HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: MAPK5 (Q8IW41)
MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)
Gene: MAPKAPK5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	19166925, 10978313, 9628874, 21575178
Identification Methods	affinity chromatography technology, enzymatic study, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 473
+	Hs
		1080874 HSPB2_HUMAN (1-181): 2.16e-45: 150: 35.52		MAPK5_HUMAN (1-473): 2.28e-164: 474: 100.00
+	Hs
		388473 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		MAPK3_HUMAN (9-364): 4.78e-120: 357: 41.27
+	Rn
		792264 HSPB1_RAT (1-199): 1.73e-70: 215: 82.76		Q4KLJ9_RAT (105-473): 4.94e-129: 380: 96.75
+	Hs
		388304 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		MAPK2_HUMAN (11-364): 2.53e-116: 348: 42.50
+	Mm
		537696 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		MAPK3_MOUSE (7-364): 1.33e-120: 359: 40.77
+	Mm
		537691 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		MAPK2_MOUSE (11-377): 3.58e-117: 350: 41.02
+	Hs
		388431 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KCC1A_HUMAN (28-311): 4.94e-48: 171: 35.50
+	Hs
		270358 CRYAA_HUMAN (21-195): 8.38e-54: 171: 38.42		KS6A5_HUMAN (28-293): 6.37e-20: 95.1: 28.57