Protein: MLE
Dosage compensation regulator mle (EC 3.6.4.13) (Protein male-less) (Protein maleless) (Protein no action potential)

Gene: MLE
Organism: Drosophila melanogaster
Interactions: 49
UniProt ID: P24785

Gene Ontology (top 5):
GO:0000228 - nuclear chromosome
GO:0000785 - chromatin
GO:0000805 - X chromosome
GO:0001069 - regulatory region RNA binding
GO:0003678 - DNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666600

MLE
Dosage compensation regulator mle

2

13

Small-scale

0.757

High

666604

MSL1
Protein male-specific lethal-1

6

0

Small-scale

0.690

High

666605

MSL3
Protein male-specific lethal-3

5

0

Small-scale

0.672

High

356719

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

12

Small-scale

0.618

High

583626

TOP2
DNA topoisomerase 2

1

3

Small-scale

0.618

High

666603

MSL2
E3 ubiquitin-protein ligase msl-2

3

0

Small-scale

0.613

High

145739

MOF
Histone acetyltransferase MOF

2

1

Small-scale

0.584

High

55865

A1Z9K8
LD13733p

1

1

High-throughput

0.555

High

666607

Q0E8K8
FI21816p1

1

10

High-throughput

0.536

High

666614

Q8SYU5
RE33762p

1

10

High-throughput

0.489

High

666622

Q9VGU4
FI02822p

1

10

High-throughput

0.489

High

666624

Q9VK18
LD36945p

1

0

High-throughput

0.486

High

666609

Q2PDV9
Uncharacterized protein, isoform G

1

2

High-throughput

0.481

High

402257

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.479

High

666602

RB87F
Heterogeneous nuclear ribonucleoprotein 87F

1

12

Small-scale

0.479

High

666606

Q0E8J0
MOG interacting and ectopic P-granules protein 1

1

3

Small-scale

0.479

High

666617

FOXO
Forkhead box protein O

1

2

High-throughput

0.479

High

666621

Q9VCC9
LD23779p

1

8

High-throughput

0.479

High

666632

ENY2
Enhancer of yellow 2 transcription factor

1

1

Small-scale

0.479

High

583733

AMAL
Protein amalgam

1

2

High-throughput

0.464

High

120275

M9PD17
Gigas, isoform B

1

0

High-throughput

0.458

High

666601

PEP
Zinc finger protein on ecdysone puffs

1

0

Small-scale

0.458

High

666618

Q960V1
LD33361p

1

0

Small-scale

0.458

High

666625

Q9VPJ7
FI05267p

1

1

High-throughput

0.457

High

55289

PTCD3
Small ribosomal subunit protein mS39

1

2

High-throughput

0.445

High

666611

Q86BI3
Zinc-finger protein at 72D, isoform B

1

7

High-throughput

0.445

High

666612

Q8SXF0
Small ribosomal subunit protein uS9m

1

7

High-throughput

0.445

High

666613

Q8SYP9
Small ribosomal subunit protein uS5m

1

7

High-throughput

0.445

High

119559

M9PAY7
Pi3K21B, isoform C

1

5

High-throughput

0.437

High

666630

LSD2
Lipid storage droplets surface-binding protein 2

1

0

High-throughput

0.426

High

666619

FRIL
Ferritin light chain

1

2

High-throughput

0.407

High

666620

Q9VAY9
GH07821p

1

1

High-throughput

0.407

High

666623

Q9VIN9
Small ribosomal subunit protein mS40

1

2

High-throughput

0.407

High

666626

Q9VUX1
Small ribosomal subunit protein mS31

1

1

High-throughput

0.407

High

666627

Q9VV39
Mitochondrial ribosomal protein S34

1

1

High-throughput

0.407

High

666629

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.407

High

666631

RT25
Small ribosomal subunit protein mS25

1

1

High-throughput

0.407

High

666633

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.407

High

666634

Q9VZX6
LD06441p

1

1

High-throughput

0.407

High

666635

Q9W199
GEO07594p1

1

2

High-throughput

0.407

High

666636

Q9W253
Small ribosomal subunit protein mS29

1

1

High-throughput

0.407

High

666608

Q29QS8
IP11711p

1

0

High-throughput

0.265

Low

666610

Q7KTI0
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.265

Low

666628

CCD22
Coiled-coil domain-containing protein 22 homolog

1

0

High-throughput

0.265

Low

666615

Q8SZH8
LD13504p

1

0

High-throughput

0.238

Low

305784

O77477
LD24471p

1

0

High-throughput

0.232

Low

465870

CO4A1
Collagen alpha-1(IV) chain

1

0

High-throughput

0.232

Low

666616

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025