Protein: APC7
Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)

Gene: APC7, ANAPC7
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q9UJX3

Gene Ontology (top 5):
GO:0000792 - heterochromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718652

CDC27
Cell division cycle protein 27 homolog

21

18

Small-scale

0.987

High

1093079

CDC16
Cell division cycle protein 16 homolog

6

19

High-throughput

0.950

High

1387378

APC16
Anaphase-promoting complex subunit 16

6

5

Small-scale

0.938

High

1460720

CDC23
Cell division cycle protein 23 homolog

4

19

High-throughput

0.900

High

1460745

APC5
Anaphase-promoting complex subunit 5

5

12

Small-scale

0.892

High

948604

APC15
Anaphase-promoting complex subunit 15

3

6

Small-scale

0.847

High

1412127

APC13
Anaphase-promoting complex subunit 13

3

5

High-throughput

0.839

High

1460746

APC4
Anaphase-promoting complex subunit 4

11

11

Small-scale

0.754

High

980510

H4
Histone H4

2

5

High-throughput

0.754

High

1086931

CDC20
Cell division cycle protein 20 homolog

13

20

Small-scale

0.754

High

251818

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

7

18

Small-scale

0.741

High

1460749

FZR1
Fizzy-related protein homolog

5

20

Small-scale

0.696

High

857584

NOTC1
Neurogenic locus notch homolog protein 1

1

4

High-throughput

0.691

High

1340919

CDC26
Anaphase-promoting complex subunit CDC26

4

6

High-throughput

0.678

High

1460747

ANC2
Anaphase-promoting complex subunit 2

3

20

Small-scale

0.656

High

186109

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

19

High-throughput

0.647

High

908869

NEK2
Serine/threonine-protein kinase Nek2

3

11

Small-scale

0.633

High

1099811

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

3

8

Small-scale

0.633

High

951895

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

2

Small-scale

0.629

High

1368519

CBP
CREB-binding protein

2

16

Small-scale

0.624

High

1460748

FBX5
F-box only protein 5

2

7

Small-scale

0.624

High

1430909

APC1
Anaphase-promoting complex subunit 1

3

11

Small-scale

0.624

High

316130

RECQ4
ATP-dependent DNA helicase Q4

1

9

High-throughput

0.618

High

1310808

CUL9
Cullin-9

1

6

Small-scale

0.618

High

920345

PLK1
Serine/threonine-protein kinase PLK1

2

10

High-throughput

0.611

High

1364667

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

3

High-throughput

0.611

High

1391837

AURKB
Aurora kinase B

2

6

High-throughput

0.601

High

1435265

MAGIX
PDZ domain-containing protein MAGIX

3

6

High-throughput

0.599

High

508801

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

5

High-throughput

0.595

High

1244447

CP087
UPF0547 protein C16orf87

3

4

High-throughput

0.593

High

220452

RGS14
Regulator of G-protein signaling 14

1

0

High-throughput

0.586

High

243244

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.584

High

485496

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

10

High-throughput

0.584

High

1129778

MDC1
Mediator of DNA damage checkpoint protein 1

2

16

Small-scale

0.584

High

1287024

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

2

6

Small-scale

0.584

High

1459242

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.584

High

1460744

APC7
Anaphase-promoting complex subunit 7

1

18

Small-scale

0.575

High

397176

ESR1
Estrogen receptor

2

15

High-throughput

0.571

High

1384293

SH3K1
SH3 domain-containing kinase-binding protein 1

2

11

High-throughput

0.571

High

1431419

CDT1
DNA replication factor Cdt1

1

1

Small-scale

0.561

High

415923

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.541

High

221975

FOXS1
Forkhead box protein S1

1

3

High-throughput

0.536

High

455888

H10
Histone H1.0

1

2

High-throughput

0.536

High

487866

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.536

High

540742

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.536

High

601900

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

872862

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.536

High

1100513

TIF1B
Transcription intermediary factor 1-beta

1

12

High-throughput

0.536

High

1116109

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

1134762

NUMA1
Nuclear mitotic apparatus protein 1

1

3

High-throughput

0.536

High

1144211

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1163272

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.536

High

1370447

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.536

High

1404487

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.536

High

1420518

FOXQ1
Forkhead box protein Q1

1

2

High-throughput

0.536

High

1431074

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

821617

TCPZ
T-complex protein 1 subunit zeta

1

4

High-throughput

0.515

High

1369512

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1162716

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

4

Small-scale

0.501

High

1454468

CFA97
Cilia- and flagella-associated protein 97

1

3

High-throughput

0.489

High

157968

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

170415

AURKA
Aurora kinase A

1

6

High-throughput

0.479

High

173523

XPO1
Exportin-1

1

13

High-throughput

0.479

High

175944

SET1A
Histone-lysine N-methyltransferase SETD1A

1

10

High-throughput

0.479

High

260589

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

261566

B4GT2
Beta-1,4-galactosyltransferase 2

1

2

High-throughput

0.479

High

279534

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

292877

GRAP2
GRB2-related adapter protein 2

1

12

High-throughput

0.479

High

296844

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.479

High

334262

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

3

High-throughput

0.479

High

342359

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

346470

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

388328

GLPA
Glycophorin-A

1

1

High-throughput

0.479

High

419263

H2A1B
Histone H2A type 1-B/E

1

3

High-throughput

0.479

High

589988

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

696813

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

700751

PSA5
Proteasome subunit alpha type-5

1

4

Small-scale

0.479

High

714501

PML
Protein PML

1

12

High-throughput

0.479

High

719045

WEE1
Wee1-like protein kinase

1

11

High-throughput

0.479

High

755022

H2B1B
Histone H2B type 1-B

1

5

High-throughput

0.479

High

769466

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

831616

CCNF
Cyclin-F

1

12

High-throughput

0.479

High

851696

GATA4
Transcription factor GATA-4

1

6

High-throughput

0.479

High

909731

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

13

High-throughput

0.479

High

935264

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

965314

WDR5
WD repeat-containing protein 5

1

7

Small-scale

0.479

High

994413

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

7

Small-scale

0.479

High

998927

H31
Histone H3.1

1

6

High-throughput

0.479

High

1017285

H33
Histone H3.3

1

6

High-throughput

0.479

High

1029167

E2F1
Transcription factor E2F1

1

1

Small-scale

0.479

High

1041805

PPARD
Peroxisome proliferator-activated receptor delta

1

8

High-throughput

0.479

High

1064603

HDHD1
Pseudouridine-5'-phosphatase

1

1

High-throughput

0.479

High

1067813

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1089054

TP53B
TP53-binding protein 1

1

10

High-throughput

0.479

High

1106743

SMAD4
Mothers against decapentaplegic homolog 4

1

5

High-throughput

0.479

High

1107318

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1114607

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1135846

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

1141352

BRD3
Bromodomain-containing protein 3

1

13

High-throughput

0.479

High

1163950

UPP1
Uridine phosphorylase 1

1

1

High-throughput

0.479

High

1207274

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

1

High-throughput

0.479

High

1257161

PAXI1
PAX-interacting protein 1

1

10

High-throughput

0.479

High

1276933

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1279181

RAI1
Retinoic acid-induced protein 1

1

8

High-throughput

0.479

High

1280583

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

9

High-throughput

0.479

High

1329931

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

Small-scale

0.479

High

1335054

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1336877

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

11

Small-scale

0.479

High

1367541

ESR2
Estrogen receptor beta

1

15

High-throughput

0.479

High

1383889

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.479

High

1397540

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1405573

TBX5
T-box transcription factor TBX5

1

2

High-throughput

0.479

High

1407011

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.479

High

1430629

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1433858

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

7

High-throughput

0.479

High

1434768

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.479

High

1435425

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1436820

WDR76
WD repeat-containing protein 76

1

9

High-throughput

0.479

High

1446428

BRD7
Bromodomain-containing protein 7

1

14

High-throughput

0.479

High

1446999

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1448705

LATS2
Serine/threonine-protein kinase LATS2

1

3

Small-scale

0.479

High

1452592

APC11
Anaphase-promoting complex subunit 11

1

11

Small-scale

0.479

High

1453032

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

1460278

XPO7
Exportin-7

1

11

High-throughput

0.479

High

1460750

TRI33
E3 ubiquitin-protein ligase TRIM33

1

12

Small-scale

0.479

High

1460751

PHF8
Histone lysine demethylase PHF8

1

6

Small-scale

0.479

High

1460752

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

571535

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.458

High

1083477

MN1
Transcriptional activator MN1

1

0

Small-scale

0.458

High

1149217

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

1193574

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

1229755

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1403368

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

1057028

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

171614

S27A2
Long-chain fatty acid transport protein 2

1

2

High-throughput

0.445

High

1130510

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

869803

MTR1A
Melatonin receptor type 1A

1

1

High-throughput

0.437

High

1101703

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.437

High

1177120

INF2
Inverted formin-2

1

5

High-throughput

0.437

High

1181558

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

13

High-throughput

0.437

High

1192211

AMZ1
Archaemetzincin-1

1

1

High-throughput

0.437

High

1256018

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

1325855

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

3

High-throughput

0.437

High

1327257

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

1350825

PKHO2
Pleckstrin homology domain-containing family O member 2

1

2

High-throughput

0.437

High

1409912

ZFY21
Zinc finger FYVE domain-containing protein 21

1

2

Small-scale

0.437

High

1434184

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.437

High

1453386

MTCH1
Mitochondrial carrier homolog 1

1

4

High-throughput

0.437

High

1458514

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

1

High-throughput

0.437

High

1460753

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.437

High

887312

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

771088

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

0

High-throughput

0.282

High

1397682

IMP1L
Mitochondrial inner membrane protease subunit 1

1

0

High-throughput

0.279

Low

403077

PDGFA
Platelet-derived growth factor subunit A

1

0

High-throughput

0.249

Low

1164619

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

1194089

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025