Protein: CRP
C-reactive protein [Cleaved into: C-reactive protein(1-205)]

Gene: CRP
Organism: Homo sapiens
Interactions: 114
UniProt ID: P02741

Gene Ontology (top 5):
GO:0001849 - complement component C1q complex binding
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006953 - acute-phase response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

388476

CRP

2

8

Small-scale

0.815

High

388483

CFAH
Complement factor H

9

6

Small-scale

0.760

High

136766

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

3

3

High-throughput

0.662

High

183209

LAMA5
Laminin subunit alpha-5

3

8

High-throughput

0.662

High

335371

GDF11
Growth/differentiation factor 11

3

3

High-throughput

0.662

High

388481

LAMB1
Laminin subunit beta-1

3

5

High-throughput

0.662

High

388507

LAMB2
Laminin subunit beta-2

3

5

High-throughput

0.662

High

388546

FHR4
Complement factor H-related protein 4

2

6

Small-scale

0.653

High

388477

SAMP
Serum amyloid P-component

1

8

Small-scale

0.647

High

388490

CEBPB
CCAAT/enhancer-binding protein beta

3

4

Small-scale

0.640

High

388492

NFKB1
Nuclear factor NF-kappa-B p105 subunit

3

1

Small-scale

0.640

High

133157

QSOX1
Sulfhydryl oxidase 1

3

0

High-throughput

0.634

High

388502

TIMP3
Metalloproteinase inhibitor 3

3

0

High-throughput

0.634

High

388566

CEIP2
Cell surface hyaluronidase CEMIP2

3

0

High-throughput

0.634

High

388495

LAMA1
Laminin subunit alpha-1

2

5

High-throughput

0.628

High

388503

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

1

High-throughput

0.628

High

388522

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

2

1

High-throughput

0.628

High

388555

CNTP3
Contactin-associated protein-like 3

2

4

High-throughput

0.628

High

388496

PTX3
Pentraxin-related protein PTX3

1

8

Small-scale

0.618

High

388529

FCN2
Ficolin-2

2

5

Small-scale

0.611

High

212049

B4GT5
Beta-1,4-galactosyltransferase 5

3

3

High-throughput

0.604

High

388541

CHST3
Carbohydrate sulfotransferase 3

3

2

High-throughput

0.604

High

388559

CHSTC
Carbohydrate sulfotransferase 12

3

3

High-throughput

0.604

High

302232

STC2
Stanniocalcin-2

2

0

High-throughput

0.602

High

388510

RL23
Large ribosomal subunit protein uL14

2

0

High-throughput

0.602

High

388547

NXPE3
NXPE family member 3

2

0

High-throughput

0.602

High

251136

B4GT4
Beta-1,4-galactosyltransferase 4

2

3

High-throughput

0.601

High

388487

LAMC1
Laminin subunit gamma-1

2

5

High-throughput

0.601

High

251059

B4GT3
Beta-1,4-galactosyltransferase 3

2

3

High-throughput

0.574

High

388565

B4GT7
Beta-1,4-galactosyltransferase 7

2

3

High-throughput

0.574

High

388489

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

1

6

Small-scale

0.553

High

388499

FCG2C
Low affinity immunoglobulin gamma Fc region receptor II-c

1

6

Small-scale

0.553

High

388511

CNTP1
Contactin-associated protein 1

2

5

High-throughput

0.549

High

388544

CHSTE
Carbohydrate sulfotransferase 14

2

3

High-throughput

0.549

High

388557

CHST6
Carbohydrate sulfotransferase 6

2

2

High-throughput

0.549

High

388560

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

2

1

High-throughput

0.549

High

141975

FCN1
Ficolin-1

1

5

Small-scale

0.536

High

388538

CSPG4
Chondroitin sulfate proteoglycan 4

1

5

High-throughput

0.536

High

388486

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.515

High

183839

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

0

High-throughput

0.513

High

284017

CAH11
Carbonic anhydrase-related protein 11

1

0

High-throughput

0.513

High

388482

CO4A2

1

0

High-throughput

0.513

High

388527

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

0

High-throughput

0.513

High

388533

LRC24
Leucine-rich repeat-containing protein 24

1

0

High-throughput

0.513

High

388550

CNT3B
Contactin-associated protein-like 3B

2

4

High-throughput

0.504

High

388478

C1QA
Complement C1q subcomponent subunit A

1

5

Small-scale

0.501

High

388479

FINC
Fibronectin

1

3

Small-scale

0.501

High

388517

FHR3
Complement factor H-related protein 3

1

5

Small-scale

0.501

High

388534

COL12
Collectin-12

1

3

Small-scale

0.501

High

164720

HS3S1
Heparan sulfate glucosamine 3-O-sulfotransferase 1

1

1

High-throughput

0.489

High

388501

IDUA
Alpha-L-iduronidase

1

1

High-throughput

0.489

High

388506

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.489

High

388509

SIA8F
Alpha-2,8-sialyltransferase 8F

1

1

High-throughput

0.489

High

388513

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

High-throughput

0.489

High

388552

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

388498

MK01
Mitogen-activated protein kinase 1

1

3

High-throughput

0.481

High

388568

LAMC3
Laminin subunit gamma-3

1

5

High-throughput

0.481

High

388494

FCAR
Immunoglobulin alpha Fc receptor

1

3

Small-scale

0.479

High

388497

MK03
Mitogen-activated protein kinase 3

1

3

High-throughput

0.464

High

388480

IL6
Interleukin-6

1

0

Small-scale

0.458

High

388500

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

388520

SUH
Recombining binding protein suppressor of hairless

1

0

Small-scale

0.458

High

366453

UROK
Urokinase-type plasminogen activator

1

2

High-throughput

0.445

High

376659

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

3

High-throughput

0.445

High

388485

CO4A
Complement C4-A

1

1

High-throughput

0.445

High

388493

FBLN1
Fibulin-1

1

1

High-throughput

0.445

High

388521

MFGM
Lactadherin

1

3

High-throughput

0.445

High

388505

CEBPD
CCAAT/enhancer-binding protein delta

1

4

Small-scale

0.437

High

388514

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

1

Small-scale

0.437

High

388491

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.426

High

388523

SEPR
Prolyl endopeptidase FAP

1

0

High-throughput

0.426

High

388524

NOGG
Noggin

1

0

High-throughput

0.426

High

388532

INAVA
Innate immunity activator protein

1

0

High-throughput

0.426

High

388535

METRL
Meteorin-like protein

1

0

High-throughput

0.426

High

388537

PONL1
Podocan-like protein 1

1

0

High-throughput

0.426

High

388539

GLB1L
Beta-galactosidase-1-like protein

1

0

High-throughput

0.426

High

194667

FFAR2
Free fatty acid receptor 2

1

2

Small-scale

0.417

High

388508

GMFB
Glia maturation factor beta

1

1

High-throughput

0.407

High

388512

SRPX
Sushi repeat-containing protein SRPX

1

6

High-throughput

0.407

High

388556

CHST5
Carbohydrate sulfotransferase 5

1

2

High-throughput

0.407

High

388563

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

1

High-throughput

0.407

High

388564

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.407

High

388525

PTPRS
Receptor-type tyrosine-protein phosphatase S

3

0

High-throughput

0.345

High

388540

UBR3
E3 ubiquitin-protein ligase UBR3

3

0

High-throughput

0.345

High

239478

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

2

0

High-throughput

0.328

High

326228

PRS23
Serine protease 23

2

0

High-throughput

0.328

High

388488

SPTB1
Spectrin beta chain, erythrocytic

2

0

High-throughput

0.328

High

388530

EXT1
Exostosin-1

2

0

High-throughput

0.328

High

388558

DEFM
Peptide deformylase, mitochondrial

2

0

High-throughput

0.328

High

388567

RL26L
Ribosomal protein uL24-like

2

0

High-throughput

0.318

High

388528

PDIA5
Protein disulfide-isomerase A5

2

0

High-throughput

0.313

High

388526

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

0

High-throughput

0.300

High

388549

GMPPA
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha

1

0

High-throughput

0.299

High

388551

STRBP
Spermatid perinuclear RNA-binding protein

1

0

High-throughput

0.279

Low

388554

TMM59
Transmembrane protein 59

1

0

High-throughput

0.279

Low

388562

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

1

0

High-throughput

0.279

Low

388516

H11
Histone H1.1

1

0

Small-scale

0.261

Low

388531

H2A2C
Histone H2A type 2-C

1

0

Small-scale

0.261

Low

359561

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.251

Low

388504

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.251

Low

388519

UBE3A
Ubiquitin-protein ligase E3A

1

0

Small-scale

0.251

Low

388548

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.251

Low

388484

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

Small-scale

0.249

Low

388518

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

Small-scale

0.249

Low

225464

CYH3
Cytohesin-3

1

0

High-throughput

0.232

Low

338222

G6PE
GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase

1

0

High-throughput

0.232

Low

388515

B4GN1
Beta-1,4 N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.232

Low

388536

RWDD4
RWD domain-containing protein 4

1

0

High-throughput

0.232

Low

388542

P3H3
Prolyl 3-hydroxylase 3

1

0

High-throughput

0.232

Low

388543

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.232

Low

388545

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.232

Low

388553

MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

0

High-throughput

0.232

Low

388561

ADPRS
ADP-ribosylhydrolase ARH3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025