HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14519663
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035861 - site of double-strand break
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 2089
+	Mm
		356841 P53_MOUSE (1-393): 0: 589: 77.35		TP53B_MOUSE (181-1970): 1.84e-92: 337: 10.07
+	Hs
		386628 P53_HUMAN (1-393): 0: 619: 100.00		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		387814 P53_HUMAN (1-393): 0: 619: 100.00		NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36
+	Hs
		386973 P53_HUMAN (1-393): 0: 619: 100.00		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		175864 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		387803 P53_HUMAN (1-393): 0: 619: 100.00		C170B_HUMAN (751-1981): 3.73e-25: 116: 8.69
+	Hs
		387805 P53_HUMAN (1-393): 0: 619: 100.00		PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07
+	Hs
		386546 P53_HUMAN (1-393): 0: 619: 100.00		ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40
+	Hs
		386039 P53_HUMAN (1-393): 0: 619: 100.00		MUC1_HUMAN (762-1525): 1.68e-11: 72: 18.23
+	Hs
		387358 P53_HUMAN (1-393): 0: 619: 100.00		MINT_HUMAN (159-1473): 1.72e-10: 68.9: 10.33
+	Dm
		58920 Q9N6D8_DROME (124-325): 3.11e-77: 245: 24.31		A2VEF9_DROME (913-2046): 1.95e-56: 218: 11.68