HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: PTN13 (Q12923)
Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)
Gene: PTPN13

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0051896 - regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 2485
+	Hs
		507970 FGFR1_HUMAN (195-794): 0: 545: 26.34		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		384278 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRB_HUMAN (953-2481): 3.7e-135: 473: 14.59
+	Hs
		384164 NTRK1_HUMAN (1-796): 0: 621: 100.00		EPB41_HUMAN (414-1119): 2.11e-118: 400: 16.97
+	Hs
		384743 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRJ_HUMAN (1183-2475): 1.09e-110: 389: 14.37
+	Hs
		384697 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		385554 NTRK1_HUMAN (1-796): 0: 621: 100.00		E41L5_HUMAN (513-1220): 6.79e-115: 385: 16.35
+	Hs
		384378 NTRK1_HUMAN (1-796): 0: 621: 100.00		RADI_HUMAN (574-969): 6.68e-116: 383: 26.94
+	Hs
		384443 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN9_HUMAN (2136-2470): 4.76e-112: 372: 27.04
+	Hs
		384777 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRS_HUMAN (1007-2468): 3.28e-92: 337: 12.77
+	Hs
		384155 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRF_HUMAN (2189-2468): 4.55e-89: 326: 30.38
+	Hs
		507884 FGFR1_HUMAN (195-794): 0: 545: 26.34		MERL_HUMAN (558-1049): 1.41e-117: 388: 23.65
+	Hs
		507959 FGFR1_HUMAN (195-794): 0: 545: 26.34		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		507885 FGFR1_HUMAN (195-794): 0: 545: 26.34		RADI_HUMAN (574-969): 6.68e-116: 383: 26.94
+	Hs
		384127 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRC_HUMAN (2155-2465): 8.58e-71: 265: 24.78
+	Hs
		507980 FGFR1_HUMAN (195-794): 0: 545: 26.34		PTPRS_HUMAN (1007-2468): 3.28e-92: 337: 12.77
+	Hs
		384279 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTPRG_HUMAN (2228-2472): 1.03e-46: 187: 25.87
+	Hs
		384330 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN6_HUMAN (2215-2480): 9.54e-47: 181: 40.48
+	Hs
		384228 NTRK1_HUMAN (1-796): 0: 621: 100.00		PTN1_HUMAN (2229-2465): 2.56e-45: 172: 37.40
+	Hs
		507839 FGFR1_HUMAN (195-794): 0: 545: 26.34		PTN1_HUMAN (2229-2465): 2.56e-45: 172: 37.40
+	Hs
		573718 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		PTN1_HUMAN (2229-2465): 2.56e-45: 172: 37.40