HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: WDR6 (Q9NNW5)
tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6)
Gene: WDR6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 1121
+	Hs
		1083901 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		1081614 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		608146 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		601600 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		665435 EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		872494 EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		1088144 DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		411502 INSR_HUMAN (493-777): 3e-68: 248: 42.62		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		968495 ROR2_HUMAN (515-783): 2.79e-66: 239: 43.91		WDR6_HUMAN (1-1121): 0: 745: 100.00
+	Hs
		384626 NTRK1_HUMAN (1-796): 0: 621: 100.00		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		254029 NTRK1_HUMAN (1-796): 0: 621: 100.00		WDR1_HUMAN (538-1119): 1.07e-31: 134: 9.41
+	Hs
		385218 NTRK1_HUMAN (1-796): 0: 621: 100.00		GEMI5_HUMAN (758-1120): 9.39e-16: 85.1: 9.37
+	Hs
		384733 NTRK1_HUMAN (1-796): 0: 621: 100.00		TBL3_HUMAN (12-118): 1.81e-11: 70.5: 7.34
+	Hs
		384696 NTRK1_HUMAN (1-796): 0: 621: 100.00		EMAL5_HUMAN (704-1073): 1.35e-10: 68.2: 10.37
+	Hs
		384596 NTRK1_HUMAN (1-796): 0: 621: 100.00		WDR5_HUMAN (390-646): 7.51e-09: 60.7: 13.53
+	Hs
		435605 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		411353 INSR_HUMAN (493-777): 3e-68: 248: 42.62		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Hs
		929718 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21
+	Rn
		88690 INSR_RAT (493-777): 7.31e-66: 241: 41.95		D3ZQR6_RAT (490-1072): 3.41e-18: 93.2: 9.55
+	Hs
		994668 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		SNR40_HUMAN (200-348): 7.65e-10: 64: 26.58