Protein: H2B2F
Histone H2B type 2-F (H2B-clustered histone 18)

Gene: H2B2F, H2BC18
Organism: Homo sapiens
Interactions: 191
UniProt ID: Q5QNW6

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

419022

H2A1B
Histone H2A type 1-B/E

3

20

High-throughput

0.839

High

979785

H4
Histone H4

3

20

High-throughput

0.839

High

1162966

H2B2E
Histone H2B type 2-E

3

20

High-throughput

0.839

High

256886

H2B1K
Histone H2B type 1-K

3

20

High-throughput

0.827

High

596141

H12
Histone H1.2

2

20

High-throughput

0.789

High

591681

H2AX
Histone H2AX

2

20

High-throughput

0.776

High

987378

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

20

High-throughput

0.776

High

241912

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

502382

H2A1
Histone H2A type 1

2

20

High-throughput

0.754

High

946795

H2B1D
Histone H2B type 1-D

2

20

High-throughput

0.754

High

980827

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

1162794

H2A2C
Histone H2A type 2-C

2

20

High-throughput

0.754

High

1208866

H2B1H
Histone H2B type 1-H

2

20

High-throughput

0.754

High

1208879

H2B1N
Histone H2B type 1-N

2

20

High-throughput

0.754

High

1208882

H2B1L
Histone H2B type 1-L

2

20

High-throughput

0.754

High

985198

RL10A
Large ribosomal subunit protein uL1

3

2

High-throughput

0.667

High

502012

H2AZ
Histone H2A.Z

1

20

High-throughput

0.665

High

595458

H15
Histone H1.5

1

20

High-throughput

0.665

High

1037189

H11
Histone H1.1

1

20

High-throughput

0.665

High

1208843

H2AV
Histone H2A.V

1

20

High-throughput

0.665

High

1208859

PHF10
PHD finger protein 10

1

20

High-throughput

0.665

High

841378

RBM34
RNA-binding protein 34

2

4

High-throughput

0.628

High

904815

MECP2
Methyl-CpG-binding protein 2

2

15

High-throughput

0.628

High

372230

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.618

High

406260

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.618

High

449730

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.618

High

507223

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

508099

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

521731

H14
Histone H1.4

1

20

High-throughput

0.618

High

634034

H2A1D
Histone H2A type 1-D

1

20

High-throughput

0.618

High

659900

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.618

High

754869

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

888117

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.618

High

943365

H2BFS
Histone H2B type F-S

1

19

High-throughput

0.618

High

987063

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.618

High

998407

H31
Histone H3.1

1

20

High-throughput

0.618

High

1208836

USF3
Basic helix-loop-helix domain-containing protein USF3

1

4

High-throughput

0.618

High

1208837

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.618

High

1208845

H2A3
Histone H2A type 3

1

20

High-throughput

0.618

High

1208850

H2A2B
Histone H2A type 2-B

1

20

High-throughput

0.618

High

1208854

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.618

High

1208863

KAT6A
Histone acetyltransferase KAT6A

1

20

Small-scale

0.618

High

1208865

H2A1C
Histone H2A type 1-C

1

20

High-throughput

0.618

High

1208867

IGSF8
Immunoglobulin superfamily member 8

1

20

High-throughput

0.618

High

1208868

H2B1A
Histone H2B type 1-A

1

20

High-throughput

0.618

High

1208874

H2A1H
Histone H2A type 1-H

1

20

High-throughput

0.618

High

1208876

IPO9
Importin-9

1

15

High-throughput

0.618

High

1208878

H2A1A
Histone H2A type 1-A

1

20

High-throughput

0.618

High

1208880

H2A1J
Histone H2A type 1-J

1

20

High-throughput

0.618

High

1208881

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.618

High

1208884

H2AJ
Histone H2A.J

1

20

High-throughput

0.618

High

426512

HMGN2
Non-histone chromosomal protein HMG-17

2

20

High-throughput

0.601

High

601713

HMGA1
High mobility group protein HMG-I/HMG-Y

2

15

High-throughput

0.601

High

913337

MSH6
DNA mismatch repair protein Msh6

1

14

High-throughput

0.575

High

249758

DOK2
Docking protein 2

2

8

High-throughput

0.571

High

440106

LCK
Tyrosine-protein kinase Lck

2

6

High-throughput

0.571

High

702354

ELK4
ETS domain-containing protein Elk-4

2

12

High-throughput

0.571

High

987690

GRB2
Growth factor receptor-bound protein 2

2

18

High-throughput

0.571

High

1097146

MK07
Mitogen-activated protein kinase 7

2

11

High-throughput

0.571

High

975732

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.536

High

1099105

SRSF5
Serine/arginine-rich splicing factor 5

1

4

High-throughput

0.536

High

144015

P3C2B
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

1

2

High-throughput

0.515

High

269559

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

15

High-throughput

0.515

High

424415

HMGN1
Non-histone chromosomal protein HMG-14

1

8

High-throughput

0.515

High

675533

TYY1
Transcriptional repressor protein YY1

1

12

High-throughput

0.515

High

959816

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.515

High

1048219

EMX2
Homeobox protein EMX2

1

2

High-throughput

0.515

High

1050443

UBE3A
Ubiquitin-protein ligase E3A

1

9

High-throughput

0.515

High

1125344

FLNC
Filamin-C

1

15

High-throughput

0.515

High

1131957

MVP
Major vault protein

1

4

High-throughput

0.515

High

1179071

RSPO1
R-spondin-1

1

1

High-throughput

0.515

High

1208835

PA24F
Cytosolic phospholipase A2 zeta

1

13

High-throughput

0.515

High

1208838

PRP8
Pre-mRNA-processing-splicing factor 8

1

6

High-throughput

0.515

High

1208842

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

19

High-throughput

0.515

High

1208848

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

3

High-throughput

0.515

High

1208860

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

5

High-throughput

0.515

High

1208861

TITIN
Titin

1

19

High-throughput

0.515

High

1208862

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

1

High-throughput

0.515

High

1208870

ZN653
Zinc finger protein 653

1

4

High-throughput

0.515

High

1208885

SPON2
Spondin-2

1

3

High-throughput

0.515

High

1208892

PDZD7
PDZ domain-containing protein 7

1

4

High-throughput

0.515

High

1208894

SH24A
SH2 domain-containing protein 4A

1

13

High-throughput

0.515

High

1208901

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

6

High-throughput

0.515

High

1208903

GID8
Glucose-induced degradation protein 8 homolog

1

2

High-throughput

0.515

High

1208908

GPTC8
G patch domain-containing protein 8

1

20

High-throughput

0.515

High

1208909

IKZF2
Zinc finger protein Helios

1

4

High-throughput

0.515

High

985700

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

1208873

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

215829

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

0

High-throughput

0.493

High

347080

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.493

High

1208849

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.493

High

1208888

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.493

High

1208905

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.493

High

1208906

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.493

High

137453

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

20

High-throughput

0.479

High

138150

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

13

High-throughput

0.479

High

175703

SR140
U2 snRNP-associated SURP motif-containing protein

1

3

High-throughput

0.479

High

253251

REV3L
DNA polymerase zeta catalytic subunit

1

6

High-throughput

0.479

High

286774

SKAP2
Src kinase-associated phosphoprotein 2

1

6

High-throughput

0.479

High

291933

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

9

High-throughput

0.479

High

319822

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.479

High

324917

HEXI1
Protein HEXIM1

1

14

High-throughput

0.479

High

427902

ICAM1
Intercellular adhesion molecule 1

1

20

High-throughput

0.479

High

542544

TOP2A
DNA topoisomerase 2-alpha

1

15

High-throughput

0.479

High

565404

ITA4
Integrin alpha-4

1

7

High-throughput

0.479

High

571673

HCLS1
Hematopoietic lineage cell-specific protein

1

20

High-throughput

0.479

High

583313

FOLR1
Folate receptor alpha

1

1

High-throughput

0.479

High

615555

NELFE
Negative elongation factor E

1

1

High-throughput

0.479

High

629907

BTF3
Transcription factor BTF3

1

11

High-throughput

0.479

High

660641

IF4B
Eukaryotic translation initiation factor 4B

1

13

High-throughput

0.479

High

755951

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.479

High

775743

CYLC1
Cylicin-1

1

20

High-throughput

0.479

High

830874

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

837654

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.479

High

861190

MAP1B
Microtubule-associated protein 1B

1

20

High-throughput

0.479

High

877488

HSP77
Putative heat shock 70 kDa protein 7

1

2

High-throughput

0.479

High

879170

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

934712

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

948857

CD81
CD81 antigen

1

11

High-throughput

0.479

High

959181

ABCE1
ATP-binding cassette sub-family E member 1

1

6

High-throughput

0.479

High

990311

1433Z
14-3-3 protein zeta/delta

1

12

High-throughput

0.479

High

1008761

RED1
Double-stranded RNA-specific editase 1

1

14

High-throughput

0.479

High

1086536

TROP
Trophinin

1

8

High-throughput

0.479

High

1115241

CUL4B
Cullin-4B

1

10

High-throughput

0.479

High

1141161

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1151419

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

14

High-throughput

0.479

High

1161106

MK06
Mitogen-activated protein kinase 6

1

16

High-throughput

0.479

High

1194136

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

1208834

TEX35
Testis-expressed protein 35

1

12

High-throughput

0.479

High

1208844

MEPCE
7SK snRNA methylphosphate capping enzyme

1

14

High-throughput

0.479

High

1208847

DPPA2
Developmental pluripotency-associated protein 2

1

10

High-throughput

0.479

High

1208853

SMC5
Structural maintenance of chromosomes protein 5

1

16

High-throughput

0.479

High

1208858

SERB1
SERPINE1 mRNA-binding protein 1

1

12

High-throughput

0.479

High

1208864

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

1208875

CI072
Guanine nucleotide exchange factor C9orf72

1

6

High-throughput

0.479

High

1208877

ATAD5
ATPase family AAA domain-containing protein 5

1

20

High-throughput

0.479

High

1208883

RIOK1
Serine/threonine-protein kinase RIO1

1

12

High-throughput

0.479

High

1208887

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

High-throughput

0.479

High

1208889

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

High-throughput

0.479

High

1208890

SPRTN
DNA-dependent metalloprotease SPRTN

1

8

Small-scale

0.479

High

1208895

MYO10
Unconventional myosin-X

1

13

Small-scale

0.479

High

1208898

DUOX2
Dual oxidase 2

1

12

High-throughput

0.479

High

1208900

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

20

High-throughput

0.479

High

1208914

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

1208916

PCLO
Protein piccolo

1

20

High-throughput

0.479

High

72917

FHAD1
Forkhead-associated domain-containing protein 1

1

13

High-throughput

0.470

High

240095

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

1

2

High-throughput

0.470

High

281520

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

1

3

High-throughput

0.470

High

626964

FST
Follistatin

1

1

High-throughput

0.470

High

1206462

PRC2B
Protein PRRC2B

1

20

High-throughput

0.470

High

1208846

OVCH1
Ovochymase-1

1

1

High-throughput

0.470

High

1208851

DYH10
Dynein axonemal heavy chain 10

1

12

High-throughput

0.470

High

1208857

GAR5B
Golgi-associated RAB2 interactor protein 5B

1

20

High-throughput

0.470

High

1208891

CAD19
Cadherin-19

1

12

High-throughput

0.470

High

1208893

MAGIX
PDZ domain-containing protein MAGIX

1

5

High-throughput

0.470

High

1208896

IL1AP
Interleukin-1 receptor accessory protein

1

2

High-throughput

0.470

High

1208902

FAIM1
Fas apoptotic inhibitory molecule 1

1

2

High-throughput

0.470

High

1208907

FRM4A
FERM domain-containing protein 4A

1

2

High-throughput

0.470

High

1208913

DLGP4
Disks large-associated protein 4

1

4

High-throughput

0.470

High

257468

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

1135702

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1208869

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

187097

PPM1G
Protein phosphatase 1G

1

11

High-throughput

0.445

High

271533

ATG13
Autophagy-related protein 13

1

1

High-throughput

0.445

High

1091679

MYO1E
Unconventional myosin-Ie

1

12

High-throughput

0.445

High

1141657

EEA1
Early endosome antigen 1

1

20

High-throughput

0.445

High

1208899

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

2

High-throughput

0.445

High

1208904

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.445

High

1208912

RUVB2
RuvB-like 2

1

15

High-throughput

0.445

High

1208915

MRCKB
Serine/threonine-protein kinase MRCK beta

1

17

High-throughput

0.445

High

293807

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

353378

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

565631

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

3

High-throughput

0.437

High

946242

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

9

High-throughput

0.437

High

1102311

CD5R2
Cyclin-dependent kinase 5 activator 2

1

12

High-throughput

0.437

High

1168511

KNOP1
Lysine-rich nucleolar protein 1

1

8

High-throughput

0.437

High

1208840

ZN474
Zinc finger protein 474

1

10

High-throughput

0.437

High

1208841

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

1208855

RHG24
Rho GTPase-activating protein 24

1

15

High-throughput

0.437

High

1208872

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.437

High

1208910

HECD1
E3 ubiquitin-protein ligase HECTD1

1

9

High-throughput

0.437

High

1208911

TENN
Tenascin-N

1

20

High-throughput

0.437

High

516528

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

1208871

THOC1
THO complex subunit 1

1

0

Small-scale

0.426

High

348137

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.407

High

1208852

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.407

High

1208856

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

1

High-throughput

0.407

High

1179259

CB068
UPF0561 protein C2orf68

1

0

High-throughput

0.269

Low

1208839

GP179
Probable G-protein coupled receptor 179

1

0

High-throughput

0.269

Low

1208886

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.269

Low

1208897

KCNQ5
Potassium voltage-gated channel subfamily KQT member 5

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025