HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: SGT1 (Q9Y2Z0)
Protein SGT1 homolog (Protein 40-6-3) (Sgt1) (Suppressor of G2 allele of SKP1 homolog)
Gene: SUGT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032991 - protein-containing complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 365
+	Hs
		608205 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		384545 NTRK1_HUMAN (1-796): 0: 621: 100.00		PPP5_HUMAN (9-242): 1.39e-38: 145: 14.71
+	Hs
		609621 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		385527 NTRK1_HUMAN (1-796): 0: 621: 100.00		RPAP3_HUMAN (3-129): 5.92e-27: 114: 14.17
+	Hs
		174540 NTRK1_HUMAN (1-796): 0: 621: 100.00		OGT1_HUMAN (48-303): 5e-18: 87.6: 9.51
+	Hs
		385317 NTRK1_HUMAN (1-796): 0: 621: 100.00		TTC28_HUMAN (7-112): 2.84e-13: 73.3: 26.36
+	Hs
		297020 NTRK1_HUMAN (1-796): 0: 621: 100.00		TOM70_HUMAN (3-221): 1.5e-09: 61.4: 9.29
+	Hs
		507978 FGFR1_HUMAN (195-794): 0: 545: 26.34		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		434317 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		SGT1_HUMAN (1-365): 2.37e-88: 272: 100.00
+	Hs
		1028052 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		434258 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		SGTB_HUMAN (91-296): 3.48e-10: 62.2: 12.14
+	Hs
		435627 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		1028054 DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		411373 INSR_HUMAN (493-777): 3e-68: 248: 42.62		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69
+	Hs
		1028125 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		DNJC3_HUMAN (6-326): 2.67e-25: 108: 15.69