HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 245
+	Hs
		384604 NTRK1_HUMAN (1-796): 0: 621: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		384623 NTRK1_HUMAN (1-796): 0: 621: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		384357 NTRK1_HUMAN (1-796): 0: 621: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		507877 FGFR1_HUMAN (195-794): 0: 545: 26.34		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		384358 NTRK1_HUMAN (1-796): 0: 621: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		909605 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		384689 NTRK1_HUMAN (1-796): 0: 621: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		384598 NTRK1_HUMAN (1-796): 0: 621: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		607896 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		601493 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		601470 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		609187 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	At
		788498 TMK1_ARATH (62-786): 1.64e-147: 458: 20.34		14333_ARATH (3-243): 8e-143: 401: 61.63
+	Hs
		684060 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		435597 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		435542 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		435604 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		435553 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		435554 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		435594 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33