Protein: PIGN
GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (GPI-ethanolamine transferase I) (GPI-ETI) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N)

Gene: PIGN
Organism: Homo sapiens
Interactions: 79
UniProt ID: O95427

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006506 - GPI anchor biosynthetic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

336559

SPP2B
Signal peptide peptidase-like 2B

3

4

High-throughput

0.662

High

336525

FPR2
N-formyl peptide receptor 2

2

18

High-throughput

0.628

High

336529

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

9

High-throughput

0.628

High

336530

PI2R
Prostacyclin receptor

2

2

High-throughput

0.628

High

336537

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

1

High-throughput

0.628

High

336568

GPR21
Probable G-protein coupled receptor 21

2

3

High-throughput

0.628

High

336565

TXD15
Thioredoxin domain-containing protein 15

3

1

High-throughput

0.609

High

320419

TM63A
Mechanosensitive cation channel TMEM63A

2

0

High-throughput

0.602

High

336573

YIPF3
Protein YIPF3

2

0

High-throughput

0.602

High

170596

CLGN
Calmegin

2

8

High-throughput

0.601

High

336580

SCN3B
Sodium channel regulatory subunit beta-3

1

2

High-throughput

0.575

High

178879

SCAM2
Secretory carrier-associated membrane protein 2

1

1

High-throughput

0.536

High

226389

SNG2
Synaptogyrin-2

1

1

High-throughput

0.536

High

287837

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.536

High

336519

TSN15
Tetraspanin-15

1

2

High-throughput

0.536

High

336521

FBSP1
F-box/SPRY domain-containing protein 1

1

6

High-throughput

0.536

High

336527

V2R
Vasopressin V2 receptor

1

5

High-throughput

0.536

High

336528

SCN4A
Sodium channel protein type 4 subunit alpha

1

1

High-throughput

0.536

High

336531

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

2

High-throughput

0.536

High

336532

GLR
Glucagon receptor

1

9

High-throughput

0.536

High

336534

CCR6
C-C chemokine receptor type 6

1

14

High-throughput

0.536

High

336536

TBB4B
Tubulin beta-4B chain

1

2

High-throughput

0.536

High

336545

CERS6
Ceramide synthase 6

1

1

High-throughput

0.536

High

336552

CERS5
Ceramide synthase 5

1

1

High-throughput

0.536

High

336555

TM87A
Transmembrane protein 87A

1

3

High-throughput

0.536

High

336562

SPSB4
SPRY domain-containing SOCS box protein 4

1

6

High-throughput

0.536

High

336564

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

2

High-throughput

0.536

High

336566

OPALI
Opalin

1

1

High-throughput

0.536

High

336576

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.536

High

336578

RXFP1
Relaxin receptor 1

1

1

High-throughput

0.536

High

336586

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.536

High

336575

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.515

High

136463

GOLI4
Golgi integral membrane protein 4

1

0

High-throughput

0.513

High

184362

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.513

High

336518

SNP29
Synaptosomal-associated protein 29

1

0

High-throughput

0.513

High

336523

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

0

High-throughput

0.513

High

336524

ERD21
ER lumen protein-retaining receptor 1

1

0

High-throughput

0.513

High

336538

MALL
MAL-like protein

1

0

High-throughput

0.513

High

336543

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

0

High-throughput

0.513

High

336551

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

0

High-throughput

0.513

High

336554

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

0

High-throughput

0.513

High

336556

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.513

High

336560

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.513

High

336569

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.513

High

336570

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.513

High

336572

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.513

High

336574

T126A
Transmembrane protein 126A

1

0

High-throughput

0.513

High

336577

PIGU
GPI-anchor transamidase component PIGU

1

0

High-throughput

0.513

High

336583

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

336584

UST
Uronyl 2-sulfotransferase

1

0

High-throughput

0.513

High

336549

S22A9
Organic anion transporter 7

1

3

High-throughput

0.489

High

217661

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

336563

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

336579

ANLN
Anillin

1

0

High-throughput

0.458

High

255949

S19A2
Thiamine transporter 1

1

2

High-throughput

0.445

High

336520

MOT3
Monocarboxylate transporter 3

1

4

High-throughput

0.445

High

336533

CXCR3
C-X-C chemokine receptor type 3

1

16

High-throughput

0.445

High

336535

CXCR4
C-X-C chemokine receptor type 4

1

18

High-throughput

0.445

High

336539

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

12

High-throughput

0.445

High

336540

S39AE
Metal cation symporter ZIP14

1

9

High-throughput

0.445

High

336542

GP107
Protein GPR107

1

3

High-throughput

0.445

High

336544

MFSD5
Molybdate-anion transporter

1

3

High-throughput

0.445

High

336550

AGRG5
Adhesion G-protein coupled receptor G5

1

5

High-throughput

0.445

High

336558

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

5

High-throughput

0.445

High

336567

SPSB2
SPRY domain-containing SOCS box protein 2

1

6

High-throughput

0.445

High

336522

GPHRB
Golgi pH regulator B

1

1

High-throughput

0.437

High

336546

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

336585

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

85330

GPHRA
Golgi pH regulator A

1

1

High-throughput

0.407

High

336557

ZNT7
Zinc transporter 7

1

5

High-throughput

0.407

High

336548

FJX1
Four-jointed box protein 1

1

0

High-throughput

0.282

High

336526

AOFB
Amine oxidase [flavin-containing] B

1

0

High-throughput

0.279

Low

336541

RABL3
Rab-like protein 3

1

0

High-throughput

0.279

Low

336553

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

336561

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

336571

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.279

Low

336581

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.279

Low

336582

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

336547

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025