HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030425 - dendrite GO:0032930 - positive regulation of superoxide anion generation and 1 others more... GO:0044297 - cell body
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 758
+	Hs
		496793 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		444653 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		450973 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496575 GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496380 GNA11_HUMAN (1-354): 2.62e-162: 459: 50.42		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496266 GNAZ_HUMAN (1-354): 6.56e-160: 453: 66.38		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		325959 GNA14_HUMAN (3-354): 2.08e-158: 449: 49.86		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Mm
		444631 GNAI2_MOUSE (1-355): 1.99e-178: 500: 98.31		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Rn
		581959 GNAO_RAT (1-355): 7.36e-172: 483: 68.45		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94182 GNAO_RAT (1-355): 7.36e-172: 483: 68.45		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Mm
		70618 GNAI1_MOUSE (1-355): 8.33e-178: 498: 87.89		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		497017 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496792 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Mm
		497926 GNAQ_MOUSE (1-354): 4.5e-165: 466: 50.42		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Mm
		497925 GNA11_MOUSE (1-354): 3.82e-163: 461: 50.99		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Mm
		250846 GNAZ_MOUSE (1-354): 1.53e-160: 455: 65.82		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17