-sensitive sodium channel subunit alpha

3

20

Small-scale

0.651

High

808382

SCNNB
Amiloride-sensitive sodium channel subunit beta

3

20

Small-scale

0.651

High

808342

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

14

Small-scale

0.647

High

808345

TNIK
Traf2 and NCK-interacting protein kinase

2

20

Small-scale

0.611

High

808383

SCNNG
Amiloride-sensitive sodium channel subunit gamma

2

20

Small-scale

0.602

High

808372

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.584

High

808347

WBP2
WW domain-binding protein 2

1

9

Small-scale

0.561

High

808362

Q6P8P8
Pulmonary surfactant-associated protein C

1

3

Small-scale

0.561

High

808369

TMG2
Transmembrane gamma-carboxyglutamic acid protein 2

1

14

Small-scale

0.561

High

808371

ARBK1
Beta-adrenergic receptor kinase 1

1

13

Small-scale

0.561

High

808379

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

1

8

Small-scale

0.561

High

808380

RNF11
RING finger protein 11

1

14

Small-scale

0.561

High

808376

BEAN1
Protein BEAN1

1

0

Small-scale

0.537

High

808350

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

2

High-throughput

0.536

High

808351

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

10

High-throughput

0.536

High

808357

FXR1
RNA-binding protein FXR1

1

8

High-throughput

0.536

High

808375

TSC1
Hamartin

1

6

High-throughput

0.536

High

808355

LAPM5
Lysosomal-associated transmembrane protein 5

1

7

Small-scale

0.527

High

808346

WBP1
WW domain-binding protein 1

1

10

Small-scale

0.512

High

69867

SCN2A
Sodium channel protein type 2 subunit alpha

1

20

Small-scale

0.501

High

292021

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

10

Small-scale

0.501

High

808358

SCN9A
Sodium channel protein type 9 subunit alpha

1

20

Small-scale

0.501

High

808361

N4BP1
NEDD4-binding protein 1

1

2

Small-scale

0.501

High

808363

SCNAA
Sodium channel protein type 10 subunit alpha

1

20

Small-scale

0.501

High

808378

SCN5A
Sodium channel protein type 5 subunit alpha

1

20

Small-scale

0.501

High

808381

SCN8A
Sodium channel protein type 8 subunit alpha

1

20

Small-scale

0.501

High

292379

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

13

Small-scale

0.481

High

222826

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.479

High

590261

PO5F1
POU domain, class 5, transcription factor 1

1

4

High-throughput

0.479

High

610561

CBL
E3 ubiquitin-protein ligase CBL

1

11

Small-scale

0.479

High

618910

IRF8
Interferon regulatory factor 8

1

2

High-throughput

0.479

High

648952

TNR5
Tumor necrosis factor receptor superfamily member 5

1

8

Small-scale

0.479

High

740710

PPARG
Peroxisome proliferator-activated receptor gamma

1

11

Small-scale

0.479

High

761803

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.479

High

808343

1433E
14-3-3 protein epsilon

1

12

Small-scale

0.479

High

808344

DLG3
Disks large homolog 3

1

8

Small-scale

0.479

High

808348

RUNX2
Runt-related transcription factor 2

1

11

Small-scale

0.479

High

808353

NF2L2
Nuclear factor erythroid 2-related factor 2

1

13

Small-scale

0.479

High

808354

TRAF3
TNF receptor-associated factor 3

1

16

Small-scale

0.479

High

808359

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

4

Small-scale

0.479

High

808360

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

808364

FACD2
Fanconi anemia group D2 protein homolog

1

1

High-throughput

0.479

High

808365

RAP2A
Ras-related protein Rap-2a

1

4

Small-scale

0.479

High

808366

Q8BPK8
Agenet-like domain-containing protein

1

8

High-throughput

0.479

High

808370

EED
Polycomb protein EED

1

6

High-throughput

0.479

High

808373

ATAD1
Outer mitochondrial transmembrane helix translocase

1

11

Small-scale

0.479

High

808377

RBCC1
RB1-inducible coiled-coil protein 1

1

6

Small-scale

0.479

High

808384

AICDA
Single-stranded DNA cytosine deaminase

1

2

Small-scale

0.479

High

808374

PMEPA
Protein TMEPAI

1

12

Small-scale

0.470

High

808367

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.458

High

57497

A2APF4
Prostate transmembrane protein, androgen induced 1

1

12

Small-scale

0.457

High

808349

Q3UF73
Ion transport domain-containing protein

1

20

Small-scale

0.457

High

729424

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.445

High

371619

CFAD
Complement factor D

1

3

High-throughput

0.437

High

517593

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.408

High


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Last updated: 15 Jul 2024